Human Sera
Cayman Chemical ElaIdIc AcId 100mg
A trans fatty acid; reduces arachidonic acid-induced HHT and HETE formation and increases arachidonic acid-induced synthesis of PGE2, PGF2α, PGD2, and TXB2 in isolated human platelets; induces apoptosis in HUVECs from 0.1-5 mmol/L; reduces palmitic acid-induced cardiac and hepatic autophagy in mice at 100 mg/kg
Cayman Chemical DabIgatrn etexIlate 50mg
A prodrug form of dabigatran; inhibits thrombin-induced platelet aggregation in isolated rabbit platelets (IC50 = 0.337 µM); inhibits thrombus formation in a rat model of venous thrombosis (ED50 = 7.8 µmol/kg)
Cayman Chemical ttramthyl NordIhydroguaIr 50mg
A derivative of nordihydroguaiaretic acid; inhibits Tat-regulated HIV promoter transactivation in COS-1 cells in a reporter assay (IC50 = 11 µM); inhibits replication of acyclovir-sensitive and -resistant strains of HSV-1 in Vero cells (IC50s = 5.6 and 8.9 µM, respectively); induces cell cycle arrest at the G1/G0 phase in A375 cells at 50 µM; inhibits tumor growth in an A375 mouse xenograft model at 250 mg/kg; inhibits tumor growth in a B16 murine melanoma model at 166 mg/kg
Cayman Chemical MolsIdomIn 100mg
Molsidomine is a NO-releasing prodrug. Liver esterases convert molsidomine to the active metabolite, SIN-1 (half-life in plasma is 1-2 hours), which then releases NO.
Cayman Chemical 7-ChlorokynurenIc AcId 50mg
A glycine-site selective NMDA receptor antagonist; selectively binds to the NMDA receptor glycine-binding site (IC50 = 0.56 µM) over the NMDA-, quisqualate-, and kainate-binding sites (IC50s = 169, 153, and >1,000 µM, respectively); induces antidepressant-like activity in a variety of behavioral tests in mice at 0.1 and 1 mg/kg
Cayman Chemical PyrIdoal IsonIcotInyl hyd 50mg
A lipophilic, nontoxic, iron-chelating agent that shows high iron chelation efficacy both in vitro in cell culture models and also in vivo in rats and mice
Cayman Chemical ElvItegravIr 50mg
A quinolone antibiotic that inhibits HIV-1 integrase (IC50 = 7.2 nM); has antiviral activity against laboratory strains and clinical isolates of HIV-1 in MAGI cells (EC50s = 0.1-1.26 nM) and HIV-2 in PBMCs (EC50s = 0.3-0.9)
Cayman Chemical ZIyuglycosIde II 50mg
A glycoside with diverse biological activities; cytotoxic to SMMC-7721, PC-9, HCT116, MCF-7, and MDA-MB-231 cancer cells at 30 and 90 UG/ml; increases the number of white blood cells in peripheral blood and the number of HSPCs in a mouse model of cyclophosphamide-induced leukopenia at 6, 12, and 18 mg/kg; reduces small intestinal epithelial cell apoptosis and IL-1β, IL-6, and TNF-α levels, as well as improves diarrhea symptoms in a mouse model of rotavirus-induced diarrhea
Cayman Chemical ThymohydroquInon 50mg
A quinone with diverse biological activities; scavenges DPPH free radicals in a cell-free assay (IC50 = 2.4 μg/ml); has a Trolox equivalent value of 2.6 in an ORAC assay at 1.6-6.4 μg/ml; inhibits growth of A2780, OVCAR-8, and CIS-A2780 ovarian cancer cells (IC50s = 3.1, 8.9, and 9.8 μM, respectively) as well as immortalized human ovarian epithelial cells (IC50 = 14 μM); active against P. falciparum in vitro (IC50 = 15.9 μM)
Cayman Chemical SalmeterolxInafoate 50mg
A long-acting β2-AR agonist (EC50s = 0.79, 63.1, and 9.4 nM for β2-, β1-, and β3-ARs, respectively); inhibits electrically-stimulated contraction of isolated guinea pig trachea strips (EC50 = 2.51 nM); inhibits histamine-induced bronchoconstriction in guinea pigs via aerosol administration at 0.12-12 mM
Cayman Chemical FIdaxomycIn 50mg
A natural macrocyclic antibiotic that inhibits RNA polymerase with selectivity for Gram-positive bacteria over Gram-negative bacteria (IC50s = 0.4 and 6 μM, respectively); has potent antibacterial activity against most Gram-positive bacteria and effectively targets the Gram-positive C. difficile (MIC = 12 ng/ml)
Cayman Chemical namInhydrochlorIde 50mg
A natural degradation product of neomycin; a common core molecule used in the synthesis of aminoglycoside antibiotics
Cayman Chemical TrIamcInolon 100mg
A synthetic glucocorticoid; increases expression of the calcitonin receptor in in murine osteoclast-like cells at 1 μM; reduces heat hyperalgesia and mechano-allodynia and decreases the number of TNF-α-positive mast cells in injured sciatic nerve in a rat model of chronic constriction injury-induced neuropathic pain at 3 mg/kg, s.c.; reduces levels of the glycosaminoglycans hyaluronic acid and chondroitin-4-sulfate in human keloid implants in athymic nude mice
Sigma Aldrich Fine Chemicals Biosciences Human Serum Heat Inactivated (from male AB clotted whole blood), USA origin, sterile-filtered, MFCD00165829
Human Serum Heat Inactivated (from male AB clotted whole blood), USA origin, sterile-filtered
Sino Biological Recombinant Human C5AR1/C5R1/CD88 Protein (Nanodisc, thermostabilizing mutations, Flag-Strep & His tag)
A DNA sequence encoding the Human C5AR1 (P21730)(Met1-Lys333) was expressed, with a Flag tag followed by a Strep Tag at the N-terminus, a polyhistidine tag at the C-terminus. Within the expressed regions, there are several proprietary thermostabilizing mutations. This protein was prepared using our Nanodisc platform. Nanodisc is a versatile tool for studying membrane proteins. Using styrene-maleic acid (SMA) copolymer, membrane proteins can be extracted directly from prokaryotic and eukaryotic expression systems in the absence of detergents to preserve the protein structure and function better. Compared to membrane scaffold proteins (MSPs) nanodiscs, SMA nanodiscs also have the advantage of preserving proteins' nature by maintaining native lipids surrounded without introducing any heterologous proteins, which allows studies of protein structure and functions in a native-like environment.