Custom Peptides
Cayman Chemical 1 2 3TrIundecnoyl GlycRol 10mg
A triacylglycerol; dietary administration prevents fasting-induced decreases in plasma glucose, alanine, and insulin levels, as well as the ratio of insulin to glucagon, in rats
Cayman Chemical CenIcrIvIroc 10mg
An orally bioavailable antagonist of CCR5 and CCR2 (IC50s = 2.3 and 5.9 nM, respectively, for receptors in CHO cells); an antagonist of CCR3 and CCR4 (IC50s = 2.4 and 1.1 μM, respectively); completely inhibits replication of R5 HIV-1 in U87.CD4.CCR5 cells (100 nM); inhibits replication of the R5 HIV-1 strains JR-FL and KK in PBMCs (EC50s = 21-210 pM and 33-91 pM, respectively); reduces collagen deposition, levels of collagen type 1 protein and mRNA expression, and non-alcoholic fatty liver disease activity score in a mouse model of NASH (20 mg/kg per day); reduces collagen type 1 protein levels, mRNA expression, and collagen deposition in a mouse model of unilateral ureter obstruction and a rat model of thioacetamide-induced liver fibrosis
Cayman Chemical R 715trIfluoroacetAT salt 10mg
A bradykinin B1 receptor antagonist; inhibits bradykinin-induced contractions in isolated human umbilical cords, which express bradykinin B1 receptors (pA2 = 8.49); decreases the latency to tail withdrawal in the tail-flick test in an STZ-induced mouse model of diabetic neuropathy at 200, 400, and 600 UG/kg; reduces the incidence of hind limb weakness and paralysis, improves symmetrical gait, as well as decreases spinal inflammatory foci numbers, neuron demyelination, and lesion monocyte invasion, in a MOG35-55 peptide-induced mouse model of EAE at 1 mg/kg per day; reduces mean arterial blood pressure and increases heart rate in spontaneously hypertensive rats at 0.01 nmol/animal, i.c.v
Cayman Chemical 3 5-DIcaffeoylquInIc AcId 10mg
A natural phenolic compound that has antioxidant, anti-inflammatory, and antiviral biological activities; scavenges DPPH radicals in a cell-free assay (IC50 = 71.8 μM); inhibits superoxide production in fMLF- and cytochalasin B-activated human neutrophils (IC50 = 1.92 μM); inhibits HIV-1 integrase 3’-end processing, strand transfer, and disintegration in a cell-free assay (IC50s = 0.33, 0.34, and 0.66 μg/ml, respectively); inhibits HIV-1-induced cytotoxicity in MT-2 cells (ED50 = 1 μg/ml); protects mice from LPS-induced acute lung injury and decreases neutrophil count in BALF at 25 mg/kg
Cayman Chemical AldoxorubIcInhydrochLRIde 10mg
A prodrug form of doxorubicin; selectively binds to serum albumin, which releases doxorubicin in acidic environments, such as the tumor microenvironment; inhibits the proliferation of RenCa, MCF-7, and LXFL 529 cells (IC50s = 1, 1.1, and 0.5 µM, respectively); induces tumor regression in an MDA-MB-435 breast cancer mouse xenograft model at 39.3 µmol/kg; not toxic to mice unlike doxorubicin (LD50 = >60 mg/kg); has been used to conjugate doxorubicin to antibodies
Cayman Chemical SomatostatIn-14humnmouse 10mg
A cyclic peptide hormone; SST receptor agonist (IC50s = 0.22, 0.10, 0.28, 1.23, and 0.30 nM, respectively, in CCL39 cells expressing human recombinant SST1-5); inhibits forskolin-induced cAMP accumulation in CCL39 cells expressing human recombinant SST1-5 (EC50s = 6.16, 4.37, 17.38, 2.95, and 4.67 nM, respectively); inhibits the release of growth hormone, prolactin, thyrotropin, glucagon, and insulin, as well as other signaling molecules
Cayman Chemical 17trIfluoromthylphnyl13 1 10mg
A number of 17-phenyl trinor PGF2α derivatives have been approved for the treatment of glaucoma.{8941,9341,8839} Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.{9736} 17-trifluoromethylphenyl-13,14-dihydro trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl-13,14-dihydro trinor PGF2α would act very much like the free acid of latanoprost.
Cayman Chemical 13 14dIhdro15keto Prostag 10mg
Prominent plasma metabolite of PGF2α in the 15-hydroxy PGDH pathway
Cayman Chemical GSK121trIfluoROCTAte salt 10mg
The initial compound identified in a screen for PAD4 inhibitors (IC50 = 3.2 µM in functional assay) that was optimized to produce the more potent PAD4 inhibitors, GSK484 and GSK199
Cayman Chemical MInoxIdIl-d10 10mg
An internal standard for the quantification of minoxidil by GC- or LC-MS
Cayman Chemical aContoxIn ImItrIfluoroace 10mg
A conotoxin and an antagonist of α7 nAChRs (IC50 = 220 nM); selective for α7 nAChRs over α2β2, α3β2, α4β2, α2β4, α3β4, α4β4, and α1β1γδ subunit-containing nAChRs at 5 µM but does inhibit homomeric α9 nAChRs (IC50 = 1,800 nM); administration of paclitaxel in micelles containing α-conotoxin ImI decreases tumor growth in an MCF-7 mouse xenograft model; intracerebroventricular administration of α-conotoxin ImI induces seizures in rats at 20 nmol/animal
Cayman Chemical 1-MSHhumnmouseratbo 10mg
A peptide hormone; selectively binds to MC1R and MC3R over MC4R and MC5R (Kis = 0.025, 0.063, >100, and >100 µM, respectively, in insect cells expressing the human receptors) but also binds to opioid receptors in rat brain tissue homogenates (IC50 = 5.9 µM); inhibits FMRF-amide-induced contractions in isolated M. edulis catch muscle at 10 µM; intracisternal administration increases the latency to tail flick in the tail-flick test and inhibits haloperidol-induced catalepsy in mice at 0.3 nmol/animal; inhibits LPS-induced nitric oxide (NO) release in mouse forebrain in vivo at 0.01 nmol/animal
Cayman Chemical PhytnIc AcId 10mg
Phytanic acid is a saturated 20-carbon branched-chain fatty acid which can only be derived from dietary sources. In cases of peroxisomal disorders, elevated levels of phytanic acid have been observed, and this is linked to diseases such as infantile phytanic acid storage disease and Refsum’s disease.{1912}
Cayman Chemical 1 4-PBITdIhydrobromIde 10mg
1,4-PBIT is a potent inhibitor of purified human iNOS and nNOS with Ki values of 7.4 and 16 nM, respectively, compared to a Ki of 360 nM for human eNOS.{1292} Its inhibition in whole cells is greatly diminished, presumably to poor membrane permeability.
Cayman Chemical ArachIdnyl CyclopropylaMD 10mg
A potent and selective CB1 receptor agonist (Kis = 2.2 and 715 nM for CB1 and CB2, respectively); induces hypothermia in mice with the same efficacy as AEA in spite of its much higher affinity for the CB1 receptor and thus is a possible substrate for FAAH