Human Sera
Cayman Chemical QuercetIn 3ODGlucose7O 50mg
A flavonoid glycoside with lipid-lowering activity; reduces sodium oleate-induced increases in triglyceride levels in HepG2 cells at 30 µM
Cayman Chemical SuramInsodIum salt 100mg
A polysulfonated naphthylurea with antiviral, antiparasitic, and anticancer activities; is negatively charged at physiological pH therefore exhibiting polypharmacology; reduces Zika virus infectivity in Vero cells (IC50 = ~2.5-5 UG/ml); induces cell cycle arrest at the G2/M phase and apoptosis in L. donovani promastigotes in vitro and reduces hepatic parasitic burden in a mouse model of L. donovani-induced visceral leishmaniasis; reduces tumor volume in PDX mouse models of malignant mesothelioma at 60 mg/kg
Cayman Chemical 3- 4-PyrIdylIndole 50mg
A ROCK1 inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay; also inhibits ROCK2 and PRK2 with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency
Cayman Chemical CID-2818500 50mg
An inhibitor of PRMT1 (IC50 = 11 μM in a histone H4 methylation assay); inhibits histone H4 methylation by PRMT8, but not histone H3.1 methylation by CARM1 or Set7/9, at 10 and 100 μM
Cayman Chemical 6 2 4-TrImethoxyflavon 50mg
A flavonoid; inhibits benzo[a]pyrene-induced AhR-dependent transcription in a reporter assay at 2 and 10 µM; decreases LPS-induced production of TNF-α in THP-1 cells (IC50 = 47.7 UG/ml); inhibits cell migration and invasion of HN-30 HNSCC cells at 10 µM
Cayman Chemical LIpId HTO12 50mg
An ionizable cationic lipid (pKa = 6.432); has been used in combination with other lipids in the formation of LNPs for the delivery of mRNA in vitro and in vivo; LNPs containing lipid HTO12 and encapsulating adenine base editor mRNA targeting Pcsk9 reduce hepatic Pcsk9 levels in mice at a reduced ionizable lipid/total lipids-to-mRNA ratio than LNPs containing SM-102
Cayman Chemical GaboxadolhydrochlorIde 50mg
A GABAA receptor agonist whose potency varies depending on the receptor subunit composition (partial agonist at α1β2γ2 (ED50 = 143 µM), full agonist at α5 (ED50 = 28-129 µM), and super agonist at α4β3δ (ED50 = 6 µM)); acts as an antagonist at ρ1 GABAC receptors (IC50 = 25 µM).
Cayman Chemical DIclofensInhydrochlorIde 50mg
A potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively; intended for research and forensic applications
Cayman Chemical TolterodIntartrate 50mg
A muscarinic acetylcholine receptor antagonist (Kis = 1.4, 2.7, 3.6, 3.1, and 2.2 nM for M1-5 receptors, respectively); reduces carbachol-induced intracellular calcium mobilization in bladder smooth muscle cells and submandibular gland cells isolated from cynomolgus monkeys (Kis = 3.16 and 2 nM, respectively); inhibits volume-induced bladder contractions and oxotremorine-induced salivation in rats (ID50s = 0.025 and 0.12 mg/kg, respectively)
Cayman Chemical Paclobutrazol 100mg
A triazole-containing plant growth retardant that is known to inhibit the biosynthesis of gibberellins
Cayman Chemical EnzalutamIde 50mg
A non-steroidal androgen receptor antagonist (IC50 = 36 nM); reduces the efficiency of nuclear translocation of the androgen receptor and impairs both its binding to DNA and the recruitment of coactivators
Cayman Chemical PF-562271besylate 50mg
An ATP-competitive, reversible inhibitor of FAK (IC50 = 1.5 nM) and PYK2 (IC50 = 14 nM); inhibits FAK phosphorylation (EC50 = 93 ng/ml) in glioblastoma-bearing mice and has been shown to regress tumors in multiple xenograft models
Cayman Chemical UDPsodIum salt hydrate 100mg
The diphosphate of uridine; a specific agonist of the P2Y purinoceptor P2Y6 (EC50 = 13 nM for human P2Y6), stimulating the production of inflammatory mediators, phagocytosis, and vasoconstriction; an antagonist of P2Y14
Cayman Chemical MItoxntronhydrochlorIde 50mg
An inhibitor of DNA topoisomerase IIα and HIV-1 integrase (IC50s = 5.3 and 3.8 μM, respectively); intercalates DNA in a cell-free assay at 2 µM; inhibits DNA synthesis and induces DNA-protein crosslinks in vitro; inhibits the growth of K562 and K562-derived etoposide-resistant K/VP.5 cells (IC50s = 0.42 and 1.68 µM, respectively); inhibits HIV-1 integrase (IC50 = 3.8 μM); inhibits the membrane fusion of a mixed population of HEK293T cells expressing either ACE2 or the extracellular domain SARS-CoV-2 spike glycoprotein; inhibits the entry of SARS-CoV-2 into Vero E6 cells at 0.2 µM