Custom Peptides
Cayman Chemical IsocarboxazId 10mg
An inhibitor of MAO (IC50 = 4.8 μM for rat brain MAO); induces a 4-fold increase in tryptamine action in isolated rat fundal strips at a concentration of 50 nM; potentiates tryptamine toxicity (LD50 = 8 mg/kg following subcutaneous administration of 250 mg/kg tryptamine; inhibits 90% of MAO activity in isolated rat hearts and reduces isoproterenol-induced cardiomegaly in rats; increases levels of dopamine and norepinephrine and reduces levels of the monoamine metabolites DOPAC, HVA, and 5-HIAA in mouse brain
Cayman Chemical L-hydroxy ArgInInacetate 10mg
A substrate for NOS in the formation of NO; as been used as a biomarker for reduced NO formation in patients with cardiovascular disease and metabolic syndrome
Cayman Chemical NorsufentnIl 10mg
A metabolite of sufentanil, produced by oxidative N-dealkylation in the liver by CYP450 isoforms; intended for forensic applications
Cayman Chemical NDesethylamIodaronhydroch 10mg
the major CYP3A4 metabolite of amiodarone; used as an analytical reference standard for monitoring clinical efficacy of amiodarone in plasma samples
Cayman Chemical Thromboxn B2 10mg
An inactive metabolite of TXA2; serum levels positively correlate with platelet COX-1 activation; urinary levels reflect intrarenal TXA2 synthesis
Cayman Chemical JWH398 2CLORNaphthyl Isom 10mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids; intended for research and forensic applications
Cayman Chemical JWH 251 4mthylphnyl IsomR 10mg
Differs from JWH 251 by having the methyl group at the 4 position, rather than the 2 position, on the phenyl group
Cayman Chemical 1 2bIs heptnoylthIo GlycR 10mg
Diheptanoyl Thio-PC is a substrate for all PLA2s with the exception of cPLA2 and PAF-AH.{5681} Interaction of this compound with a PLA2 results in cleavage of the sn-2 fatty acid generating a free thiol on the lysophospholipid. This free thiol can be detected using chromogenic substrates such as DTNB (Ellman’s reagent) and DTP.{1358,1359}
Cayman Chemical JWH398 6CLORNaphthyl Isom 10mg
An analytical reference standard that is structurally similar to known synthetic cannabinoids; intended for research and forensic applications
Cayman Chemical CaMKII-IN-1 10mg
A CaMKII inhibitor (IC50 = 0.063 µM); is selective for CaMKII over CaMKIV, MLCK, p38α, Akt1, and PKC (IC500s = >60, 36, 11, 30, and 21 µM, respectively)
Cayman Chemical PPACKhydrochlorIde 10mg
A synthetic peptide derivative that irreversibly and specifically inhibits thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki = 0.24 nM); used as an anticoagulant (100 μM)
Cayman Chemical GnoderenIc AcId D 10mg
A triterpenoid with diverse biological activities; inhibits ACE (IC50 = 734 µM); cytotoxic to HepG2, HeLa, and Caco-2 cancer cells (IC50s = 0.14, 0.18, and 0.26 mg/ml, respectively); inhibits LPS-induced NO production in BV-2 microglia (IC50 = 13.77 µM)
Cayman Chemical MInoxIdIl Sulfate 10mg
A hair follicle stimulator and an active metabolite of minoxidil; binds to KATP channels in a biphasic manner in COS-7 cells expressing the human channel (IC50s = 0.62 and 0.96 µM); induces vasodilation in isolated rabbit mesenteric artery at 5 µM
Cayman Chemical aContoxIn ImItrIfluoroace 10mg
A conotoxin and an antagonist of α7 nAChRs (IC50 = 220 nM); selective for α7 nAChRs over α2β2, α3β2, α4β2, α2β4, α3β4, α4β4, and α1β1γδ subunit-containing nAChRs at 5 µM but does inhibit homomeric α9 nAChRs (IC50 = 1,800 nM); administration of paclitaxel in micelles containing α-conotoxin ImI decreases tumor growth in an MCF-7 mouse xenograft model; intracerebroventricular administration of α-conotoxin ImI induces seizures in rats at 20 nmol/animal