General Clinical Chemistry Analyzers and Accessories
Abcam CCT-251921, 1MG
MW 410.9 Da, Purity >=98%. CCT-251921 is a potent, selective, small-molecule modulator of the mediator complex-associated kinases CDK8 and CDK19 (IC₅₀, CDK8 = 2.3 nM; CDK19 = 2.6 nM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam SB742457 (Intepirdine), 5-HT6 antagonist, 25MG
MW 353.4 Da. Potent (pKi = 9.63) and highly selective 5-HT6 antagonist. Greater thsan 100-fold selective against other receptors. Reverses learning impairment in animal models.
The product is subject to the following: Abcam Restricted Use Statement
Hach Company Cell Cap for 5500sc Silica and Phosphate Analyzers (Replacement spare for colorimeter cell)
Hach cell cap (MPN 6767800) is a replacement cap designed for the 5500sc silica and phosphate analyzers. It covers and helps protect the analyzer's colorimeter cell and is intended as a maintenance spare for replacement when the original cap is damaged or worn.
- Replacement cap for colorimeter cell.
- Helps protect optical surfaces from contamination.
- Intended as a maintenance spare for affected analyzers.
Abcam GSK2656157, 25MG
MW 416.5 Da, Purity >=98%. Potent and selective PERK inhibitor (IC₅₀ = 0.9 nM in cell-free assay). ATP-competitive. Exibits 500-fold selectivity for PERK versus a panel of 300 kinases.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Thifluzamide
Chemical. CAS 130000-40-7. Formula C13H6Br2F6N2O2S. MW 528.1. Synthetic. Thiazole fungicide used in agrochemistry. Succinate dehydrogenase inhibitor SDHI which interferes with succinate ubiquinone reductase in the mitochondrial electron transport chain of fungi.Compound can be used as analytical reference material.
Abcam SGI1776, 5MG
MW 405.4 Da, Purity >99%. Novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM, 50- and 10-fold selective versus Pim2 and Pim3. Preliminary results from studies treating prostate cancer cells.
The product is subject to the following: Abcam Restricted Use Statement
Med Vet International Lactated Ringer'S Injection, Sterile Nonpyrogenic Solution, 5000mL, 2/Case
VET LICENSE NEEDS TO BE PROVIDED IN 3-4 BUSINESS DAYS OR ORDER WILL BE CANCELLED
Lactated Ringers Injection is indicated as a source of water and electrolytes or as an alkalinizing agent.
Abcam Ro 08-2750, 10MG
MW 270.24 Da, Purity =98%. An antagonist of nerve growth factor (NGF) with binding ratio of 1:1, IC₅₀ = 1 μM. Selectively inhibits binding to p75NTR over TRKA147 at low concentrations. However, it can impair NGF binding to TrkA at higher concentrations (more than 5 mM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam ML-385, 5MG
MW 511.6 Da, Purity >=98%. A potent and selective Nrf2 inhibitor (Nrf2; IC₅₀ = 1.9 μM). ML-385 blocks Nrf2 downstream target gene expression. ML-385 displays specificity and selectivity for NSCLC cells with KEAP1 mutation, which leads to gain of Nrf2 function.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Ticagrelor, P2Y12 receptor antagonist, 25MG
MW 522.6 Da, Purity >98%. Reversible antagonist of the platelet purinergic P2Y12 receptor, the main receptor responsible for ADP-induced platelet aggregation. Changes the conformation of the P2Y12 receptor, resulting in reversible, concentration dependent inhibition of the receptor.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Amisulbrom
Chemical. CAS 348635-87-0. Formula C13H13BrFN5O4S2. MW 466.31. Synthetic. Oomycete-specific sulphonamide fungicide which acts by inhibiting mitochondrial complex III activity Complex III cytochrome bc1 ubiquinone reductase through binding to the Qi centre and impairing respiration and energy production. Categorized as quinine insider inhibitor QII. Shown to have anti-fouling activity. Compound can be used as analytical reference material.
AdipoGen Z-VAD-FMK Cell permeable
Chemical. CAS 187389-52-2 and 634911-81-2. Formula C22H30FN3O7. MW 467.5. Synthetic. Cell permeable, non-selective broad-spectrum caspase inhibitor. Binds irreversibly to the catalytic site of caspase proteases. The peptide is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction. Decreases proteasome activity. Potent inhibitor of caspase-1 activation in NLRP3/NALP3-induced cells. Used in apoptosis and inflammasome studies.
Abcam UC2288, p21 inhibitor, 5MG
MW 481.8 Da, Purity >98%. Cell-permeable, phenylcyclohexyl-urea based compound that selectively downregulates the expression of p21, independent of p53 expression, at either transcription or post-transcriptional level. Attenuates p21 protein levels with minimal effect on p21 protein stability. Has no significant effect on the activities of Raf kinases, VEGFR2 kinase, or the phosphorylation state of ERK. Effectively inhibits the growth of multiple cancer cell lines (GI₅₀ = ~ 10 μM against NCI60 cell lines).
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Dienogest
Chemical. CAS 65928-58-7. Formula C20H25NO2. MW 311.42. Synthetic. Dienogest is an agonist of the progesterone receptor PR. It is an orally active synthetic progestogen with approximately 10% of the relative affinity of progesterone. However it shows very potent progestagenic effects in the endometrium with some antiandrogenic activity and without any androgenic, glucocorticoid or mineralocorticoid effects. It has been used alone or in combination as a contraceptive and to treat uterine fibroids. Dienogest inhibits ovulation primarily through peripheral action rather than by central action on gonadotrophin secretion. Unlike other progestogens, except in the case of its strong effects in the uterus, dienogest is said to lack antiestrogenic effects, and does not antagonize the beneficial effects of estradiol, for instance in the metabolic and vascular systems.
Anton Paar For combined laser diffraction and dynamic image analysis measurements.Dispersion unit combining laser diffraction with dynamic image analysis.Laser diffraction measurement range from 10 nm to 2500 µm.
LIQUID FLOW IMAGING DISPERSION UNITFor combined laser diffraction and dynamic image analysis measurements.Dispersion unit combining laser diffraction with dynamic image analysis.Laser diffraction measurement range from 10 nm to 2500 µm.Camera detection range from 5 µm to 2500 µm.Integrated ultrasonication to disperse particles in liquid medium.Flexible working volume: 150-600 mL.Automated filling, rinsing, and draining.Minimum requirements to run:- outflow of the liquid (wastewater disposal connection ora tank)Recommended requirements to run:- water supply 0.1 - 3 bar