Custom Peptides
Cayman Chemical 8-dehydro Cholesterol 10mg
An isomer of 7-DHC; accumulates in tissues and plasma in patients with SLOS; levels are increased in serum in a rat model of SLOS induced by AY 9944
Cayman Chemical 3-Methylcrotonyl GlycIn 10mg
A metabolite; found in urine of patients with 3-methycrotonyl glycinuria; inhibits CO2 production and mitochondrial complex II-III and creatine kinase activity in rat cerebral cortex preparations in a concentration-dependent manner; inhibits the Na+/K+-ATPase in purified synaptic membranes from rat cerebrum
Cayman Chemical KaempfRol 7nohSpRIdosID 10mg
A flavonoid glycoside with antioxidant and anticancer activities; scavenges DPPH radicals in a cell-free assay (IC50 = 7.4 µM); cytotoxic to A549, HepG2, and HeLa cells (IC50s = 0.53, 0.2, and 0.051 µM, respectively)
Cayman Chemical Lys05hydrochlorIde 10mg
An inhibitor of autophagy; induces p62 accumulation and increases the ratio of LC3-II to LC3-I in C8161 melanoma cells in a concentration-dependent manner; increases the number of autophagic vesicles per cell in tumors in a C8161 mouse xenograft model and reduces tumor volume and growth in a 1205Lu melanoma mouse xenograft model at 76 mg/kg; reduces tumor growth rate, volume, and weight in an HT-29 colon cancer mouse xenograft model at ≥10 mg/kg but increases bowel thickness and obstruction at 80 mg/kg
Cayman Chemical PntoIc AcId 10mg
An intermediate in the biosynthesis of D-pantothenic acid and, subsequently, CoA
Cayman Chemical Neurodazine 10mg
Induces neuronal differentiation in skeletal muscle cells, as indicated by the upregulated expression of neuron-specific markers; effective with mature muscle fibers as well as myoblasts
Cayman Chemical 5- 3 4-DIhydroxyphenylV 10mg
An active metabolite of various polyphenols; an inhibitor of MMP-1 and MMP-2 collagen degradation activity (IC50s = 108 and 106 nM, respectively), MMP-1 and MMP-9 gelatin degradation activity (IC50s = 45.2 and 17.7 nM, respectively), and MMP-2 and MMP-9 elastin degradation activity (IC50s = 61.8 and 89 nM, respectively); scavenges free radicals in a TEAC assay
Cayman Chemical BImS BH351-76humntrI 10mg
A Bim-derived peptide; binds to Mcl-1, Bcl-xL, Bcl-2, and Bcl-W (IC50s = 18, 10, 7, and 18 nM, respectively); induces cytochrome c release from mitochondria derived from bcl-x-/- MEFs
Cayman Chemical TatsyndegrontrIfluoroace 10mg
An α-synuclein knockdown peptide; binds to recombinant α-synuclein in a peptide-protein binding assay and reduces α-synuclein levels in primary rat cortical neuron cultures; reduces brain α-synuclein levels in M38 transgenic mice that overexpress human A53T mutant α-synuclein at 40 mg/kg; reduces phosphorylated α-synuclein levels in the substantia nigra and the pons, as well as neuroinflammation in a mouse model of spreading synucleinopathy; protects against dopaminergic neuron loss and rescues motor deficits in a mouse model of MPTP-induced Parkinson’s disease at 6 µmol/kg, i.p.
Cayman Chemical EHNAhydrochlorIde 10mg
A dual inhibitor of adenosine deaminase (IC50 = 1.2 μM in human red blood cells) and PDE2 (IC50s = 0.8 and 2 μM from human and pig myocardium, respectively, 3.5 μM in rat hepatocyte, and 5.5 μM in human platelet)
Cayman Chemical SynthetIc DIctamnIn 10mg
An alkaloid with diverse biological activities; inhibits arachidonic acid-, collagen-, thrombin-, or PAF-induced platelet aggregation in washed isolated rabbit platelets at 100 UG/ml; cytotoxic to human KB oral, HeLa cervical, and DLD-1 colon cancer cells (EC50s = 20.55, 2.5, and 6.4 UG/ml, respectively) and induces apoptosis in A549, PC-9, and EBC-1 human lung cancer cells from 50-200 µM; increases serum ALT and ALP activities and induces hepatocyte necrosis in mice at 150 or 200 mg/kg
Cayman Chemical 5methyl2HOBAhydrochlorId 10mg
An isoketal scavenger; reduces angiotensin II-induced increases in systolic blood pressure in mice
Cayman Chemical C8 CeramIded18 18 0 10mg
C8 Ceramide (d18:1/8:0) is a cell-permeable analog of naturally occurring ceramides. Unlike C2 ceramide, it is metabolized within cells to generate natural ceramides, often causing a dramatic increase in cellular ceramide levels. For this reason, treatment of cells with C8 Ceramide (d18:1/8:0) may more closely mimic the effects of ceramide elevation than does treatment with shorter chain ceramide analogs. C8 Ceramide (d18:1/8:0) likely mediates many diverse biological activities, as do natural ceramides. It promotes the differentiation of human keratinocytes and induces apoptosis of both human leukemia cells and the U937 cell line.
Cayman Chemical JWH 210 3ethylnaphthyl 10mg
A positional isomer of JWH 210, having the ethyl side chain at the 3 position rather than at the 4 position of the naphthyl group; intended for forensic purposes
Cayman Chemical Lersvrn 10mg
An NNRTI (mean IC50 = 118 nM for the wild-type HIV-1 enzyme); inhibits mutant HIV-1 RTs with mean IC50 values within 10-fold of the wild-type enzyme; inhibits HIV-1 virus replication in MT-2 cells (EC50s = 5.04, 13.1, and 34.9 nM at MOIs of 0.005, 0.05, and 0.5, respectively); exhibits synergistic or additive effects when used in combination with a variety of antiretroviral agents