Apoptosis Reagents and Kits
Abcam Apoptosis Activator 2 (AAII), Cytochrome c caspase activator and apoptosis inducer, 50MG
MW 306.1 Da, Purity >99%. Cell-permeable cytochrome c caspase activator. Promoting cytochrome-c dependent oligomerization of Apaf-1 into the mature apoptosome. Induces apoptosis in tumor cells (IC₅₀ = ~4 μM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human ATG10 knockout HeLa cell lysate.
Human ATG10 knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Biotium Annexin V, CF350 Conjugate
Annexin V fluorescent conjugates can be used to detect apoptotic cells. The human anticoagulant Annexin V is a 35-36 kDa calcium-dependent phospholipid-binding protein with high affinity for phosphatidylserine (PS). In normal viable cells, PS is located on the inner leaflet of the cytoplasmic membrane. In apoptotic cells, however, PS is translocated from the inner to the outer leaflet of the plasma membrane, where it can be detected by fluorescently labeled Annexin V. CF Dye Annexin V Conjugates are provided at 50 ug/mL in buffer with azide as a preservative. CF dyes are Biotium's line of next-generation fluorescent dyes with advantages in brightness, photostability, and conjugate specificity compared to other fluorescent dyes. UV-excitable blue fluorescent CF350 dye has excitation/emission at 347/448 nm.
Abcam Hinokitiol, Iron chelator antio x idant, 250MG
MW 164.2 Da, Purity >98%. Iron chelator antioxidant. Inhibits UVB-induced apoptosis. Cytotoxic to cancer cells. Antioxidant, anti-inflammatory and antitumor. Active in vivo and in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC N-carbobenzoxy-D-homoserine | 41088-85-1 | MFCD12545887 | 253.25 g/mol | C12H15NO5 | 5 G
N-Carbobenzoxy-D-homoserine (N-(Benzyloxycarbonyl)-D-homoserine) is the D-enantiomer of homoserine bearing an N-carbobenzoxy (Cbz) protecting group. Supplied as a powder, it is used as a synthetic intermediate in organic and peptide synthesis, including preparation of antibody-drug conjugates and other constructs that require temporary N-protection.
- Powdered synthetic intermediate for organic synthesis.
- Contains N-carbobenzoxy (Cbz) protecting group for the amino function.
- Suitable for peptide synthesis and antibody-drug conjugate payload or linker preparation.
- Molecular formula C12H15NO5; molecular weight 253.25 g/mol.
- Recommended storage: powder -20°C for long term, 4°C for short term.
Abcam Z-ATAD-FMK, Caspase-12 inhibitor, 1MG
MW 540.54 g/mol, Purity >95%. Specific caspase-12 inhibitor. Suppresses annular cell apoptosis and caspase-9 activity in vitro. Active in vitro and in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Biotium Apoptotic, Necrotic & Healthy Cells Quantitation Kit Plus (50 assays)
This kit provides a convenient assay for quantifying apoptotic (green) and necrotic (red) cells within the same cell population by flow cytometry or fluorescence microscopy. The kit contains Annexin V labeled with CF488A which binds to apoptotic cells by binding to phosphatidylserine (PS) exposed on the cell surface, and Ethidium Homodimer III (EthD-III) which is a membrane impermeant nucleic acid probe specific for dead cells. Staining is rapid, requiring only a single 15-30 minute staining step. CF488A Annexin V has an excitation emission of 490/515 nm and is brighter and more photostable than FITC Annexin V. EthD-III has an excitation/emission of 522/593 nm (and a large absorption peak at 279 nm) when bound to DNA. The kit also contains a membrane permeable DNA dye Hocechst 3342 to stain all cell nuclei blue for analysis of healthy cells. The kit has reagents sufficient reagent for 50 assays.
Abcam Human PODXL knockout HCT116 cell lysate.
Human PODXL knockout HCT116 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human ENG (CD105) knockout HeLa cell lysate.
Human ENG (CD105) knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Eurofins Discoverx KILR ARH-77 (Human) Cytotoxicity Assay Kit (cell pool)
The KILR ARH-77 (Human) Stable Cell Line Cytotoxicity Assay utilizes the engineered stable target cell line that is used to measure direct death mediated by immuno-oncology treatments via ADCC, CDC, and ADCP. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Abcam Bisdemetho x ycurcumin, Apoptotic curcuminoid, 5MG
MW 308.33 g/mol, Purity >98%. Apoptotic anticancer, anti-inflammatory and antioxidant curcuminoid. Inhibits wnt activity through activation of WIF-1. Induces demethylation through DNA methyltransferase 1 inhibition. Potent and competitive aldo-keto reductase inhibitor (Ki = 22 nM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human SLC3A2 (CD98) knockout HeLa cell lysate.
This product is for research use only and not for diagnostic or therapeutic procedures. Customer is granted a limited, non-exclusive license for internal research and shall not attempt to reverse engineer.
Human SLC3A2 (CD98) knockout HeLa cell lysate.
ABclonal Technology Annexin A4/Annexin IV Rabbit pAb
Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene.
Abcam Human CDKN1C (p57 Kip2) knockout HeLa cell lysate.
Human CDKN1C (p57 Kip2) knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human TGFB1 (TGF beta 1) knockout A549 cell lysate.
Human TGFB1 (TGF beta 1) knockout A549 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement