Custom Peptides
Cayman Chemical Notoptrygum ncsum Nodakn 10mg
A coumarin glucoside with diverse biological activity; reduces LPS-induced increases in TNF-α, IL-6, and IL-1β mRNA expression and protein levels and NK-κB activity and translocation in RAW 264.7 macrophages at 25-100 µM; prevents airway inflammation, hyper-responsiveness, and remodeling in a mouse model of ovalbumin-induced chronic asthma at 5, 10, and 20 mg/kg; decreases protein levels of IL-4, IL-5, IL-13, MMP-2, and MMP-9 in BALF; increases proliferation of neural progenitor cells in the dentate gyrus and improves learning and memory in the passive avoidance test in mice
Cayman Chemical PasIreotIdeaspartatetrIf 10mg
An SSTR agonist; binds selectively to human SST1, SST2, SST3, and SST5 over SST4 (IC50s = 9.3, 1, 1.5, 0.16, and >100 nM, respectively, for human recombinant receptors); dose-dependently inhibits GHRH-stimulated growth hormone release by primary rat anterior pituitary cells; inhibits ACTH secretion by some primary human corticotrope adenomas (10 nM); inhibits ACTH release and proliferation by mouse AtT20 pituitary corticotrope cells in vitro (10 nM); inhibits tumor growth of subcutaneously implanted AtT20 cells in vivo in nude mice (1.5 μg per day); decreases plasma ACTH concentrations and tumor size in dogs with ACTH-dependent Cushing’s disease (0.03 mg/kg)
Cayman Chemical PInaverIumbromIde 10mg
An L-type calcium channel inhibitor (IC50 = 1.5 µM in a patch-clamp assay using isolated rabbit jejunal smooth muscle cells); binds to CHO cells expressing the Cav1.2 α1C-a or α1C-b subunits (Kis = 1.5 and 2.92 µM, respectively); inhibits ACh- or potassium chloride-induced contractions in colonic circular muscle strips isolated from non-stressed or cold-restraint-stressed rats (IC50s = 0.91 and 1.66 µM for ACh, respectively, and 3.8 and 8.13 µM for potassium chloride, respectively) in a model of stress-induced smooth muscle contractility disorder; increases survival and decreases pulmonary neutrophil infiltration in a mouse model of LPS-induced septic shock from 1-10 mg/kg
Cayman Chemical LotIglIpronhydrochlorIde 10mg
A GLP-1R agonist; induces cAMP accumulation in cells expressing human GLP-1R (EC50 = 0.96 nM)
Cayman Chemical StearoylLcarnItInchLRId 10mg
A long-chain acylcarnitine; inhibits sodium-dependent [3H]carnitine uptake in HPCT cells by 52% at 500 μM; inhibits lecithin:cholesterol acyltransferase activity in rat, but not human, plasma at 500 μM/ml of plasma; levels are decreased in plasma of patients with chronic fatigue syndrome and increased in patients with end-stage renal disease
Cayman Chemical 5 7 3 4 5Pentamethoxyflav 10mg
A flavonoid with diverse biological activities; inhibits pancreatic lipase in a cell-free assay; reduces lipid accumulation in 3T3-L1 adipocytes; inhibits transactivation of Nrf2 in a reporter assay using HEK293T cells at 10, 25, or 50 µM; sensitizes cisplatin-resistant A549 NSCLC cells to cisplatin; inhibits LPS-induced NO production in RAW 264.7 macrophages and GES-1 cells; decreases blood glucose levels and renal fibrosis in a rat model of STZ-induced diabetes at 5 mg/kg
Cayman Chemical DIltIazem-d3hydrochlorIde 10mg
An internal standard for the quantification of diltiazem by GC- or LC-MS
Cayman Chemical -5-trns Cloprostenol Isop 10mg
A more lipid soluble form of (+)-5-trans cloprostenol
Cayman Chemical AMThydrochlorIde 10mg
AMT is a potent, relatively selective inhibitor of iNOS with a Ki of 4.2 nM in mouse macrophages. It inhibits other isoforms of NOS, but at higher concentrations; the IC50 values for rat nNOS and bovine eNOS are 34 and 150 nM, respectively.{1351}
Cayman Chemical SIN-1chlorIde 10mg
Active metabolite of molsidomine that acts as a potent vasorelaxant and inhibitor of platelet aggregation; produces both NO and superoxide to generate peroxynitrite under physiological conditions
Cayman Chemical Fraxinellone 10mg
A liminoid degradant; has antifeedant activity against, and inhibits development of, armyworm larvae when applied to fresh wheat leaves at 5, 10, or 20 mg/ml; reduces LPS-induced nuclear translocation of the NF-κB subunit p65, as well as inhibits LPS-induced production of NO and PGE2 in RAW 264.7 cells; reduces tumor growth in an A549 mouse xenograft model at 30 or 100 mg/kg
Cayman Chemical IsorhamntIn 3OnohesperIdo 10mg
A flavonoid glycoside with antioxidant and osteoclastogenic activities; inhibits XO and scavenges superoxide radicals in a cell-free assay (IC50s = 48.75 and 30 UG/ml, respectively); promotes RANKL-induced osteoclastogenesis of mouse bone marrow-derived macrophages
Cayman Chemical n1177trIfluoroacetAT salt 10mg
A dual peptide GCGR and GLP-1R agonist; induces cAMP production in BHK-21 cells expressing human GCGR or GLP-1R (EC50s = 1.83 and 0.92 pM, respectively); reduces body weight and cumulative food intake in a mouse model of diet-induced obesity from 3-5 nmol/kg; reduces body weight, hepatic fat accumulation and fibrosis, and plasma ALT levels in a mouse model of NASH induced by a high-fat, high-fructose, and high-cholesterol diet