General Clinical Chemistry Analyzers and Accessories
Abcam 7-Cl-O-Nec1, metabolically stable RIP1 inhibitor, 5MG
MW 277.7 Da, Purity >98%. Necrostatin-1 (ab141053) analog with superior selectivity and metabolic stability in blocking RIP1. No off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1. Higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC₅₀ = 210 nM vs. EC₅₀ = 490 nM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Ledipasvir, 5A of hepatitis C virus inhibitor, 500UG
MW 889 Da. Ledipasvir is an inhibitor of non-structural protein 5A of hepatitis C virus. It has potent effects against genotypes 1a, 1b, 4a, and 5a in vitro, but has lower activity against genotypes 2a and 3a. Ledipasvir can have additive to synergistic in vitro antiviral activity when combined with other agents.
The product is subject to the following: Abcam Restricted Use Statement
Abcam BAY-299, TAF1 and BRD1 inhibitor, 10MG
MW 429.5 Da, Purity >98%. Potent and selective bromodomain inhibitor of TAF1 (IC₅₀ = 8-13 nM) and BRD1 (IC₅₀ = 6-67 nM). More than 30-fold selective versus BRD9 and ATAD2. More than 300-fold selective versus BRD4. Inhibits BRD1 (IC₅₀ = 0.58 μM) and TAF1 (IC₅₀ = 0.9 μM) binding to Histone H4 in cell-based assays; also inhibits BRD1 (IC₅₀ = 0.83 μM) and TAF1 (IC₅₀ = 1.4 μM) binding to Histone H3.3.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Sitravatinib, 5MG
MW 629.7 Da, Purity =98%. Broad spectrum receptor tyrosine kinase inhibitor (e.g. Axl, c-Met, PDGFR, VEGFR, Ephrin receptor family, and FLT3). Better efficacy in mouse models than imatinib and crizotinib.
The product is subject to the following: Abcam Restricted Use Statement
Abcam ABT-199 (Venetocla x ), Bcl-2 inhibitor., 1MG
MW 868.4 Da, Purity >98%. Potent, selective Bcl-2 inhibitor (Ki <0.01 nM) that inhibits the growth of Bcl-2–dependent tumors while sparing platelets. Bcl-2–specific BH3 mimetic. Promising agent in the treatment of chronic lymphocytic leukaemic and estrogen receptor-positive breast cancer.
The product is subject to the following: Abcam Restricted Use Statement
Abcam RITA, p53 activator, 5MG
MW 292.4 Da, Purity >98%. p53 activator. Tricyclic thiophene derivative that binds to p53 and induces its accumulation in tumor cells. Prevents p53-HDM2 (MDM2) interaction in vitro and in vivo and affects p53 interaction with several negative regulators. Induces expression of p53 target genes and apoptosis in various tumor cell lines expressing wild-type p53.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Cefpodoxime
Chemical. CAS 80210-62-4. Formula C15H17N5O6S2. MW 427.46. Synthetic. Cefpodoxime is a metabolite of cefpodoxime proxetil, an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria MIC90 ranges from 0.015-8 µg/ml. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. Cefpodoxime inhibits cell wall synthesis by inhibiting the final transpeptidation step of peptidoglycan synthesis in cell walls.
AdipoGen Etobenzanid
Chemical. CAS 79540-50-4. Formula C16H15Cl2NO3. MW 340.2. Synthetic. Herbicide. Compound can be used as analytical reference material.
Abcam Indo x imod, Indoleamine 2,3-dio x ygenase (IDO) inhibitor, 500MG
MW 218.25 Da, Purity >95%. Methylated tryptophan which acts as an Indoleamine 2,3-dioxygenase (IDO) inhibitor. Prevents T-cell anergy triggered by dendritic cells overexpressing IDO in mice.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Mefluidide
Chemical. CAS 53780-34-0. Formula C11H13F3N2O3S. MW 310.3. Synthetic. Trifluoromethanesulphonanilide herbicide. Plant growth regulator based on the inhibition of distinct 3-ketoacyl-CoA synthase KCS isoenzymes in very-long-chain fatty acid VLCFA synthesis. Dependent on the affected KCS isoenzymes and the intensity of inhibition, plant phenotypes are induced which are characterized by shoot stunting with intensified green pigmentation or strong growth inhibition followed by tissue necrosis and plant death. Compound can be used as analytical reference material.
Abcam TC 14012, Peptidomimetic C x CR4 antagonist, 1MG
MW 2066.4 Da, Purity >95%. TC 14012, Peptidomimetic CXCR4 antagonist. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen 3-Acetyl-6-bromocoumarin
Chemical. CAS 2199-93-1. Formula C11H7BrO3. Molecular Weight 267.1. An intermediate for organic synthesis. Shown to display semiconductor behaviour.
AdipoGen Monosultap
Chemical. CAS 29547-00-0. Formula C5H12NNaO6S4. MW 333.4. Synthetic. Nereistoxin analog insecticide. Insect nicotinic acetylcholine receptors nAChRs channel blocker. Compound can be used as analytical reference material.
Abcam HDM-201 (Siremadlin), 5MG
MW 555.4 Da, Purity >=98%. Potent and highly specific MDM-2/p53 inhibitor. It binds to human MDM2 protein with a picomolar Ki value (0.21 nM). It activates p53 and induces robust p53-dependent cell cycle arrest and apoptosis in human p53 wild-type tumor cells.
The product is subject to the following: Abcam Restricted Use Statement
Abcam BAY-299, TAF1 and BRD1 inhibitor, 1MG
MW 429.5 Da, Purity >98%. Potent and selective bromodomain inhibitor of TAF1 (IC₅₀ = 8-13 nM) and BRD1 (IC₅₀ = 6-67 nM). More than 30-fold selective versus BRD9 and ATAD2. More than 300-fold selective versus BRD4. Inhibits BRD1 (IC₅₀ = 0.58 μM) and TAF1 (IC₅₀ = 0.9 μM) binding to Histone H4 in cell-based assays; also inhibits BRD1 (IC₅₀ = 0.83 μM) and TAF1 (IC₅₀ = 1.4 μM) binding to Histone H3.3.
The product is subject to the following: Abcam Restricted Use Statement