Custom Peptides
Cayman Chemical PAR21-6 amIdehumntrI 10mg
A peptide agonist of PAR2; binds to NCTC 2544 cells expressing human PAR2 (Ki = 9.64 µM in a radioligand binding assay) and induces calcium mobilization in the same cells (EC50 = 0.075 µM); reduces colony formation of A549 cells at 100 µM; induces superoxide production and degranulation in isolated human eosinophils at 500 µM; induces tear secretion in rats at 5 µmol/kg when used in combination with amastatin
Cayman Chemical ArundIc AcId 10mg
An inhibitor of astrocyte activation; reduces increases in brain GFAP and S100β levels in a rat model of permanent focal ischemia induced by middle cerebral artery occlusion at 10 mg/kg; decreases the number of TUNEL-positive neurons, reduces infarct size, and improves motor performance in the rotarod test in the same model at 3 and 10 mg/kg; also reduces descent time and time to turn in a pole test in a mouse model of MPTP-induced Parkinson's disease at 30 mg/kg
Cayman Chemical NGB 2904hydrochlorIde 10mg
A selective dopamine D3 receptor antagonist (Ki = 1.4 nM); attenuates cocaine- and stress-induced reinstatement of drug-seeking behavior in rats
Cayman Chemical SulfatIdebovInsodIum sa 10mg
A mixture of isolated bovine sulfatides; found in the central and peripheral nervous systems, pancreas, and immune system; primarily found in myelin; the ceramide portion contains variable fatty acid chain lengths, which are tissue- and pathology-dependent; accumulate in the lysosome of patients with metachromatic leukodystrophy
Cayman Chemical 4-CABhydrochlorIde 10mg
An analog of PCA; inhibits the reuptake of serotonin (IC50 = 330 nM) and dopamine (IC50 = 2.3 μM)
Cayman Chemical OmadacyclIn 10mg
An aminomethylcycline antibiotic; active against tetracycline-susceptible and -resistant strains of S. aureus, E. faecalis, E. faecium, S. pneumoniae, and E. coli, as well as β-hemolytic streptococci (MICs = ≤0.06-2 UG/ml); efficacious in mouse models of systemic infection with tetracycline-sensitive and -resistant strains of S. pneumoniae, S. aureus, or E. coli (ED50s = 0.3-3.34 mg/kg)
Cayman Chemical 1 2DImyrIstoyld54snglycer 10mg
An internal standard for the quantification of 1,2-dimyristoyl-sn-glycero-3-PC by GC- or LC-MS
Cayman Chemical SynthetIc RIcInIn 10mg
A piperidine alkaloid with diverse biological activities; an inhibitor of AChE (IC50 = 54.5 UG/ml); scavenges ABTS radicals and chelates iron (IC50s = 102.65 and 104.32 UG/ml, respectively); toxic to adult A. gambiae at 0.04 mg/ml in a feeding assay; toxic to mice (LD50s = 340 and 3,000 mg/kg for oral and i.p. administration, respectively); has been used as a biomarker of ricin poisoning
Cayman Chemical AlocryptopIn 10mg
An isoquinoline alkaloid; active against S. aureus, P. aeruginosa, and E. coli (MICs = 250, 125, and 125 UG/ml, respectively), P. falciparum and E. histolytica (IC50s = 5.08 and 135 µM, respectively), and a panel of seven phytopathogenic fungi (IC50s = 15.2-42.4 UG/ml)
Cayman Chemical Takeda-103A 10mg
A GRK2 inhibitor; selectively inhibits phosphorylation of bovine rod outer segments by GRK2 (IC50 = 54 nM) over phosphorylation by GRK1 and GRK5 at concentrations up to 125 µM; inhibits phosphorylation of bovine rod outer segments by GRK2 containing various mutations, including GRK2L271M, GRK2Y206S, GRK2I197L, and GRK2L235G (IC50s = 24, 55, 106, and 180 nM, respectively)
Cayman Chemical 11-deoxy ProstaglndIn F2a 10mg
11-deoxy PGF2α is a synthetic analog of PGF2α. It is a more potent agonist than PGF2α at inducing smooth muscle contractions of rabbit aorta, dog saphenous vein, and guinea pig trachea.{2260} It is approximately 20% less potent than U-46619.{2260}
Cayman Chemical CID-2858522 10mg
A selective inhibitor of PKC-induced NF-κB pathway activation (IC50 = 0.07 μM); inhibits IL-8 production in HEK293 cells (IC50 ≤ 0.1 μM), attenuates production of IL-2 by Jurkat T cells (IC50 ≤ 5 μM), and prevents proliferation of mouse B-lymphocytes (IC50 = ∼2 μM)
Cayman Chemical LCL-161phenol 10mg
A derivative of LCL-161 and a PROTAC synthetic intermediate; has been used in the synthesis of PROTACs that drive degradation of androgen receptors
Cayman Chemical HexnolamIno PAF C-16 10mg
Hexanolamino PAF C-16 is a PAF analog with mixed PAF receptor agonist/antagonist properties. In human monocyte-derived macrophages, it is an antagonist which inhibits the production of reactive oxygen species in response to PAF C-16.{367} On the other hand, in rabbit platelets and guinea pig macrophages, hexanolamino PAF C-16 is a partial agonist, and in guinea pig platelets it is a full agonist.{3786}