Custom Peptides
Cayman Chemical Preladenant 10mg
An adenosine A2A receptor antagonist (Kis = 1.1 and 2.5 nM for human and rat receptors, respectively); selective for A2A receptors over A1, A2B, and A3 receptors, with Ki values greater than 1,000 nM, and a panel of receptors enzymes and ion channels; inhibits A2A receptor agonist-induced adenylate cyclase activity (Kbs = 1.3 and 0.7 nM for human and rat receptors, respectively); inhibits catalepsy induced by haloperidol in rats by 77 and 70% after 1 and 4 hours, respectively (1 mg/kg); increases the efficacy of L-DOPA when used in combination with eltoprazine
Cayman Chemical GambogenIc AcId 10mg
A xanthone with diverse biological activities; reduces the proliferation of HeLa and HEL cells (MICs = 12.5 and 3.13 UG/ml, respectively); reduces the proliferation of, and induces apoptosis in, HepG2 cells, as well as induces cell cycle arrest at the G0/G1 phase in, and decreases migration of, M14 cells, in a concentration-dependent manner; oral administration of LNPs encapsulating gambogenic acid reduces tumor volume and weight in a 4T1 murine mammary carcinoma model
Cayman Chemical 10 11dIhydro10 11dIhydrxy 10mg
A metabolite of carbamazepine and oxcarbazepine; has been found in wastewater effluent
Cayman Chemical UDPGlucuronIc AcIdodIum s 10mg
A source of glucuronic acid for polysaccharide biosynthesis; used for the formation of many glucuronides with various aglycones
Cayman Chemical ArIpIprazole 10mg
An atypical antipsychotic; a partial agonist at dopamine D2, D2L, and D3 receptors (Kis = 3.3, 0.74, 9.7 nM, respectively), a partial agonist of 5-HT1A receptors (Ki = 5.6 nM), and an inverse agonist of 5-HT2B receptors (Ki = 0.36 nM); inhibits disruptions in prepulse inhibition induced by phencyclidine in mice when administered at doses of 5 and 10 mg/kg
Cayman Chemical Dehydroergosterol 10mg
A fluorescent cholesterol analog (ex/em = 324/375 nm) useful as a probe in membrane research
Cayman Chemical 14-PentadecenoIc AcId 10mg
A 15-carbon, long-chain fatty acid that contains an alkene functional group on the terminal carbon of its aliphatic tail
Cayman Chemical DAMGOtrIfluoroacetAT salt 10mg
A selective peptide agonist of the µ-opioid receptor (Kis = 1.18, 1,430, and 213 nM for human µ-, δ-, and κ-opioid receptors, respectively)
Cayman Chemical DehydrolIthocholIc AcId 10mg
A major metabolite of lithocholic acid; formed from LCA by CYP3A4; an agonist of TGR5 (EC50 = 0.27 μM), VDR (EC50 = 3 μM), and FXR in cell-based reporter assays; binds to human PXR (IC50 = 15 μM) and activates mouse and human PXRs in cell-based reporter assays at 100 μM; binds to RORγt (Kd = 1.13 μM for the recombinant human ligand-binding domain) and decreases its activity in a cell-based reporter assay at 10 μM; inhibits the differentiation of TH17 cells at 20 μM
Cayman Chemical MesorIdazIn 10mg
An active metabolite of thioridazine; formed via sulfoxidation of thioridazine by CYP2D6 in human liver microsomes; binds to histamine H1, dopamine D2, muscarinic acetylcholine, and α1- and α2-adrenergic receptors (Kds = 1.8, 19, 69, 2, and 1,600 nM, respectively); prevents mescaline-induced hyperactivity in mice at 10, 30, and 45 mg/kg
Cayman Chemical PInocembrIn 10mg
A flavonoid with diverse biological activities; induces apoptosis in, and inhibits the migration of, SKOV3 ovarian cancer cells at 200 µM; reduces lesion volume, as well as brain microglial activation and production of IL-1β, IL-6, and TNF-α in a mouse model of collagenase-induced ICH at 5 mg/kg; prevents increases in plasma and kidney MDA levels, glomeruli lobulation, mesangial expansion, and tubule vacuolization and occlusion, and it decreases hepatic cholesterol, triglyceride, and LDL levels in a rat model of diabetic nephropathy; reduces pulmonary edema, as well as neutrophil, lymphocyte, and macrophage infiltration in a mouse model of LPS-induced lung injury at 20 and 50 mg/kg
Cayman Chemical SolIthromycIn 10mg
A macrolide antibiotic; active against Gram-positive and Gram-negative bacteria, including C. trachomatis and C. pneumoniae (MICs = 0.125-0.5 and 0.25-1 μg/ml, respectively); inhibits growth of multidrug resistant P. falciparum in vitro (IC50s = 0.5 nM for both Dd2 and 7G8 strains); eradicates P. berghei infection in mice when administered in a four-dose series at 100 mg/kg
Cayman Chemical GlycolIthocholIc AcId 10mg
A glycine-conjugated form of lithocholic acid; increased in the liver of mice fed a diet supplemented with ursodeoxycholic acid; decreased in the plasma by PEG-obestatin(Cys10, Cys13) in lean or diet-induced obese mice; serum levels increase with age in children
Cayman Chemical DolutegravIr 10mg
A potent inhibitor of HIV integrase (IC50 = 2.7 nM for HIV-1 integrase-catalyzed strand transfer in vitro); inhibits HIV-1 viral replication (EC50 = 0.51 nM) in PMBCs; CC50 values are 189 and 52 µM in unstimulated and stimulated PBMCs; prevents replication of several HIV-1 strains (EC50s = 0.36-2.1 nM) that are resistant to NRTIs, NNRTIs, and protease inhibitors and impairs their ability to infect CIP4 cells
Cayman Chemical Cyclo RGDfK 10mg
An inhibitor of αvβ3 integrin (IC50 = 1.33 nM); taken up into tumors in vivo and in vitro and it has been polymerized or conjugated to various fluorophores, radiolabels, and peptide sequences for use in fluorescent and PET imaging to study tumor cell adhesion