Custom Peptides
Cayman Chemical ArachIdonyl GlycIn 10mg
Produced endogenously via oxidation of AEA, or by transacylation of arachidonoyl CoA; has analgesic activities in whole animal experiments, yet is a very poor ligand for the CB1 receptor
Cayman Chemical N3hydroxydecnoylLHomoser 10mg
A bacterial quorum-sensing signaling molecule; induces expression of tda, a gene with roles in the production of the antibiotic TDA and the algicide roseobacticide, in P. inhibens
Cayman Chemical ParecoxIbsodIum salt 10mg
A prodrug form of valdecoxib; converted to valdecoxib by human liver microsomes in vitro and in vivo in rats, dogs, and cynomolgous monkeys; a CB1 agonist (EC50 = 2.4 µM in HEK293 cells); reduces hyperalgesia in a rat model of carrageenan-induced foot pad edema (ED50 = 5 mg/kg) and decreases inflammation in a rat model of M. butyricum-induced arthritis (ED50 = 0.08 mg/kg)
Cayman Chemical HTMTmaleate 10mg
A histamine H1 receptor agonist; binds to the histamine H4 receptor (Ki = 1.2 µM) but does not increase calcium mobilization in HEK293 cells expressing the receptor at 10 µM; increases intracellular calcium and inositol phosphate levels (EC50s = 19 and 30 µM, respectively) in human peripheral blood lymphocytes; increases proliferation of immortalized mouse small, but not large, cholangiocytes, at 10 µM; increases levels of sheep red blood cell-induced IgG and IgM antibodies in rabbit serum at 10 UG/kg twice per day; induces scratching in mice at an intradermal dose of 0.2 µmol, an effect that is reduced by the H1 receptor antagonist terfenadine
Cayman Chemical PPACKhydrochlorIde 10mg
A synthetic peptide derivative that irreversibly and specifically inhibits thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki = 0.24 nM); used as an anticoagulant (100 μM)
Cayman Chemical Cudetaxestat 10mg
An autotaxin inhibitor (IC50 = ≤0.5 µM); reduces MDA-MB-435 cell migration (IC50 = 15 nM); reduces blood glucose levels in a glucose tolerance test, as well as baseline blood glucose levels, in mice fed a high-fat diet at 15 mg/kg twice per day for two days; reduces liver fibrosis in a CDAA/HFD mouse model of liver fibrosis at 10 mg/kg; reduces colon ulcer area and increases colon length in mouse models of acute and chronic ulcerative colitis, respectively
Cayman Chemical Mastoparn XtrIfluoroACTAt 10mg
An antimicrobial peptide; active against several Gram-positive and Gram-negative bacteria (MICs = 3-64 and 4-256 UG/ml, respectively) and induces permeabilization of E. coli cytoplasmic membranes by 86% at 6.4 UG/ml; induces GDP/GTP exchange by Gi and binds to calmodulin (Kd = ~0.9 nM) in cell-free assays; induces necrosis in T98G cells at 20 µM; induces degranulation of isolated rat peritoneal mast cells at 128 UG/ml; induces hemolysis of isolated sheep, chicken, and human erythrocytes; increases survival, decreases disease severity, and prevents damage to jejunal villi and crypts in a mouse model of enterohemorrhagic E. coli infection at 20 mg/kg
Cayman Chemical TRAP6 amIdetrIfluoroACTAt 10mg
A peptide PAR1 agonist; induces platelet aggregation in vitro (EC50 = 0.15 µM); induces relaxation of isolated guinea pig internal anal sphincter strips at 30 µM; increases cigarette smoke extract-induced IL-8 release from isolated human bronchial epithelial cells at 50 µM
Cayman Chemical 2 4DImethylethcathInonhyd 10mg
A disubstituted analog of ethcathinone; intended for forensic and research purposes
Cayman Chemical NaphthofluoresceIn 10mg
A cell-permeable inhibitor of furin (IC50 = 12 μM); inhibits furin-mediated cleavage of the pro-form of MT1-MMP, resulting in decreased levels of active MT1-MMP; inhibits the invasion of Matrigel by the human fibrosarcoma cell lines HT1080
Cayman Chemical DOTA-NOCacetate 10mg
A synthetic peptide; has been conjugated to radioligands for use in PET imaging of neuroendocrine tumors and for tissue distribution studies in vivo
Cayman Chemical PentostatIn 10mg
A purine antimetabolite and an ADA inhibitor (Ki = 0.09 nM); reduces 2'-deoxyadenosine-induced growth inhibition of MOLT-4 lymphoblast cells (Ki = 5.6 µM); inhibits erythrocytes and ascites tumor cell ADA in an L1210 murine lymphocytic leukemia model at 0.2 mg/kg; inhibits tumor growth and increases survival rate in a CT26/NY-ESO-1 mouse xenograft model at 10 UG/mouse
Cayman Chemical 6-SIalylactosesodIum salt 10mg
A major milk oligosaccharides that avidly bind several viral strains, including strains of influenza, HIV-1, reovirus, and polyomavirus; used to differentiate and characterize the binding domains of viruses that recognize N-acetylneuraminic acid-capped cell surface receptors; also used as an analytical reference standard for quantification in samples such as milk or colostrum
Cayman Chemical ChlorthalIdon 10mg
A non-thiazide diuretic; inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney; inhibits carbonic anhydrase isoforms CAVB, VII, IX, XII, and XIII (Kis = 2.8-23 nM) and, to a lesser extent, CAI, CAII, IV, VA, and VI (Kis = 138-1,347 nM); reduces arterial hypertension and prevents or reduces ventricular hypertrophy in DOCA-salt hypertensive rats
Cayman Chemical EmpaglIflozIn 10mg
An SGLT2 inhibitor (IC50 = 3.1 nM for the human transporter); reduces non-fasting blood glucose levels, as well as aortic superoxide levels and cardiac interstitial fibrosis, in db/db mice when administered in the diet at 0.03%; decreases the severity of glomerulosclerosis, as well as reduces the escape latency in the Morris water maze, in the same model