Apoptosis Reagents and Kits
Vector Biolabs CASP8 and FADD-like apoptosis regulator Adenovirus (Ad-FLIP)
Ready to use in vivo grade AAV and Adenovirus Ready to use in vivo grade AAV and Adenovirus pre synthesized DNA vector High titer viral vectors 1/EA
Selleck Chemical LLC A-1155463 5mg 1235034-55-5
A-1155463, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM). *For Research & Development use only. Product is not intended for drug, household, or human consumption.
AdipoGen RBN-2397
Chemical. CAS 2381037-82-5. Formula C20H23F6N7O3. MW 523.4. RBN-2397 is a potent NAD competitive small molecule inhibitor of PARP-7. RBN-2397 selectively inhibits PARP-7 and demonstrates >50-fold selectivity for inhibition of PARP-7 over all PARP family members as measured by biochemical assays. RBN-2397 inhibits PARP-7-dependent MARylation IC50 = 2nM in cell biochemical assay and inhibits cells proliferation in NCI-H1373 lung cancer cells IC50 = 20nM. By selectively inhibiting PARP-7 in tumor cells, RBN-2397 has been shown to directly inhibit cellular proliferation and restore Type I interferon signaling to stimulate an innate and adaptive antitumor immune response. Targeting cytosolic nucleic acid sensing pathways and the Type I interferon IFN response is an emerging therapeutic strategy being explored in oncology. The PARP family consists of seventeen enzymes that regulate fundamental biological processes including response to cellular stress.
AdipoGen SP600125
Chemical. CAS 129-56-6. Formula C14H8N2O. MW 220.2. SP600125 is an orally active, reversible and ATP-competitive broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 IC50 = 40nM, 40nM and 90nM, respectively. In Jurkat T cells, SP600125 suppressed the phosphorylation of c-Jun with IC50 of 5-10 µM. It has 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB and PKCalpha, and 100-fold selectivity against ERK2, p38, Chk1, EGFR. SP600125 is also a broad-spectrum inhibitor of serine/threonine kinases including hydrocarbon receptor AhR, Mps1, Aurora kinase A, FLT3 and TRKA. SP600125 inhibits cell cycle, autophagy and ferroptosis and activates apoptosis. It shows anti-inflammatory activity by inhibiting the expression of inflammatory genes such as COX-2, IL-2 IFN-gamma and TNF-alpha and has antiviral and neuroprotective properties.
Abcam DNase I Assay Kit (Fluorometric)
DNase I Assay Kit (Fluorometric)
The product is subject to the following: Abcam Restricted Use Statement
Enzo Life Sciences GFP-CERTIFIED Apoptosis/Necrosis detection kit (1x25assays)
Multiplex assay that distinguishes between healthy, early apoptotic, late apoptotic and necrotic cells, compatible with GFP and other green fluorescent probes. Applications: Flow Cytometry. Fluorescence microscopy. Fluorescent detection. Contents: Apoptosis Detection Reagent (Annexin V-EnzoGold). Necrosis Detection Reagent. Apoptosis Inducer (Staurosporine). Binding Buffer (10X)
Bioss Caspase-6 - C-terminal region
Caspase-6 (C-terminal region) Primary Antibody Unconjugated Host Species Mouse Target Species Human Clonality Monoclonal Applications WB M378Concentration Size 100 ul Storage Buffer PBS 1 mg/ml BSA 0 05% NaN3 and 50% glycerol
Enzo Life Sciences Z-VAD-FMK (5 mg) CAS: 220644-02-0
Pan-Caspase Inhibitor. Z-VAD-FMK acts as an effective irreversible caspase inhibitor with no cytotoxic effects and, therefore, is a useful tool for studying caspase activity. Irreversible, cell permeable broad-spectrum caspase inhibitor. Alternative Name: Caspase family inhibitor (fluoromethylketone), Z-Val-Ala-DL-Asp-FMK. Formula: C21H28FN3O7. MW: 453.5. CAS: 220644-02-0. Purity: ≥98% (HPLC). Sequence Z-Val-Ala-Asp-fluoromethylketone. Appearance: Solid. Solubility: Soluble in DMSO or acetonitrile (10mg/ml). Long Term Storage: -20°C. Use/Stability: Keep sealed after removing from the freezer until its temperature equilibrates with room temperature. Dissolve only the amount needed at one time because of the possibility of decomposition in solution. Handling: After reconstitution, prepare aliquots and store at -20°C.
Sartorius Incucyte Caspase-3/7 Dye for Apoptosis (RED)
Caspase 3/7 Red reagent for apoptosis (4704 is RED reagent, product photo is default provided by supplier)
Abcam p53 Human Immunocapture Kit.
p53 Human Immunocapture Kit.
The product is subject to the following: Abcam Restricted Use Statement