General Clinical Chemistry Analyzers and Accessories
Abcam GSK2656157, 5MG
MW 416.5 Da, Purity >=98%. Potent and selective PERK inhibitor (IC₅₀ = 0.9 nM in cell-free assay). ATP-competitive. Exibits 500-fold selectivity for PERK versus a panel of 300 kinases.
The product is subject to the following: Abcam Restricted Use Statement
Abcam CCT128930, 50MG
MW 341.8 Da, Purity =98%. Potent and selective AKT2 inhibitor (IC50= 6 nM) with selectivity greater than 28-fold and 20-fold over PKA kinase (IC50= 168 nM) and p70S6K (IC50= 120 nM), respectively.
The product is subject to the following: Abcam Restricted Use Statement
Anton Paar For liquid measurements in water, various liquids including aggressive solvents.Dispersion unit with integrated ultrasonication to disperse particles in liquid medium (up to 2500 µm).
LIQUID FLOW CHEMICAL DISPERSION UNITFor liquid measurements in water, various liquids including aggressive solvents.Dispersion unit with integrated ultrasonication to disperse particles in liquid medium (up to 2500 µm).Flexible working volume: 150-600 mL.Automated filling, rinsing, and draining.Increased chemical resistance.Minimum requirements to run:- outflow of the liquid (wastewater disposal connection or a tank)Recommended requirements to run:- water supply 0.1 - 3 bar
Abcam Daclatasvir (BMS-790052), HCV NS5A protein inhibitor, 5MG
MW 738.9 Da, Purity =97%. Daclatasvir a potent, direct acting, small molecule inhbitor of HCV NS5A protein. It inhbibits replicons expressing a wide range of HCV genotypes with EC₅₀ values in the pM range (9 and 71 pM against the 1b and 2a genotypes, respectively). It also inhibits infection by the JFH-1 genotype 2a virus in cultured cells. Daclatasvir is thought to inhibit relication of the HCV viral genome by affecting the subcellular localization of HCV NS5A and preventing its incorporation into relication complexes. In HCV-infected Huh7 cells, Daclatasvir (1 nM) inhibits viral RNA synthesis and viron assembly. Daclatasvir displays moderate activity against the OAT1B1 (IC₅₀ = 1.5 μM) and OAT1B3 (IC₅₀ = 3.27 μM) organic anion transporters.
The product is subject to the following: Abcam Restricted Use Statement
Abcam INDY, DYRK1A/B inhibitor, 5MG
MW 235.3 Da, Purity >98%. Potent DYRK1A/B inhibitor (IC₅₀ values are 0.23 and 0.24 μM for DYRK1B and DYRK1A respectively). Also inhibits DYRK2, DTRK4, CLK1, CLK4, casein kinase 1 and PIM1 (> 90% inhibition at 10 μM). Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of neural stem cells and glioblastoma tumor-initiating cells.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Apremilast, 5MG
MW 460.5 Da, Purity >98%. Ppotent PDE4 (phosphodiesterase 4) inhibitor (IC₅₀ = 74 nM). It reduces TNF-α production in human synovial cells and significantly suppresses experimental arthritis.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GLPG-1690, 25MG
MW 588.7 Da, Purity >=98%. Selective autotaxin inhibitor with potential application in idiopathic pulmonary disease (IPF).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Dinaciclib, cyclin-dependent kinase (CDK) inhibitor, 5MG
MW 396.5 Da, Purity >98%. Novel, potent, selective cyclin-dependent kinase (CDK) inhibitor displaying selectivity for CDK1, CDK2, CDK5 and CDK9 (IC₅₀ values are 3, 1, 1 and 4 nM respectively). Potent DNA replication inhibitor that blocks thymidine incorporation in A2780 ovarian cancer cells (IC₅₀ = 4 nM).
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Rilpivirine
Chemical. CAS 500287-72-9. Formula C22H18N6. MW 366.4. Rilpivirine is a non-nucleoside reverse transcriptase inhibitor NNRTI that inhibits growth of wild-type HIV with an EC50 value of 0.51nM. It is active against NNRTI-resistant HIV strains with EC50 values less than 1nM for L100I, K103N, V106A, G190A and G190S mutants in vitro. Rilpivirine also reduces growth of greater than 80% of 1,500 NNRTI-resistant clinical isolates EC50s = <10nM, including strains containing up to eight resistance mutations. NNRTIs work by binding to and blocking HIV reverse transcriptase, which prevents HIV from replicating and lowers the amount of HIV in the blood. Rilpivirine is an antiviral anti-HIV drug, active against wild-type and NNRTI-resistant HIV-1 with higher potency, longer half-life and reduced side-effect profile compared with Efavirenz Prod. No. AG-CR1-3751. CARD8 inflammasome senses HIV-1 protease activity.
Anton Paar For dry measurements using compressed air.Suitable for particles of up to 3500 µm (default).Pressure: 0.05-4.6 bar
DRY JET DISPERSION UNITFor dry measurements using compressed air.Suitable for particles of up to 3500 µm (default).Pressure: 0.05-4.6 bar.Sample funnel volume: 150 mL (default). Optional: 600 mL.Superior protection against sample spread.Automated feeding rate.Requires vacuum cleaner for operation.Minimum requirements to run:- Supply of compressed gas 5 - 10 bar- Compatible vacuum cleaner- 257436 Air dryer IDG 30 with air filter unit
Abcam GNE-0877, 10MG
MW 339.32 Da, Purity =98%. A potent and selective Leucine-rich repeat kinase 2 (LRRK2) inhibitor, Ki = 0.7 nM.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Nordihydrocapsiate
Chemical. CAS 220012-53-3. Formula C17H26O4. MW 294.39. Synthetic Major capsaicinoid. TRPV1 and hTRPA1 agonist. Shown to activate capsaicin receptor, also called transient receptor potential vanilloid subfamily member 1 TRPV1, but without inducing a nociceptive response. Anti-inflammatory and anticancer compound.
AdipoGen 3-oxo-C10-L-HSL
Chemical. CAS 147795-40-2. Formula C14H23NO4. MW 269.3. Synthetic. N-3-Oxodecanoyl-DL-homoserine lactone is a small diffusible signaling molecule and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones AHL are involved in quorum sensing, controlling gene expression, and cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence in general, infection prevention, and formation of biofilms. It was used as an autoinducer of quorum signaling by Pseudomonas putida, Yersinia enterocolitica and other Gram-negative bacteria.
Abcam G10, STING signaling activator, 10MG
MW 430.9 Da, Purity >98%. G10 is an indirect activator or stimulator of interferon genes (STING) signaling. It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-κB-dependent transcription of IL-8, IL-1β, or MIP-1α in human fibroblasts. However, G10 does increase expression of NF-κB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC₉₀s = 8.01 and 24.57 μM, respectively). G10 (100 μM) increases phosphorylation of IRF3, which is lost in cells lacking STING.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Sodium tetrap-tolylborate
Chemical. CAS 15738-23-5. Formula C28H28BNa. MW 398.32. Synthetic. Analytical/Chromatography reagent. Ion sensor compound. Additive for ISE.