Rabbit Secondary Antibodies
Jackson Immuno Research Labs Alkaline Phosphatase-AffiniPure Rabbit Anti-Human IgG F(ab')2 Fragment Specific
Alkaline Phosphatase-AffiniPure Rabbit Anti-Human IgG F(ab')2 Fragment Specific
ABclonal Technology 450 Rabbit anti-Human Ki67
Enables protein C-terminus binding activity Involved in regulation of chromosome segregation and regulation of mitotic nuclear division Located in chromosome nuclear body and nucleolus Colocalizes with condensed chromosome Implicated in Crohn s disease breast cancer human immunodeficiency virus infectious disease and pancreatic cancer Biomarker of several diseases including Barrett s esophagus autoimmune disease of musculoskeletal system (multiple) endocrine gland cancer (multiple) gastrointestinal system cancer (multiple) and interstitial cystitis
ABclonal Technology 594 Rabbit anti-Human CD172b
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family and also belongs to the immunoglobulin superfamily SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes This protein was found to interact with TYROBP DAP12 a protein bearing immunoreceptor tyrosine-based activation motifs This protein was also reported to participate in the recruitment of tyrosine kinase SYK Multiple transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 647 Rabbit anti-Human BCL6
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain This protein acts as a sequence-specific repressor of transcription and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL) and may be involved in the pathogenesis of DLCL Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene
ABclonal Technology 594 Rabbit anti-Human TROP-2
This intronless gene encodes a carcinoma-associated antigen This antigen is a cell surface receptor that transduces calcium signals Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy
ABclonal Technology PE Rabbit anti-Human TMPRSS2
This gene encodes a protein that belongs to the serine protease family The encoded protein contains a type II transmembrane domain a receptor class A domain a scavenger receptor cysteine-rich domain and a protease domain Serine proteases are known to be involved in many physiological and pathological processes This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E MERS-CoV SARS-CoV and SARS-CoV-2 (COVID-19 virus) Alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 610 Rabbit anti-Human BCL6
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain This protein acts as a sequence-specific repressor of transcription and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL) and may be involved in the pathogenesis of DLCL Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene
ABclonal Technology 488 Rabbit anti-Human ERG
This gene encodes a member of the ETS family of transcription factors which regulate embryonic development cell proliferation differentiation angiogenesis inflammation and apoptosis The protein contains an ETS DNA-binding domain and a PNT domain involved in self-association of oncoproteins It is primarily expressed in the nucleus and plays a role in platelet adhesion to the subendothelium vascular remodeling hematopoiesis and megakaryocyte differentiation This gene is involved in chromosomal translocations leading to fusion proteins like TMPSSR2-ERG in prostate cancer EWS-ERG in Ewing s sarcoma and FUS-ERG in acute myeloid leukemia Over two dozen transcript variants have been reported though the full-length forms of many are undetermined
ABclonal Technology 488 Rabbit anti-Human CD79a
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component surface immunoglobulin (Ig) Surface Ig non-covalently associates with two other proteins Ig-alpha and Ig-beta which are necessary for expression and function of the B-cell antigen receptor This gene encodes the Ig-alpha protein of the B-cell antigen component Alternatively spliced transcript variants encoding different isoforms have been described
ABclonal Technology 488 Rabbit anti-Human GP6/GPVI
This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11) Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene
ABclonal Technology 450 Rabbit anti-Human CD89
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils monocytes macrophages and eosinophils where it mediates immunologic responses to pathogens It interacts with IgA-opsonized targets and triggers several immunologic defense processes including phagocytosis antibody-dependent cell-mediated cytotoxicity and stimulation of the release of inflammatory mediators Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene
ABclonal Technology 488 Rabbit anti-Human P4HB
This gene encodes the beta subunit of prolyl 4-hydroxylase a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family When present as a tetramer consisting of two alpha and two beta subunits this enzyme is involved in hydroxylation of prolyl residues in preprocollagen This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation breakage and rearrangement of disulfide bonds Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner its ability to bind thyroid hormone its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide and its function as a subunit of the microsomal triglyceride transfer protein complex
ABclonal Technology 450 Rabbit anti-Human CD94
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation Several genes of the C-type lectin superfamily including members of the NKG2 family are expressed by NK cells and may be involved in the regulation of NK cell function KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus Several transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 700 Rabbit anti-Human CD142
This gene encodes coagulation factor III a cell surface glycoprotein that initiates blood coagulation by acting as a high-affinity receptor for factor VII The resulting complex triggers protease cascades via limited proteolysis Unlike other circulating cofactors factor III is fully active when expressed on cell surfaces such as monocytes It has three domains extracellular transmembrane and cytoplasmic Its expression is induced by procoagulatory and proinflammatory stimuli and is implicated in HIV-associated coagulopathy and COVID-19 severity Notably no congenital deficiency has been identified Multiple transcript variants arise from alternative splicing