Custom Peptides
Cayman Chemical CP 31 398hydrochlorIde 10mg
A p53 stabilizing agent; increases active mutant p53 and p53 reporter gene expression without increasing total protein levels of p53 in H1299 lung cancer cells transfected with mutant p53; is cytotoxic to a panel of 12 human glioma cell lines expressing wild-type or mutant p53 (EC50s = 11.2-22.2 μM); decreases tumor growth in an A375.S2 melanoma mouse xenograft model and completely inhibits tumor growth in a DLD-1 colon cancer mouse xenograft model at 100 mg/kg; dietary administration suppresses lung adenocarcinoma formation in a mouse model of tobacco carcinogen-induced lung adenoma and adenocarcinoma formation at 50 and 100 ppm
Cayman Chemical FondaparInuxsodIum salt 10mg
An inhibitor of Factor Xa (IC50s = 40, 45, and 36 nM for human, rabbit, and rat enzymes, respectively); binds to antithrombin III (Kds = 48, 132, 78, and 50 nM for human, rabbit, baboon, and rat, respectively); inhibits thrombin generation through the extrinsic and intrinsic routes (IC50s = 0.3 and 2.8 µM, respectively); dose-dependently inhibits thrombus formation in a rabbit model of venous thrombosis with complete inhibition of clot formation at a dose of 200 UG/kg
Cayman Chemical PSB-1115potasIum salt 10mg
An adenosine A2B receptor antagonist (Ki = 53.4 nM); selective for A2B over A1 and A2A receptors, which have Ki values of 2,200 and 24,000 nM, respectively; selective for A2B over the A3 receptor, which is inhibited only 14% at a concentration of 10 µM; pre-treatment of rat trachea reduces relaxation induced by repeated dosing of the non-selective adenosine agonist NECA
Cayman Chemical 1PalmItoyl2Oleoylsnglyce 10mg
A phospholipid; a major component of E. coli bilayers; vesicles composed of 1,2,-POPE can be disrupted by polycationic antimicrobials; has been used in combination with other lipids in the formation of LNPs for spleen- and liver-specific targeting in mice
Cayman Chemical M8-BhydrochlorIde 10mg
A selective antagonist of TRPM8 that blocks activation by cold, icilin, or menthol in vitro (IC50s = 7.8, 26.9, and 64.3 nM, respectively); decreases deep body temperature in wild-type mice and rats but has no effect on body temperature in TRPM8 knockout mice
Cayman Chemical SLM6031434hydrochlorIde 10mg
An SPHK2 inhibitor (Ki = 0.4 μM for the recombinant mouse enzyme); selective for SPHK2 over SPHK1 (Kis = >20 μM); decreases S1P and increases sphingosine levels in U937 monocytic leukemia cells in a concentration-dependent manner; reduces blood S1P levels in Sphk1-/-, but not Sphk2-/-, mice at 5 mg/kg; increases blood S1P levels in wild-type mice and rats
Cayman Chemical MIlnacIprnhydrochlorIde 10mg
A serotonin and norepinephrine reuptake inhibitor; selectively inhibits the human serotonin transporter and norepinephrine transporter over the dopamine transporter (IC50s = 420, 77, and 6,100 nM, respectively); inhibits sodium-dependent serotonin and norepinephrine uptake over dopamine uptake in rat cerebral cortical synaptosomes (IC50s = 28.0, 29.6, and >10,000 nM, respectively); is an antagonist of the 5-HT3A and nAChRs (IC50s = 63.5 and 14.3 μM, respectively); increases withdrawal threshold and latency in response to tactile and heat stimulation, respectively, in nerve-ligated mice (30 mg/kg)
Cayman Chemical ANTIBODYR-AS-1 10mg
A positive allosteric modulator of EAAT2 (EC50 = 11 nM in a glutamate uptake assay); selective for EAAT2 over EAAT1, EAAT3, and a panel of 30 other ion channels, transporters, receptors, and enzymes; increases spontaneous locomotor activity in mice at 60 and 90 mg/kg; has anticonvulsant activity in mouse models of seizures induced by MES, PTZ, or electrical stimuli of 32 or 44 mA (ED50s = 66.3, 36.3, 15.6, and 41.6 mg/kg, respectively)
Cayman Chemical DIsoglusIde 10mg
A steroidal saponin with diverse biological activities; inhibits UGT1A4 (IC50 = 10.5 µM); cytotoxic to K562 cells (IC50 = ~7.5 µM); improves neurological function and decreases neuronal damage in a rat model of spinal cord injury at 100 mg/kg; decreases serum levels of glucose, insulin, and triglycerides in diabetic db/db mice at 50 mg/kg; reduces serum MDA levels and stomach MPO activity in a mouse model of ethanol-induced gastric ulcers
Cayman Chemical 7 4-DI-O-methylapIgenIn 10mg
A flavonoid with diverse biological activities; inhibits MAO-B but not MAO-A (IC50s = 0.198 and >100 µM, respectively), as well as p38α MAPK but not JNK3 (IC50s = 27.8 and >100 µM, respectively); inhibits NO production in LPS-stimulated RAW 264.7 macrophages (IC50 = 24.5 µM); reduces the growth of C. albicans at 45 UG/ml; inhibits carrageenan-induced edema in rats (ED25 = 75 mg/kg)
Cayman Chemical NDSmethyltamoxIfenhydroch 10mg
An active metabolite of tamoxifen; inhibits PKC (IC50 = 8 µM for the rat enzyme); decreases iron (III) chloride and ascorbate-induced increases in TBARS in rat liver microsomes (IC50 = 17.5 µM); induces relaxation in isolated and washed rat aortic rings (pD2 = 9)
Cayman Chemical IndIMIII thIosemIcarbazon 10mg
An anticancer agent; cytotoxic to A549, MCF-7 breast, MCF-7/DDP cisplatin-resistant breast, and Hl 7702 liver cancer cells (IC50s = 2.41, 1.97, 2.11 µM, and 8.95 µM, respectively); decreases PI3K, Akt, mTOR, P-gp, and GSH levels in MCF-7/DDP cells; reduces tumor weight and volume in an MCF-7/DDP mouse xenograft model at 2.5 µmol/kg; liposomes containing it induce apoptosis and pro-death autophagy in MCF-7/DDP cells, as well as reduce tumor volume and weight in an MCF-7/DDP mouse xenograft model
Cayman Chemical 5 N NhexamethylenAmIlorI 10mg
An amiloride derivative with diverse biological activities; an allosteric antagonist of adenosine A2A receptors (Ki = 3.3 µM); inhibits the cation-selective ion channel formed by Vpu at 50 µM, as well as budding of virus-like particles in HeLa cells expressing the HIV-1 proteins Gag and Vpu at 10 µM; blocks the cation-selective ion channels formed by p7; induces necrosis in and reduces the viability of various breast cancer cells at 40 µM; protects against post-ischemic contractile dysfunction and reduces coronary effluent creatine phosphokinase activity in a model of ischemia-reperfusion injury using isolated rat right ventricular free walls
Cayman Chemical Acontum carmchal Dlsoln 10mg
A diterpene alkaloid with diverse biological activities; inhibits binding of α-bungarotoxin to rat neuronal α7 nAChRs (IC50 = 19 µM); repellent against adult red flour beetles in a filter paper assay at 3 mg/ml; lowers systolic blood pressure in a rat model of left renal artery ligation-induced hypertension at 75 mg/kg