Custom Peptides
Cayman Chemical 8- 3-ChlorostyrylcaffeIn 10mg
An adenosine A2 receptor antagonist (Ki = 54 nM); selective for adenosine A2 over A1 receptors (Ki = 28 µM); reverses APEC-induced locomotor depression in mice (ED50 = 16 UG/kg, i.p.); increases locomotion in mice at 5 mg/kg; reverses L-DOPA-induced shortening of the rotational motor response and increases in striatal adenosine A2 receptor levels in a rat model of 6-OHDA-induced Parkinson's disease at 5 mg/kg; inhibits MAO-B (Ki = 100 nM); reduces MAO-B activity in brain mitochondrial preparations from wild-type and A2A-/- mice
Cayman Chemical 5 N NhexamethylenAmIlorI 10mg
An amiloride derivative with diverse biological activities; an allosteric antagonist of adenosine A2A receptors (Ki = 3.3 µM); inhibits the cation-selective ion channel formed by Vpu at 50 µM, as well as budding of virus-like particles in HeLa cells expressing the HIV-1 proteins Gag and Vpu at 10 µM; blocks the cation-selective ion channels formed by p7; induces necrosis in and reduces the viability of various breast cancer cells at 40 µM; protects against post-ischemic contractile dysfunction and reduces coronary effluent creatine phosphokinase activity in a model of ischemia-reperfusion injury using isolated rat right ventricular free walls
Cayman Chemical 4hydroxy Nonal MRcapturIc 10mg
Peroxidation of common ω-6 PUFAs such as linoleic acid, DGLA, and arachidonic acid can give rise to 4-HNE. 4-HNE is cleared rapidly from the plasma and undergoes enterohepatic circulation as a glutathione conjugate in the rat.{7334} About two thirds of an administered dose of 4-HNE is excreted within 48 hours in the urine, primarily in the form of mercapturic acid conjugates.{8626} The C-1 aldehyde of 4-HNE is reduced to an alcohol in about half of these metabolites. The remainder are C-1 aldehydes or have been oxidized to C-1 carboxylic acids. These aldehydes and carboxylic acids can also form γ-lactols and γ-lactones, respectively, producing at least 4 or 5 end urinary metabolites of 4-HNE in vivo.
Cayman Chemical 4chLRo Trazodon Isomerhy 10mg
An isomer of trazodone; inhibits apomorphine-induced stereotypy in mice (ED50 = 0.24 mg/kg); induces catalepsy in mice (ED50 = 0.9 mg/kg)
Cayman Chemical 5methoxy TryptamInhydroch 10mg
An analytical reference standard categorized as a tryptamine; intended for research and forensic applications
Cayman Chemical 8-Iso ProstaglndIn F2a 10mg
An isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids and the most frequently studied member of the isoprostane family
Cayman Chemical EtelcalcetIdehydrochLRIde 10mg
A peptide agonist of CaSR; selective for CaSR over a panel of 33 receptors and ion channels, as well as the norepinephrine transporter at 10 µM; increases intracellular calcium levels in HEK293T cells expressing the human CaSR receptor (EC50 = 0.53 µM); inhibits parathyroid secretion from primary rat parathyroid cells (EC50 = 0.36 µM in the presence of calcium); decreases parathyroid hormone and calcium in plasma and serum, respectively, in a model of chronic renal insufficiency with secondary hyperthyroidism in nephrectomized rats fed high-phosphorus diet at 0.3, 1, and 3 mg/kg
Cayman Chemical 8-NItrotryptnthrIn 10mg
A tryptanthrin derivative with diverse biological activities; inhibits human recombinant IDO1 (IC50 = 0.103 μM) and its enzyme activity in HEK293 cells expressing human IDO1 (IC50 = 0.18 μM); inhibits growth of U251, H522, M14, DU145 and A498 cancer cells (GI50s = 4.5, 4.8, 15, 8, and 2 μM, respectively); active against M. tuberculosis, MRSA, and M. furfur (MICs = 0.032, 0.5, and 5 μg/ml, respectively); active against T. brucei (EC50 = 0.24 μg/ml)
Cayman Chemical 4Methyl7 4nItro2 trIflu 10mg
A turn-on fluorescent probe for H2S; excited at 348 nm in DMSO and fluorescence intensity increases in the presence of HS-; selective for HS- over cysteine, AcO-, F-, H2PO4-, Cl-, Br-, and I- and is not cytotoxic up to a concentration of 150 UG/ml
Cayman Chemical ProcaterolhydrochlorIde 10mg
An adrenergic receptor agonist; selective for β2-ARs over β1-ARs (Kds = 46 and 4,000 pM, respectively); binds more potently to β2-ARs in isolated guinea pig lung than to β1-ARs in isolated guinea pig cardiac ventricle in the presence (IC50s = 175 and 1,660 nM, respectively) and absence of GTP (IC50s = 55.1 and 1,660 nM, respectively); inhibits acetylcholine-induced contractions in isolated guinea pig trachea (EC50 = 10.5 nM); inhibits histamine-induced airflow obstruction in a guinea pig model of ovalbumin-sensitized asthma at 10 μg/ml via inhalation
Cayman Chemical Decnoyl-L-carnItInchlorId 10mg
A derivative of L-carnitine; increases the formation of C24 fatty acid intermediates, as well as docosapentaenoic and docosahexaenoic acid in rat hepatocytes
Cayman Chemical N3hydroxybutyrylLHomoserI 10mg
An N-acyl-homoserine lactone produced by the bacterium V. splendidus; has been found in sequencing batch biofilm reactors used in wastewater treatment; racemic version of the V. harveyi autoinducer N-((R)-3-hydroxybutanoyl)-L-homoserine lactone
Cayman Chemical N 2Fluorophenthyl5 2me 10mg
An inhibitor of HIF-1 signaling (IC50 = 0.32 μM in a cell-based HRE reporter assay under hypoxic conditions); inhibits hypoxia-induced increases in HIF-1α levels in MDA-MB-231, SKOV3, and HeLa cells in a concentration-dependent manner; inhibits hypoxia-induced VEGF expression and capillary-like tube formation in HUVECs; inhibits migration and invasion of MDA-MB-231 cells in wound healing and transwell assays under hypoxic conditions; reduces lung metastasis in an MDA-MB-231 mouse xenograft model at 15 and 30 mg/kg every other day