General Clinical Chemistry Analyzers and Accessories
Abcam Furamidine dihydrochloride, 5MG
MW 304.3 Da, Purity >=98%. A potent, selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor (IC₅₀ = 9.4 μM). Displays selectivity over PRMT5, PRMT6 and CARM1 (IC₅₀ values are 166, 283 and >400 μM respectively). Inhibits cell proliferation in leukemia cell lines.
The product is subject to the following: Abcam Restricted Use Statement
Abcam CCT-251921, 1MG
MW 410.9 Da, Purity >=98%. CCT-251921 is a potent, selective, small-molecule modulator of the mediator complex-associated kinases CDK8 and CDK19 (IC₅₀, CDK8 = 2.3 nM; CDK19 = 2.6 nM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Qstatin, 25MG
MW 293.2 Da, Purity >=98%. A potent, and selective Vibrio QS inhibitor which affects Vibrio harveyi LuxR homologues, the well-conserved master transcriptional regulators for QS in Vibrio species. QStatin binds tightly to a putative ligand-binding pocket in SmcR, the LuxR homologue in V. vulnificus, and changes the flexibility of the protein, thereby altering its transcription regulatory activity.
The product is subject to the following: Abcam Restricted Use Statement
Abcam IWP-4, 50MG
MW 496.6 Da, Purity >98%. Potent inhibitor of Wnt pathway regulatory protein porupine (Porcn). Blocks Wnt protein secretion and prevents the canonical and non-canonical signaling pathways. Blocks palmitylation, and subsquent secretion and activity of Wnt. Induces differentiation of cardiomyocytes from human ESCs and iPSCs.
The product is subject to the following: Abcam Restricted Use Statement
Abcam TW-37, 100MG
MW 573.7 Da, Purity >98%. Small-molecule inhibitor of BCL-2 (Ki = 0.29 μM). Inhibits multiple BCL-2 family members including BCL-XL (Ki = 1.11 μM) and MCL-1 (Ki= 0.26 μM). Binds to the BCL-2 homology domain 3 (BH3) groove of BCL-2. Significant anti-proliferative and pro-apoptotic activity in lymphoma cells.
The product is subject to the following: Abcam Restricted Use Statement
Abcam CCT128930, 5MG
MW 341.8 Da, Purity =98%. Potent and selective AKT2 inhibitor (IC50= 6 nM) with selectivity greater than 28-fold and 20-fold over PKA kinase (IC50= 168 nM) and p70S6K (IC50= 120 nM), respectively.
The product is subject to the following: Abcam Restricted Use Statement
Perkin Elmer US LLC Sipper Cell and Pump Accessory
The Sipper Cell and Pump Accessory measures large numbers of liquid samples quickly and accurately. Samples can be transferred from a wide variety of containers to the flow cell. Includes: Synthetic Fused Silica flow cell, pathlength: 1.3 mm, cell volume: 16 mL (L2151247) Peristaltic pump controlled by computer Standard fitting 0.4 mm FEP Inlet Tube (L2151202) 0.7 mm FEP Outlet Tube (L2151203) Please note: This accessory requires installation by a PerkinElmer service engineer, not included.
Hach Company Cell Cap for 5500sc Silica and Phosphate Analyzers (Replacement spare for colorimeter cell)
Hach cell cap (MPN 6767800) is a replacement cap designed for the 5500sc silica and phosphate analyzers. It covers and helps protect the analyzer's colorimeter cell and is intended as a maintenance spare for replacement when the original cap is damaged or worn.
- Replacement cap for colorimeter cell.
- Helps protect optical surfaces from contamination.
- Intended as a maintenance spare for affected analyzers.
Abcam D-Gluconic acid, methyl ester, 50MG
MW 210.18 g/mol. Membrane permeant analog of D-gluconic acid. Useful as a component of cell culture media; enzymatic degradation of xylan and glucomannan; various pharmaceutical preparations; as well as an intermediate in carbohydrate based synthetic preparations of sugar derivatives.
The product is subject to the following: Abcam Restricted Use Statement
Abcam P 22077, 50MG
MW 315.3 Da, Purity >98%. Selective USP7 (IC₅₀ = 8 μM) inhibitor. Active against closely related USP47. Selective versus SENP2c0re (IC₅₀ >50 μM) and DENI (IC₅₀ >50 μM). Destabilizes Claspin. Inhibits neuroblastoma growth by inducing p53-mediated apoptosis. Inhibits Tip60 deubiquitination.
The product is subject to the following: Abcam Restricted Use Statement
Abcam TW-37, 50MG
MW 573.7 Da, Purity >98%. Small-molecule inhibitor of BCL-2 (Ki = 0.29 μM). Inhibits multiple BCL-2 family members including BCL-XL (Ki = 1.11 μM) and MCL-1 (Ki= 0.26 μM). Binds to the BCL-2 homology domain 3 (BH3) groove of BCL-2. Significant anti-proliferative and pro-apoptotic activity in lymphoma cells.
The product is subject to the following: Abcam Restricted Use Statement
Abcam E7820, 25MG
MW 336.4 Da, Purity >=98%. A small molecule sulfonamide derivative with potential antiangiogenic and antitumor activities. E7820 inhibits angiogenesis by suppressing integrin alpha 2, a cell adhesion molecule expressed on endothelial cells. Inhibition of integrin alpha 2 leads to an inhibition of cell-cell interactions, endothelial cell-matrix interactions, vascular endothelial cell proliferation and angiogenesis.
The product is subject to the following: Abcam Restricted Use Statement