Rabbit Secondary Antibodies
ABclonal Technology Decorin Rabbit mAb
This gene encodes a member of the small leucine-rich proteoglycan family of proteins Alternative splicing results in multiple transcript variants at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein This protein plays a role in collagen fibril assembly Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis This gene and the related gene biglycan are thought to be the result of a gene duplication Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients
ABclonal Technology MTAP Rabbit mAb
This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage pathway of both adenine and methionine The encoded enzyme is deficient in many cancers Multiple alternatively spliced transcript variants have been described for this gene
ABclonal Technology APC Rabbit anti-Mouse IgG2b
Enables antigen binding activity Acts upstream of or within phagocytosis positive regulation of immune response and positive regulation of phagocytosis Located in extracellular space Part of immunoglobulin complex circulating Orthologous to several human genes including IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)) IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker)) and IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker))
Cayman Chemical CD5NTerm RabbIt Monclona 100uL
An inhibitor of B-RAF and C-RAF (IC50s 41 7 and 2 nM for wild-type B-RAF B-RAFV600E and wild-type C-RAF respectively) cytotoxic to B-RAFV600E-expressing A375 and SK-MEL-28 melanoma cells (IC50s 57 and 69 nM respectively) as well as COLO 205 and HCT116 colon and B-CPAP and CAL-62 thyroid cancer cells (IC50s 116 65 43 and 479 nM respectively) reduces tumor growth in A375 SK-MEL-28 SK-MEL-2 and SK-MEL-30 mouse xenograft models
Cayman Chemical GAPDHCTerm RabbIt Monclo 100uL
A cytosine derivative originally found to be an inhibitor of TET1 and TET2 (IC50s 33 and 73 UM respectively in cell-free assays) however it was found that the TET inhibitory activity was due to residual copper in the preparation copper-containing Bobcat 339 reduces DNA 5-hmC levels in HT22 hippocampal neurons at 10 UM but copper-free preparations do not reduce DNA 5-hmC levels in Hep3B cells at 50 UM
Cayman Chemical Anti-Histone H3 pan Rabbit Mo
Immunogen: Peptide corresponding to the C-terminus of human histone H3 • Host: Rabbit • Species Reactivity: Species independent • Cross Reactivity: (+) All histone H3 proteins independent of post-translational modifications (-) H2A, H2B, H4 • Applications: ELISA, ICC, multiplex-based assays, WB
Cayman Chemical CD5CTerm RabbIt Monclona 100uL
An inhibitor of SIK2 (IC50 50s 21.63 and 6.63 nM respectively) inhibits TNF-a secretion in RAW 264.7 cells (IC50 ~2.5 UM) and reduces phosphorylation of CRTC3 and HDAC4 in macrophages at 3 UM inhibits growth of 10 ovarian cancer cell lines (IC50s 0.8-2.6 UM) and increases sensitivity of eight of them to paclitaxel halts the cell cycle at the G2/M phase and induces apoptosis and tetraploidy in SKOV3 cells at 1 UM has an additive effect on reducing tumor growth when used in combination with paclitaxel in an ovarian cancer mouse xenograft model at 60 mg/kg per day
Cayman Chemical IgG2humn RabbIt Monclona 100ug
Immunogen: Human IgG2 • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) IgG2 Heavy Chain; (-) Human IgA, IgD, IgE, IgG1, IgG3, IgG4, IgM; (-) Cynomolgus monkey, goat, mouse, rat, rhesus monkey IgG • Application: ELISA
Cayman Chemical sPLA2Type IB RabbIt Moncl 1mL
Immunogen: Recombinant mouse sPLA2 (Type IB) • Host: Rabbit • Species Reactivity: (+) Mouse • Cross Reactivity: (+) sPLA2 (Type IB) • Applications: ELISA
ABclonal Technology TRAF4 Rabbit mAb
This gene encodes a member of the TNF receptor associated factor (TRAF) family TRAF proteins are associated with and mediate signal transduction from members of the TNF receptor superfamily The encoded protein has been shown to interact with neurotrophin receptor p75 (NTR NTSR1) and negatively regulate NTR induced cell death and NF-kappa B activation This protein has been found to bind to p47phox a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase This protein thus is thought to be involved in the oxidative activation of MAPK8 JNK Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined
Cayman Chemical Grnzyme BCTerm RabbIt Mo 100uL
An androgenically inactive metabolite of testosterone and androstenedione potentiates GABA-induced chloride currents in HEK293 cells expressing rat a1B2Y2L subunit-containing GABAA receptors at 10 UM protective against seizures induced by 6 Hz electroshock or PTZ (ED50s 76 9 and 139 mg/kg respectively) increases body temperature in rhesus macaques
ABclonal Technology APC Rabbit anti-Mouse IL-13
Predicted to enable interleukin-13 receptor binding activity Involved in positive regulation of cold-induced thermogenesis and positive regulation of macrophage activation Acts upstream of or within cellular response to cytokine stimulus inflammatory response and positive regulation of immune effector process Located in cytoplasm external side of plasma membrane and extracellular space Is expressed in gut liver male reproductive gland or organ and thymus Used to study atopic dermatitis Human ortholog(s) of this gene implicated in several diseases including allergic disease (multiple) autoimmune disease (multiple) diffuse scleroderma lung disease (multiple) and nose disease (multiple) Orthologous to human IL13 (interleukin 13)
Cayman Chemical CD1n-Term RabbIt Monclon 100uL
A CaMKK inhibitor (IC50s 120 and 40 ng/ml for CaMKKa and CaMKKB respectively) selective for CaMKKs over CaMKI CaMKII CaMKIV MLCK PKC PKA and p42 MAPK (IC50s ≥ 10000 ng/ml for all) inhibits phosphorylation of CaMKI and AMPK in chicken sperm in the presence of extracellular calcium as well as reduces chicken sperm motility decreases Npy and Agrp expression and cumulative food intake in mice at 20 M 0.5 L/hour i.c.v. increases cortical striatal and total infarct volume in a mouse model of MCAO-induced focal transient cerebral ischemia at 3 g/animal i.c.v.
Cayman Chemical TNFRSF8CD30C-Term RabbIt 100uL
A BMI1 inhibitor inhibits proliferation of OVCAR-4 and OV-90 cells (IC50s 0 1 UM for both) induces BMI1 degradation in and apoptosis of the same cells reduces microtubule polymerization and induces cell cycle arrest at the G2/M phase in MDS-L cells at 3 and 0 03 UM respectively reduces tumor growth in a OV-90 orthotopic mouse model of ovarian cancer at 15 mg/kg biweekly
ABclonal Technology RING1B/RNF2 Rabbit mAb
Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation The protein encoded by this gene is one of the PcG proteins It has been shown to interact with and suppress the activity of transcription factor CP2 (TFCP2 CP2) Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis as well as in cell proliferation in early development This protein was also found to interact with huntingtin interacting protein 2 (HIP2) an ubiquitin-conjugating enzyme and possess ubiquitin ligase activity