Apoptosis Reagents and Kits
AdipoGen Raptinal,Chemical. CAS: 1176-09-6
Raptinal, AdipoGen Life Sciences. Chemical. CAS: 1176-09-6. Formula: C28H18O2. MW: 386.4. Rapid apoptosis inducer that initiates intrinsic pathway caspase-dependent apoptosis within minutes in multiple cell lines and in vivo systems. Exerts anticancer activity in vivo, likely through the induction of apoptosis. Induces cell death against various cancer and non-cancerous cell lines with 24 hour IC50 values between 0.7-3.4?M indicating activity across a wide range of cell lines. Activates the intrinsic pathway and requires functional mitochondria for apoptosis induction. Treated cells did not undergo mitochondrial-permeability-transition-pore (MPTP) formation, suggesting a mitochondrial outer membrane permeabilization (MOMP) model of cytochrome c release.
Abcam beta-Sitosterol, Antitumor agent, 1G
MW 414.7 Da, Purity >98%. Plant sterol. Various pharmacological effects. Antitumor agent. Activates caspase 3 and induces G2/M arrest and DNA fragmentation. Increases α-tubulin levels and promotes microtubule polymerization. Inhibits dietary cholesterol absorption in vivo. Orally active.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology Caspase-10 Rabbit pAb
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Abcam Boc-D-FMK, caspase inhibitor, 5MG
MW 263.26 Da. Irreversible general caspase inhibitor. Blocks hepatocyte apoptosis in vivo. Active in vitro and in vivo. Cell-permeable.
The product is subject to the following: Abcam Restricted Use Statement
Biotium Apoptosis and Necrosis Quantitation Kit Plus (50 assays)
The Apoptosis and Necrosis Quantitation Kit Plus is a simple, convenient assay for quantifying apoptotic (green; Abs/Em: 490/515 nm) and necrotic (red; Abs/Em with DNA: 528/617 nm) cells within the same cell population by flow cytometry or fluorescence microscopy. Apoptosis is accompanied by phosphatidylserine (PS) translocation from the inner to the outer leaflet of the plasma membrane. Exposed PS is recognized by Annexin V, a calcium-dependant high-affinity phospholipid-binding protein. CF488A conjugated Annexin V stains apoptotic cells green. CF488A is spectrally similar to fluorescein (FITC), but is brighter and more photostable. Necrosis results from severe cellular injury causing loss of plasma membrane integrity. Ethidium homodimer III (EthD-III), a membrane impermeant high-affinity DNA binding dye stains cells with compromised membranes red. It is superior option to propidium iodide (PI) or ethidium homodimer I due to higher DNA affinity and fluorescence quantum yield.
CPC Scientific Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Ala-Asp-CHO 1MG
ONE-LETTER SEQUENCE: Ac-AAVALLPAVLLALLAPVAD-CHOMOLECULAR FORMULA: C88H151N19O22MOLECULAR WEIGHT:1827.3STORAGE CONDITIONS: -20 5CRESEARCH AREA: ApoptosisREFERENCES: N.A. Thornberry, and Y. Lazebnik, Science 281, 1312 (1998); Y-Z Lin, et al., J. Biol. Chem., 271, 5305 (1996); Y-Z Lin, et al., J. Biol. Chem., 270, 14255 (1995)
Abcam Z-VDVAD-FMK, caspase-2 inhibitor, 1MG
MW 695.7 Da. Z-VDVAD-FMK, caspase-2 inhibitor. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Z-ATAD-FMK, Caspase-12 inhibitor, 5MG
MW 540.54 g/mol, Purity >95%. Specific caspase-12 inhibitor. Suppresses annular cell apoptosis and caspase-9 activity in vitro. Active in vitro and in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Sigma Aldrich Fine Chemicals Biosciences Annexin V from human place1MG
Annexin V from human place1MG
Biolegend PerCP/Cyanine5.5 Annexin V
PerCP/Cyanine5.5 Annexin V Reactivity: All mammalian species; Apps: FC; Size: 100 tests
Abcam Human MAP2K2 (MEK2) knockout HEK-293T cell lysate.
Human MAP2K2 (MEK2) knockout HEK-293T cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human HINT1 knockout HeLa cell lysate.
Human HINT1 knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human CAPN2 (Calpain 2) knockout HEK-293T cell lysate.
Human CAPN2 (Calpain 2) knockout HEK-293T cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human LBR (Lamin B Receptor) knockout HEK-293T cell lysate.
Human LBR (Lamin B Receptor) knockout HEK-293T cell lysate.
The product is subject to the following: Abcam Restricted Use Statement