Custom Peptides
Cayman Chemical HIstatIn 3trIfluoroacetAT 10mg
An antimicrobial peptide; active against C. albicans (LC50 = 9.2 µM); induces actin polymerization in a cell-free assay at 12 µM
Cayman Chemical P4pal10trIfluoROCTAte sal 10mg
A PAR4 and FPR2 antagonist and an FFAR2 agonist; selectively inhibits the aggregation of isolated human platelets induced by AYPGKF-NH2 (IC50 = 0.5-1 µM) over SFLLRN-NH2, U-46619, ristocetin, ADP, or collagen at 5 µM; inhibits WKYMVm- but not fMLF-induced increases in intracellular calcium in isolated human neutrophils; induces superoxide production in TNF-α primed Cmp58-stimulated isolated human neutrophils; reduces myocardial infarct size in a rat model of coronary artery ligation-induced ischemia-reperfusion injury at 1, 3, or 10 UG/kg; increases the paw withdrawal threshold in rat models of osteoarthritis induced by monoiodoacetate injection into the knee joint or medial meniscal transection
Cayman Chemical ErIodIctyol 7-O-glucosIde 10mg
A flavanone glucoside; scavenges hydroxyl and superoxide anion radicals in cell-free assays (IC50s = 0.28 and 0.3 mM, respectively); activates Nrf2 in a reporter assay; protects against cisplatin-induced cytotoxicity in HRMCs, but not A549 or MDA-MB-231 cells, at 80 µM; attenuates neurological deficits and reduces infarct volume in a rat model of MCAO-induced cerebral ischemia at 30 mg/kg
ABclonal Technology Phospho-IRAK4-Thr345/Ser346 Rabbit pAb
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Cayman Chemical ParaxnthIn 10mg
An active metabolite of caffeine; an adenosine A1 and A2 receptor antagonist (Kis = 35 and 22 µM, respectively); increases striatal cGMP and extracellular striatal dopamine levels and locomotor activity, as well as inhibits motor depression induced by CPA or CGS 21680 in rats not habituated to caffeine at 30 mg/kg; promotes wakefulness and increases locomotor activity and core temperature in narcoleptic transgenic mice without increasing behavioral anxiety
Cayman Chemical -ClopIdogrelhydrochlorId 10mg
A racemic mixture of (R)-(–)-clopidogrel and (S)-(+)-clopidogrel
Cayman Chemical EpIrubIcInhydrochlorIde 10mg
A stereoisomer of the antitumor anthracycline doxorubicin that undergoes β-glucuronidation, which partially detoxifies the dose-limiting side effects that are present with doxorubicin; equally cytotoxic to HeLa cells compared to doxorubicin (ID50s = 9 μM)
Cayman Chemical TG11-77hydrochlorIde 10mg
An EP2 receptor antagonist (KB = 9.7 nM); selective for EP2 over DP1, EP4, and IP receptors (KBs = 7,320, 5,300, and >10,000 nM, respectively); inhibits the expression of genes encoding COX-2, IL-1β, and IL-6 induced by LPS and the EP2 receptor agonist ONO-AE1-259-01 in mouse BV-2 microglia expressing human EP2 receptors at 0.3 and 1 μM
Cayman Chemical MethylophIopogonon B 10mg
An isoflavone; increases Rho activity in NHEMs at 1 µM; inhibits LPS-induced NO production in BV-2 microglia (IC50 = 7.8 µM); reduces hydrogen peroxide-induced production of ROS, apoptosis, and decreases in SOD activity in HUVECs at 40 and 50 µM; cytotoxic to SMMC-7721 and HeLa cancer cells (IC50s = 34.6 and 6 UG/ml, respectively)
Cayman Chemical VerdIperstat 10mg
An irreversible inhibitor of MPO (IC50 = 630 nM); selective for MPO over a panel of 130 enzymes, transporters, and ion channels (IC50s = >50 µM for all); reduces MPO expression, prevents an increase in neuronal loss, and prevents decreases in motor score and stride length in a PLP-αSYN transgenic mouse model of multiple system atrophy at 180 µmol/kg, p.o.
Cayman Chemical SynthetIc HIspIdol 10mg
An aurone with diverse biological activities; is an inhibitor of tyrosinase, MAO-A, and MAO-B (IC50s = 38.4, 0.26, and 2.45 µM); increases catalase and SOD activity in cell-free assays, as well as decreases intracellular ROS in, and increases the lifespan of, C. elegans at 50 µM; decreases immobility time in forced swim and tail suspension tests in mice at 2, 5, and 15 mg/kg
Cayman Chemical DelgocItInIb 10mg
An inhibitor of JAK1, JAK2, JAK3, and TYK2 (IC50s = 2.8, 2.6, 13, and 58 nM, respectively); is selective for JAK1, JAK2, JAK3, and TYK2 over LCK (IC50 = 5,800 nM); inhibits IL-31-induced increases in STAT3 phosphorylation levels in A549 cells (IC50 = 25 nM); reduces IL-31-induced scratching in mice in a dose-dependent manner