Custom Peptides
Cayman Chemical Meropenmhydrate 10mg
A carbapenem antibiotic; active against clinical isolates of Gram-positive and Gram-negative bacteria in vitro, including S. pneumoniae, H. influenzae, N. gonorrhoeae, E. coli, P. aeruginosa, C. difficile, and methicillin-susceptible and -resistant S. aureus (MICs = ≤0.008-8 μg/ml); protective against S. aureus, S. pneumoniae, E. coli, S. marcescens, P. mirabilis, and P. aeruginosa infections in mice (PD50s = 0.13, 0.01, 0.04, 0.07, 0.84, and 0.46 mg/kg, respectively)
Cayman Chemical BenIdIpInhydrochlorIde 10mg
An orally bioavailable inhibitor of L-, T-, and N-type calcium channels; IC50 = 2.7 nM in guinea pig ventricular cells; prevents oxidative stress in vitro and in neural stem cells; has antihypertensive effects; competitive antagonist at mineralocorticoid receptors
Cayman Chemical 71 1HTetrazolylACTAmIdo 10mg
A potential impurity in commercial preparations of cefazolin
Cayman Chemical 3 4dImethoxyaPyrroldInope 10mg
An analog of MDPV, differing only by an opening of the ring structure on the phenyl group; intended for research and forensic applications
Cayman Chemical 1 2 3TrIundecnoyl GlycRol 10mg
A triacylglycerol; dietary administration prevents fasting-induced decreases in plasma glucose, alanine, and insulin levels, as well as the ratio of insulin to glucagon, in rats
Cayman Chemical 2OAcetyl20hydroxyecdyson 10mg
An ecdysone steroid hormone; completely inhibits the growth of the bacteria S. aureus, E. coli, and P. vulgaris, as well as the fungi C. albicans, A. alternata, and F. solani at 10 UG/ml; increases aggregation of Aβ42, increases fibril formation by 60%, and decreases oligomer levels in cell-free assays at 50 µM; reduces Aβ42-induced cytotoxicity of SH-SY5Y cells at 5 and 10 µM
Cayman Chemical BTS-54-505hydrochlorIde 10mg
An active metabolite of sibutramine; inhibits norepinephrine, 5-HT, and dopamine uptake in rat cortical synaptosomes (IC50s = 0.066, 5.1, and 0.61 µM, respectively); prevents reserpine-induced ptosis in rats (ED50 = 3.7 mg/kg); decreases immobility in the Porsolt learned helplessness test in mice at 10 mg/kg; increases colonic temperature and decreases food intake in rats at 10 mg/kg
Cayman Chemical Telmsartn 10mg
A nonpeptide angiotensin II receptor antagonist which selectively and insurmountably inhibits the angiotensin II AT1 receptor subtype (Ki = 3.7 nM); a partial agonist of PPARγ, activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (EC50 = 4.5 μM); potently reduces blood pressure
Cayman Chemical Latnoprost ethyl amIde 10mg
Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity. Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 UG/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides.
Cayman Chemical BIalaphosodIum salt 10mg
A natural non-selective phytotoxin that is converted in vivo to the active agent phosphinothricin, which inhibits glutamine synthetase (Ki = 6.1 µM); used in the selection of transgenic plants that express the bar gene, usually under the control of a constitutively active viral promoter
Cayman Chemical DIbenzylfluoresceIn 10mg
A fluorogenic probe that acts as a substrate for specific cytochrome P450 (CYP) isoforms, including CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19); used to detect changes in CYP catalytic activity caused by drugs or disease
Cayman Chemical GamIthromycIn 10mg
An antibiotic; active against macrolide-resistant R. equi and S. zooepidemicus (MIC90s = 1 and 0.125 μg/ml, respectively); reduces the number of pneumonic lesions in a bovine M. haemolytica challenge model at a dose of 6 mg/kg
Cayman Chemical Agomelatn 10mg
A melatonin receptor agonist (Kis = 0.14 and 0.41 nM for MT1 and MT2, respectively) and 5-HT2B and 5-HT2C antagonist (Kis = 0.26 and 0.71 nM, respectively); inhibits the 5-HT2-mediated penile erection response in rats at 40 mg/kg; increases extracellular levels of noradrenaline and dopamine in the frontal cortex of freely moving rats at 20-80 mg/kg; reduces immobility time in the forced swim test and increases the amount of time spent in the open arms of the elevated plus maze in mice in a transgenic neuroendocrine model of depression at 10 mg/kg
Cayman Chemical 13 14epoxy FlupROSnl Isop 10mg
An impurity generated in the production of travoprost; a 4:96 diastereomeric mixture of epoxides