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Matched antibody pairs are sets of antibodies that are known to be capable of detecting different epitopes on the same protein antigen; they can be used together for the capture and detection of a single antigen in an immunoassay.
CD70 also named CD27 ligand (CD27L) is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7 CD70 is a cytokine that binds to CD27 Plays a role in T-cell activation Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells
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CLEC2C (CD69) is a membrane-bound type II C-lectin receptor and acts as a costimulatory molecule for T cell activation and proliferation It is involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes natural killer (NK) cells and platelets CLEC2C is a disulfide-linked homodimer protein with two differentially glycosylated subunits
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The properties of retinol binding protein is the transport carrier of vitamin A in the plasma Human-retinol binding protein is a single-chain polypeptide with a molecular weight of approximately 21000 and one binding site for retinol and other forms of vitamin A In addition compounds related to retinol such as retinal retinoic acid retinyl esters and geometric isomers of retinol and of retinal were evaluated for their ability to bind to this protein In plasma RBP4-retinol forms a complex with transthyretin (TTR) also known as thyroxine-binding protein and prealbumin Defects in RBP4 cause retinol-binding protein deficiency which affects night vision
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The properties of retinol binding protein is the transport carrier of vitamin A in the plasma Human-retinol binding protein is a single-chain polypeptide with a molecular weight of approximately 21000 and one binding site for retinol and other forms of vitamin A In addition compounds related to retinol such as retinal retinoic acid retinyl esters and geometric isomers of retinol and of retinal were evaluated for their ability to bind to this protein In plasma RBP4-retinol forms a complex with transthyretin (TTR) also known as thyroxine-binding protein and prealbumin Defects in RBP4 cause retinol-binding protein deficiency which affects night vision
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Decay Accelerating Factor (or CD55) is a major regulator of the alternative and classical pathways of complement activation and is expressed on all serum-exposed cells It is commonly hijacked by invading pathogens including many enteroviruses and uropathogenic Escherichia coli to promote cellular attachment prior to infection
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CD79B (also known as B29 Ig beta and B cell antigen receptor complex-associated protein beta-chain) is a 36-40 kDa member of the Ig-Superfamily It is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex trafficking to late endosomes and antigen presentation Enhances phosphorylation of CD79A possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation
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Decay Accelerating Factor (or CD55) is a major regulator of the alternative and classical pathways of complement activation and is expressed on all serum-exposed cells It is commonly hijacked by invading pathogens including many enteroviruses and uropathogenic Escherichia coli to promote cellular attachment prior to infection
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The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells and recent studies suggest both play important inhibitory roles in immune function CD96 has been shown to modulate immune cell activity in mice with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor CD226 offers unique strategies for immuno-oncology drug development
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Mesothelin also known as MSLN is a 40 kDa protein that is expressed in mesothelial cells It has been reported that this protein is over expressed in several human tumors including mesothelioma ovarian cancer pancreatic adenocarcinoma lung adenocarcinoma and cholangiocarcinoma Mesothelin can bind MUC16 (also known as CA125) indicating that the interaction of mesothelin and MUC16 may contribute to the implantation and peritoneal spread of tumors by cell adhesion Since mesothelin is overexpressed in several cancers and is immunogenic the protein could be exploited as tumor marker or as the antigenic target of a therapeutic cancer vaccine
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Decay Accelerating Factor (or CD55) is a major regulator of the alternative and classical pathways of complement activation and is expressed on all serum-exposed cells It is commonly hijacked by invading pathogens including many enteroviruses and uropathogenic Escherichia coli to promote cellular attachment prior to infection
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This kit detects SERPINA12 (vaspin) in rat samples including serum plasma and tissue homogenates using a quantitative sandwich ELISA method It offers a detection range of 31 25 pg/mL to 2000 pg/mL with a sensitivity limit of 7 8 pg/mL providing precise measurement of visceral adipose-specific serine protease inhibitor levels The assay requires 50-100 L of sample per test and can be completed within 1-5 hours with absorbance readings taken at 450 nm Designed for research applications this reliable kit enables the study of metabolic regulation and adipose tissue function supporting investigations in obesity insulin resistance and related metabolic disorders through accurate quantification of SERPINA12 protein concentrations
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This ELISA kit is designed for the quantitative detection of Human Pancreatic Secretory Trypsin Inhibitor (SPINK1) in serum plasma and tissue homogenates using a sandwich assay format It offers a broad detection range from 78 pg/ml to 5000 pg/ml with a sensitivity limit of 19 5 pg/ml ensuring precise measurement across various sample concentrations The assay requires a short incubation period of 1-5 hours and utilizes a sample volume of 50-100 l per test Optical density is measured at 450 nm for result interpretation providing reliable and reproducible data for research applications requiring SPINK1 level analysis in biological samples
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