Guinea Pig Whole Blood
Cayman Chemical LAzetIdIn2carboxylIc ACD 250mg
A chiral building block has been used in the synthesis of a chiral synthetic antibiotic intermediate as well as in the stereoselective synthesis of NK receptor antagonists
Cayman Chemical DotrIacontnoIc ACD methyl50mg
A muscarinic receptor antagonist (Kis 1.62 27.5 and 2.63 nM for M1 M2 and M3 receptors respectively) inhibits carbachol-induced contraction of isolated human iris sphincter circular ciliary muscle and longitudinal ciliary muscle (Kbs 7.9 15.8 and 12.5 nM respectively)
Cayman Chemical DotrIacontnoIc ACD methyl10mg
An ectoparasiticide and antipruritic agent blocks mouse TRPV4 channel expressed in HEK293 cells in a calcium-dependent manner (IC50s 223.5 and 15.5 M in buffer containing 0 and 2 mM calcium respectively) inhibits scratching behavior in mice induced by the TRPV4 agonist GSK1016790A topical application inhibits scratching behavior in mice induced by histamine serotonin and the PAR2 agonist SLIGRL-NH2 (0.025 g of a 10 ointment)
Cayman Chemical AM694 NpentnoIc ACD metabo
A fluorescent cationic dye ex/em spectra 502/525 460/650 and 475/590 nm when bound to dsDNA bound to ssDNA or RNA and under acidic conditions respectively ratio of emission at 590 to emission at 525 nm can be used to quantify the increase in acidic vesicular organelles observed during cellular autophagy
Cayman Chemical LIthocholIc ACD MaxSpec Sta
Immunogen Synthetic peptide from the N-terminal region of the a3 subunit of the rat GABAA receptor Host Rabbit Species Reactivity ( ) Mouse Rat Applications IHC WB MW 51 kDa
Cayman Chemical GlycochenodeoxycholIc ACD
Features a biotin group and propanoic acid separated by a disulfide linkage allows biotinylation of targets through either a chemical or enzymatic acylation reaction disulfide bond permits removal of the biotin group with reducing agents
Cayman Chemical JWH 203 NpentnoIc ACD meta
A non-protein amino acid that chelates iron and copper inhibits certain enzymes that contain iron or copper including arginase (IC50 3.7 UM)
Cayman Chemical DocosatrIenoIc ACD methyl5mg
An orally bioavailable SARM that binds to the androgen receptor with a Ki value of 7 nM stimulates muscle weight increase without affecting prostate or seminal vesicle in castrated male rats
Cayman Chemical DocosatrIenoIc ACD methyl10mg
A central second messenger in cell signaling propagating signals from receptors to downstream pathways generated from ATP by several adenylate cyclase enzymes which are modulated by G protein-coupled receptors
Cayman Chemical 11 ZEIcosenoIc ACD methyl
A cyclic thiopeptide antibiotic first isolated from S bernensis inhibits protein biosynthesis in Gram positive bacteria through binding with ribosomal subunits induces the transcriptional activator TipA in Streptomyces
Cayman Chemical DocosapentaenoIc ACD ethyl5mg
A selective short-acting adenosine A2A receptor agonist (Ki 1 1 nM for pig striatum A2A receptor) used to induce hyperemia particularly in the context of myocardial perfusion imaging
Cayman Chemical ArachIdonIc ACD OxylIpIn Max
An HMG-CoA reductase inhibitor (IC50 5 nM) inhibits cholesterol synthesis in isolated rat hepatocytes (IC50 0 16 nM) reduces plasma total cholesterol triglyceride LDL-C and oxidized LDL-C levels in Ldlr-/- mice fed a high-fat diet at 10 mg/kg decreases the area of aortic atherosclerotic lesions in the same model
Cayman Chemical TaurochenodeoxycholIc ACD
A cell permeable inhibitor that blocks the binding of BH3 peptides to Bcl-xL inducing apoptosis inhibits interactions of BH3 domain-containing proteins with Bcl-xL Bcl-2 and Bcl-W inducing apoptosis in Bcl-2 or Bcl-W expressing cells with Ki values of 43 4 and 124 UM respectively
Cayman Chemical NonadecnoIc ACD methyl Ste
A potent activator of PKA (Ki 30 nM) that is selective for PKA over PKG (Ki 10 UM) resistant to degradation by cyclic nucleotide phosphodiesterases displays good cell permeability and prevents the aggregation of platelets stimulated with thrombin