Custom Peptides
Cayman Chemical PropentofylIn 10mg
A phenylethanoid with diverse biological activities scavenges DPPH radicals in a cell-free assay (IC50 11 8 UM) inhibits 5- and 15-LO (IC50s 0 375 and 96 UM respectively) decreases viability of TE-1 ESCC cells at 20-320 Ug/ml as well as inhibits LPS-induced EMT in Eca-109 and TE-1 cells and decreases phosphorylated NF-KB levels in TE-1 cells inhibits arachidonic acid-induced mouse ear edema at 3 mg/ear
Cayman Chemical OnjIsaponIn B 10mg
A bacterial siderophore has been used as a growth enriching agent in the detection of Salmonella in food and industrial applications
Cayman Chemical HexnoIc AcId-d5 10mg
An internal standard for the quantification of difloxacin by GC- or LC-MS
Cayman Chemical ItoprIdehydrochlorIde 10mg
An internal standard for the quantification of hexanoic acid by GC- or LC-MS
Cayman Chemical mK1trIfluoroacetate salt 10mg
A prenylated flavonoid with diverse biological activities inhibits UGT1A6 UGT1A7 and UGT1A8 (IC50s 4 23 0 98 and 3 M respectively) inhibits CYP3A4 CYP1A2 CYP2C9 and CYP2E1 (IC50s 2 13 1 27 3 18 and 9 28 M respectively) inhibits A23187- and PMA-induced histamine and LTC4 production in mouse MC/9 mast cells at 4 M inhibits the growth of MCF-7 MDA MB 231 and MDA MB 453 breast cancer cells (IC50s 13 53 10 84 and 11 99 M respectively) decreases colonic tissue damage TGF-B1 levels and MMP-2 and MMP-9 activity in a rat model of TNBS-induced ulcerative colitis at 12 5 mg/kg per day
Cayman Chemical EchInacosIde 10mg
A peptide agonist of PAR1 activates p42/44 MAPK signaling in fibroblasts expressing PAR1
Cayman Chemical 2AmIno3 4dImethyl3HImIda 10mg
A diterpene with diverse biological activities cytotoxic to a variety of prostate colon and breast cancer cells (IC50s 15 03-48 87 g/ml) active against S epidermidis S capitis E faecalis and S haemolyticus in vitro (MICs 6 25-12 5 g/ml) reduces colonic MPO activity and MDA levels in a rat model of acetic acid-induced colitis at 50 and 100 mg/kg as well as colonic tissue damage leukocytic infiltration and submucosal edema when administered at a dose of 100 mg/kg
Cayman Chemical Sartrypyron B 10mg
A racemic mixture of ( )-N-3-benzylnirvanol and ( )-N-3-benzylnirvanol lowers plasma levels of cholesterol in mice
Cayman Chemical BelvarafenIb 10mg
An ER proteostasis regulator activates an ATF6-dependent ER stress response element reporter and antioxidant response element reporter in HT22 hippocampal cells (EC50s 3 6 and 3 92 UM respectively) and protects against glutamate-induced cytotoxicity and prevents increases in ROS in HT22 cells at 10 UM reduces tunicamycin-induced cell death and increases ERAD in neonatal rat ventricular myocytes at 10 UM reduces the myocardial renal and cerebral infarct size as a percentage of the area at risk in mouse models of ischemia-reperfusion injury induced by LAD ligation renal portal system occlusion or MCAO respectively at 2 mg/kg prevents the production of NS5 in dengue virus-infected Huh7 cells (IC50 1 UM)
Cayman Chemical Apararenon 10mg
A fluorogenic substrate forBhexosaminidases is cleaved byBhexosaminidases to release the fluorescent moiety 4-U ex 320 and 360 nm at low (1 97-6 72) and high pH (7 12-10 3) respectively em 445 to 455 nm increasing as pH decreases has been used to quantifyBhexosaminidase activity in serum or leukocytes from patients with GM2 gangliosidoses such as Tay-Sachs disease
Cayman Chemical 15hydroxy PentadecNIc ACD 10mg
An antibody-drug conjugate containing the maytansinoid DM1 and the crosslinker SMCC
Cayman Chemical LIraglutIdeacetate 10mg
A substituted anilide whose physiological and toxicological properties are not known
Cayman Chemical Endosulfn II 10mg
A potent inhibitor of Cdk1 Cdk2 and Cdk9 (IC50s 16 6 and 20 nM respectively) inhibits kinase activity of Cdk5/p25 and GSK3B induces cell cycle arrest by inhibiting phosphorylation of CDK-dependent substrates has in vivo antiproliferative activity against a range of tumor cell lines (IC50s ranging from 200-1700 nM) in vivo oral administration inhibits growth of human tumor xenografts and inhibits cell cycle proteins
Cayman Chemical LIgustroflavon 10mg
A small molecule agonist of GHS-R1a (Ki 0 7 nM) induces calcium mobilization in CHO cells expressing rat GHS-R1a in a concentration-dependent manner and GH release from rat pituitary cells (EC50 1 5 nM) stimulates GH release in sham and vagotomized rats increases food intake in rats