Custom Peptides
Cayman Chemical 1-MSHhumnmouseratbo 10mg
A peptide hormone; selectively binds to MC1R and MC3R over MC4R and MC5R (Kis = 0.025, 0.063, >100, and >100 µM, respectively, in insect cells expressing the human receptors) but also binds to opioid receptors in rat brain tissue homogenates (IC50 = 5.9 µM); inhibits FMRF-amide-induced contractions in isolated M. edulis catch muscle at 10 µM; intracisternal administration increases the latency to tail flick in the tail-flick test and inhibits haloperidol-induced catalepsy in mice at 0.3 nmol/animal; inhibits LPS-induced nitric oxide (NO) release in mouse forebrain in vivo at 0.01 nmol/animal
Cayman Chemical UmIfenovIrhydrochlorIde 10mg
A broad-spectrum antiviral agent; inhibits the replication of H5N1 influenza (IC50 = 30 UG/ml) and SARS-CoV-2 in vitro (IC50 = 3.537 µM); inhibits entry of HCV pseudoparticles in Huh7 cells (IC50 = 6 UG/ml); reduces the formation of influenza-induced lung lesions in ferrets at 45 mg/kg
Cayman Chemical 8 4bromophenyl1 3 5 7tet 10mg
An intermediate in the synthesis of BODIPY-containing dyes; has been used as a precursor in the synthesis of BODIPY-containing photosensitizer dyes with antibacterial activity
Cayman Chemical TuftsInhumntrIfluoroace 10mg
A phagocytosis-stimulating peptide; binds human PMN, human monocytes, and mouse macrophages (Kds = 130, 125, and 53 nM, respectively); increases phagocytosis of IgG-coated ovine red blood cells by 61% in isolated mouse peritoneal macrophages at 200 nM; increases phagocytosis of S. aureus, L. monocytogenes, and S. oviformis by isolated human, mouse, rabbit, dog, or guinea pig phagocytes from 0.01-0.15 UG/ml; increases survival in a syngeneic mouse model of 2-methylcholanthrene-induced fibrosarcoma at 0.1, 0.5, and 25 mg/kg
Cayman Chemical ChenodeoxycholylputrescIn 10mg
A polyamine bile amidate; has been found in lion, but not mouse, fecal samples; has been used as a standard in the detection of chenodeoxycholyl-putrescine in mammalian intestinal and fecal samples
Cayman Chemical Q1-SM-102IodIde 10mg
A cationic quaternary ammonium lipid derivative of SM-102; LNPs containing Q1-SM-102 and SM-102 as a CLP and encapsulating mRNA encoding a luciferase reporter induce luciferase expression in the lungs and spleen in mice
Cayman Chemical AmbenonIumchlorIde 10mg
An AChE inhibitor (IC50 = 0.7 nM); selective for AChE over BChE (IC50 = 6.82 µM); increases the secretion of APP in primary rat basal forebrain cells at 10 µM; induces repetitive firing of electrically stimulated gastrocnemius muscle in anesthetized cats at 5 UG/animal; inhibits tubocurarine- or decamethonium-induced paralysis in anesthetized cats at 3 UG/animal
Cayman Chemical TaspoglutIdeacetate 10mg
An agonist of GLP-1R (Ki = 1.1 nM for the human receptor); induces cAMP accumulation in CHO-K1 cells expressing human GLP-1R (EC50 = 0.06 nM); decreases blood levels of glucose and increases blood levels of insulin in an oral glucose tolerance test in Zucker diabetic obese rats at 1 mg/animal per week; reduces blood levels of GIP, plasma levels of triglycerides, and body weight in the same model
Cayman Chemical SenTraGorCel Senscence Re 10mg
A PKM inhibitor (Ki 0 076-2 11 UM) inhibits PKCa at 10 UM prevents ionomycin-induced PKC translocation to the plasma membrane in HEK293 cells expressing AKAP79 at 5 UM inhibits the conditioned place preference response to morphine in rats when administered intracranially into the nucleus accumbens core at doses of 10 and 30 nmol/0 5 Ul per side
Cayman Chemical PaederosIdIc AcId 10mg
An iridoid glycoside; inhibits the proliferation of NCI H1650, HCC827, and A549 cells (IC50s = 40.68, 42.58, and 36.48 UG/ml, respectively); protects against PTZ- or maximal electroshock-induced seizures in mice from 10-40 mg/kg; increases duration of pentobarbital-induced sleep and decreases the latency to sleep onset in mice
Cayman Chemical FlutIcason Furoate 10mg
A synthetic glucocorticoid; selective for the glucocorticoid receptor over the mineralocorticoid, progesterone, and androgen receptors in reporter assays (EC50s = 0.03, 23.4, 0.9, and >10,000 nM, respectively), as well as ERα and ERβ in scintillation proximity assays (EC50s = >10,000 nM); reduces LPS-induced increases in TNF-α production in human PBMCs (EC50 = 0.12 nM); decreases S. aureus enterotoxin-induced increases in IFN-γ, IL-2, IL-5, IL-17, and TNF-α levels in patient-derived nasal polyp tissue in vitro at 100 nM; reduces ovalbumin-induced increases in BALF eosinophil infiltration in a rat model of allergic inflammation at 30 UG/animal intrathecally
Cayman Chemical 1 3BenzodIoxole5 6dIamIn 10mg
A fluorescent derivatization reagent; has been commonly used for the derivatization of α-keto, neuraminic, and sialic acids for detection by fluorometric HPLC
Cayman Chemical Ravuconazole 10mg
An orally available azole fungicide that potently inhibits the growth of a wide range of fungi (MICs range from 25 to 780 ng/ml); inhibits CYP isoforms that are involved in ergosterol biosynthesis, interfering with the generation of the fungal and protozoan cell membranes
Cayman Chemical FluphenazInN2chLRoethn 10mg
A derivative of fluphenazine that contains an alkylating chlorethylamine chain, which produces irreversible protein binding; a relatively selective, irreversible antagonist of D2 receptors both in vitro (IC50 = 100 nM) and in vivo; irreversibly inhibits calmodulin at higher doses (IC50 = 10 µM)
Cayman Chemical 5-trns ProstaglndIn F2atr 10mg
5-trans PGF2α tromethamine salt is a derivative of 5-trans PGF2α with increased water solubility. Its solubility in PBS is 25 mg/ml compared to 10 mg/ml for 5-trans PGF2α.