Custom Peptides
Cayman Chemical BrIncIdofovIr 10mg
A prodrug form of cidofovir; inhibits CMV, HSV-1, HSV-2, cowpox, and vaccinia virus replication in plaque reduction assays (EC50s = 0.0009, 0.06, 0.08, 0.6, and ~1 µM, respectively); decreases mortality in mouse models of cowpox or vaccinia virus infections at 6.7 or 5 mg/kg, respectively
Cayman Chemical ngIotensIn AtrIfluoroACTA 10mg
An AT1 and AT2 receptor agonist and active metabolite of angiotensin II; binds to AT1 and AT2 receptors in HEK293 cells expressing the rat receptors (IC50s = 0.29 and 0.12 nM, respectively, in radioligand binding assays); induces calcium mobilization in VSMCs (EC50 = 100 nM); increases the perfusion pressure in isolated perfused rat kidney (EC50 = 443 nM), an effect that can be reversed by EXP-3174; the plasma Ang A/Ang II ratio is increased in patients with end-stage renal failure; serum levels are decreased in patients with pulmonary arterial hypertension
Cayman Chemical 4 7-DI-O-methylnarngenIn 10mg
A flavonoid aglycone; inhibits the Kv1.3 channel in a patch-clamp assay at 30 µM; cytotoxic to human LNCaP prostate, Lu1 lung, and MCF-7 breast cancer cells (EC50s = 6.7, 4.7, and 1.1 µM, respectively)
Cayman Chemical N6 6AmInohexylcarbamoylme 10mg
An alkylated ADP derivative; has been biotinylated and conjugated to an azidonitrobenzoyl group for use as a photoaffinity probe to visualize the ATPase site of rabbit myosin
Cayman Chemical 11-Hydroxyprogesteron 10mg
A metabolite of progesterone; an MR agonist (EC50 = 0.05 µM in a reporter assay); an inhibitor of 11β-HSD2 and 11β-HSD1 (IC50s = 0.140 and 1 µM, respectively); increases blood pressure in rats at 10 UG/hour; serum levels are increased in patients with 21-hydroxylase deficiency
Cayman Chemical AmInoacetonhydrochlorIde 10mg
A threonine and glycine catabolite that can be converted to methylglyoxal by amine oxidases; at 0.10-5 mM acts as a pro-oxidant inducing cell death in RINm5f pancreatic β-cells; used as a growth substrate for Pseudomonas
Cayman Chemical ResmInostathydrochlorIde 10mg
An orally bioavailable inhibitor of HDAC1, HDAC3, and HDAC6 (IC50s = 43-72 nM), resulting in hyperacetylation of histone H4 in multiple myeloma cells; abrogates cell growth and strongly induces apoptosis in multiple myeloma cells (IC50s = 2.5-3 µM); dose-dependently inhibits HDAC activity in vivo
Cayman Chemical IBTPIodIde 10mg
A lipophilic cation that is accumulated in mitochondria and forms stable thioether adducts in a thiol-specific manner
Cayman Chemical RBI 257maleate 10mg
A potent dopamine D4 receptor antagonist (Ki = 0.3 nM) that is selective over D2L, D3, D2-like, and D1 receptors by 1,721-, 439-, 1,336-, and 8,576-fold, respectively.{28464}
Cayman Chemical Galantamine 10mg
An alkaloid with AChE inhibitory and nAChR potentiating activities; selectively inhibits AChE over BChE (IC50s = 636 and 8,404 nM, respectively); potentiates ACh-induced currents in HEK293 cells expressing human α4β2 subunit-containing nAChRs at 0.5 µM; decreases escape latency and path length in the Morris water maze in the APP23 transgenic mouse model of Alzheimer’s disease at 1.3 mg/kg per day
Cayman Chemical RoseoflavIn 10mg
A riboflavin analog that possesses antimicrobial activity; binds directly to FMN riboswitch aptamers (KD = ~100 nM), downregulating the expression of genes responsible for the synthesis and transport of riboflavin
Cayman Chemical Cysmethynil 10MG
An indole-based, time-dependent inhibitor of Icmt (IC50 = i = 0.14 µM for the final complex); decreases mTOR signaling, accumulation of cells in the G1 phase, and autophagy-mediated cell death in PC3 prostate cancer cells
Cayman Chemical RutaecarpIn 10mg
A quinazolinone alkaloid with diverse biological activities; inhibits COX-1 and COX-2 in BMMC cells (IC50s = 8.7 and 0.28 µM, respectively); selective for COX-2 in HEK293 cells (IC50s = >400 and 2.8 µM, for COX-1 and COX-2, respectively); slows cancer cell growth in vitro (GI50s = 8.41-31.6 µM); induces vasodilation (0.1-10 µM) in isolated rat aorta; decreases plasma levels of caffeine in rat through CYP1A2 and CYP2E1 metabolism induction at a dose of 80 mg/kg
Cayman Chemical DIoleyldImethylamonIMchlo 10mg
A cationic lipid; has been used as a transfection reagent; liposomes containing DODAC and DOPE and encapsulating a plasmid DNA reporter induce reporter gene expression in C2C12 mouse skeletal muscle myoblasts