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There are five immunoglobulin classes in humans. Out of these immunoglobulin M (IgM) is a high molecular weight protein that has five or six subunits. IgM monomers are made of two heavy chains and two light chains connected by a disulfide bond. Human serum shows low concentration of IgM monomers. It has a high carbohydrate content of about 12%. It is the first immunoglobulin produced by neonates.IgM antibodies are present as pentamers in the serum and are produced in response to antigens.IgM from human serum is purified from normal human serum by precipitation and gel filtration techniques. The immunoglobulin is determined to be atleast 95% pure by HPLC procedures.
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An AChE modulator; induces inhibition and activation of bovine erythrocyte AChE in the presence and absence of ACh, respectively, at 3 mM; induces reactivation of tabun-inhibited AChE in rat blood and diaphragm and reduces tabun-induced lethality in mice at 10.5 mg/kg; intranasal administration reduces seizure duration and severity and prevents mortality in a rat model of paraoxon-induced organophosphate poisoning
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This reagent is a 6% recombinant HSA (Human Serum Albumin) in PBS SOLUTIONon pH 7.4 that can be used as a blank or matrix/diluent for proteinaceous analytes in LC-MS/MS calibrators controls or samples.The 6% protein content design is meant to mimic endogenous protein concentration in human serum samples.Beneficially as the HSA source is recombinant the matrix should not contain any measurable contaminants typically found in even stripped serum.
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Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.
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A protein-modifying agent; introduces sulfhydryl groups to proteins; used in conjunction with the protein cross-linking reagent SMCC in the conjugation of proteins with IgG antibodies for use in ELISAs
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A metabolite of trans-cinnamic acid; urinary levels are decreased in a mouse model of piperacillin- and tazobactam-induced gut microbiota colonization resistance; serum levels are increased in patients with CKD
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A MEK inhibitor (IC50 = 5.73 nM) and an active metabolite of CI-1040; reduces viral titers in A549 and MDCK cells infected with influenza A (EC50s = 6.356 and 4.498 µM, respectively); increases survival in H1N1pdm09 influenza A-infected mice at 50 mg/kg per day
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A colorimetric substrate for trypsin and papain; enzymatic cleavage releases pNA, which can be quantified by colorimetric detection at 405 nm as a measure of trypsin or papain activity
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