Custom Peptides
Cayman Chemical 2DeoxycytIdIn5OtrIphos 10mg
A nucleoside triphosphate; has commonly been used in PCR reaction mixtures as a substrate for DNA synthesis by DNA polymerases
Cayman Chemical SugamadexsodIum salt 10mg
A steroid-based neuromuscular blocker reversing agent; selectively reverses rocuronium-induced neuromuscular blockade over that induced by mivacurium or atracurium in anesthetized rhesus monkeys; prevents formation of postoperative peritoneal adhesions in rats; increases the total number of neurons in the hippocampus compared to control and improves motor coordination in a beam walking test in a rat model of ischemia-reperfusion injury (16 and 100 mg/kg)
Cayman Chemical Cordyceps mIlItarIs 10mg
A nucleoside analog with diverse biological activities; is converted to cordycepin triphosphate, which inhibits ATP-dependent DNA and RNA synthesis; incorporates into DNA and RNA in SK-HEP-1 cells; is active against B. subtilis at 0.1-1 mg/ml; increases IL-10 secretion and mRNA expression in isolated human PBMCs at 24 UG/ml; increases survival of mice infected with C. albicans or C. krusei at 1 mg/kg per day
Cayman Chemical Heptadecnoyl-L-carnItInch 10mg
A long-chain acylcarnitine; levels are increased in dried blood spots from neonates with propionic or methylmalonic acidemias
Cayman Chemical AM694 NpentnoIc ACD metao 10mg
An expected urinary metabolite of AM694, based on the known metabolism of similar compounds; intended for forensic and research applications
Cayman Chemical UAMC-3203hydrochlorIde 10mg
A ferroptosis inhibitor (IC50 = 10 nM for erastin-induced ferroptosis in IMR-32 cells); decreases iron-induced plasma LDH levels in a mouse model of acute iron poisoning at 20 µmol/kg; not toxic to mice at 20 µmol/kg for four weeks
Cayman Chemical SB-216641hydrochlorIde 10mg
A 5-HT1B receptor antagonist; binds to 5-HT1B receptors (Ki = 1 nM); selective for 5-HT1B over 5-HT1A, 5-HT1D, 5-HT1E, and 5-HT1F receptors in radioligand binding assays (Kis = 500, 25, >1,000, and >1,000 nM, respectively); reduces 5-HT-induced inhibition of forskolin-induced cAMP production in CHO cells expressing human 5-HT1B receptors from 1-1,000 nM
Cayman Chemical Glycyrhza uralens Lqurtn 10mg
A flavonoid with diverse biological activities; inhibits corticosterone-induced apoptosis in PC12 cells at 1 and 2 mg/ml; reduces spinal cord levels of IL-1β, IL-6, and TNF-α and alleviates mechanical and cold allodynia, as well as thermal hyperalgesia, in a mouse model of neuropathic pain induced by CCI of the sciatic nerve at 120 mg/kg; decreases the viability of SiHa, CaSki, and HeLa cervical cancer cells and inhibits migration and invasion of SiHa cells in vitro at 40, 60, and 80 μM; reduces tumor growth in a SiHa mouse xenograft model at 10, 20, and 30 mg/kg
Cayman Chemical LevocabastInhydrochlorIde 10mg
A histamine H1 receptor antagonist (Ki = 62.5 nM); selective for histamine H1 over H2 and H3 receptors (Kis = 23.5 and 1.94 µM, respectively); binds to the rat neurotensin-2 receptor (IC50 = 10 nM); reduces the severity of ovalbumin-induced conjunctivitis in ovalbumin-sensitized rats when applied ocularly to ovalbumin-sensitized rats
Cayman Chemical SKF 86466hydrochlorIde 10mg
An α2-AR antagonist (Kis = 9.4, 16, and 20 nM for α2A, α2B, and α2C receptors, respectively); selective for α2-ARs over α1-ARs (Kis = 449, 485, and 126 nM for α1A, α1B, and α1D receptors, respectively); inhibits contractions in rabbit aorta and canine saphenous vein induced by norepinephrine or B-HT 920, respectively (KBs = 600 and 42 nM, respectively); decreases diastolic blood pressure in DOCA-salt hypertensive, spontaneously hypertensive, and 2K-1C renal hypertensive rats at 2 mg/kg, i.v.; reduces reserpine-induced muscle rigidity in a mouse model of Parkinson's disease at 1 mg/kg
Cayman Chemical 20 R-ProtopnaxadIol 10mg
A sapogenin with anticancer and antibacterial activities; has cytotoxic activity in MT-4 cells (CC50 = 6.1 µM); inhibits the growth of A549, SKOV3, SK-Mel-2, P388, L121, and K562 cells (ED50s = 11-26 µM); inhibits the growth of H. pylori in vitro (MICs = 50-100 UG/ml)
Cayman Chemical DPPEfumarate 10mg
An AEBS ligand (Ki = 55.6 nM in rat liver microsomes); selective for the AEBS over the estrogen receptor at 10 µM; cytotoxic to S10 and MCF-7 cells (IC50s = 7.5 and 12 µM); inhibits antigen-induced histamine release in isolated rat mast cells (IC50 = 65-85 µM); decreases uterine size in immature oophorectomized rats; protects bone marrow progenitor cells from doxorubicin-induced cytotoxicity in mice at 4 mg/kg
Cayman Chemical ZatebradInhydrochlorIde 10mg
Blocks If currents through HCN channels in sinoatrial node cells (IC50s = 1.83, 2.21, 1.9, and 1.88 µM, respectively for HCN1-4 in vitro); reduces heart rate from 600 to 200 beats per minute with an ED50 value of 1.8 mg/kg and induces increasing arrhythmia at concentrations >10 mg/kg when assessed through telemetric ECG recording in mice
Cayman Chemical GYKI 52466hydrochlorIde 10mg
An allosteric AMPA receptor antagonist; selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also inhibits kainate-induced inward currents in the same cells (IC50 = 11 µM); reduces the amplitude of spontaneous EPSCs in the same cells at 10 µM; increases the latency to seizure onset and reduces mortality in a rat model of 4-AP-induced generalized tonic-clonic seizures at 25 and 50 mg/kg; prevents neuronal damage in the CA1 region of the hippocampus in a four-vessel occlusion-induced rat model of global ischemia-reperfusion injury at 30 mg/kg