Drug Discovery Research Screening Libraries
AdipoGen Resveratrol
Chemical. CAS 501-36-0. Formula C14H12O3. MW 228.2. Isolated from Polygonum cuspidatum. Potent phenolic antioxidant found in grapes and red wine. Eicosanoid synthesis and platelet aggregation inhibitor. Estrogen receptor agonist. Chemopreventive. Specific inhibitor of cyclooxygenase-1 COX-1. Anti-inflammatory. Ribonucleotide reductase and DNA synthesis. Arrests cell cycle at S/G2 phase. Anticancer and antiproliferative compound. Apoptosis inducer. Protein kinase D inhibitor. Does not inhibit PKC. Autophagy inducer. Potent SIRT1 sirtuin 1 activator. Neuroprotective. Adipogenesis inhibitor. PGC-1alpha activator. Sonic hedgehog Shh signaling pathway modulator. Gli1 mRNA expression inhibitor. Downregulates Gli transcriptional activity. Cardioprotective. Anti-diabetic. Senescence modulator. Extends lifespan. Inhibitor of NLRP3 inflammasome activation.
AdipoGen Capsaicin from Capsicum annuum
Chemical. CAS 404-86-4. Formula C18H27NO3. MW 305.41. Synthetic. Primary active component of the heat and pain-eliciting lipid-soluble fraction of Capsicum pepper. Acts as an agonist at the vanilloid receptor VR1 TRPV1 receptor, a ligand-gated non-selective cation channel. Capsaicin elicits a sensation of burning pain by activation of TRPV1 on small, non-myelinated polymodal C-type nociceptive nerve fibers. It has been shown to have antinociceptive, anti-inflammatory, anti-obesity, neuroprotective and anticancer effects.
AdipoGen SB204990
Chemical. CAS 154566-12-8. Formula C18H22Cl2O5. MW 389.3. Potent ATP citrate lyase ACLY inhibitor. ATP citrate lyase ACLY, a key enzyme for lipid synthesis, is frequently overexpressed or activated in cancer to promote lipid synthesis and tumor progression. Cell permeable prodrug form of SB201076. Hypolipidemic agent. Fatty acid synthesis and cholesterol synthesis inhibitor in a dose-dependent manner. Useful agent for immunometabolism research. Orally active in vivo. Shown to block fatty acid synthesis and cancer cell growth in pre-clinical studies.
AdipoGen -Etomoxir Na
Chemical. CAS 828934-41-4. Formula C15H18ClO4 . Na. MW 297.8 . 23.0. . Irreversible inhibitor of carnitine palmitoyltransferase-1 CPT-1a a mitochondrial enzyme involved in fatty acid beta-oxidation. CPR-1a on the outer face of the inner mitochondrial membrane, consequently prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria, essential for the production of ATP from fatty acid oxidation. Fatty acid beta-oxidation FAO inhibitor. By regulating fatty acid oxidation it has hypoketonaemic, hypocholesteraemic and hypolipogenic effect, and the potential to affect ketogenesis, cholesterol synthesis and gluconeogenesis. Useful agent for immunometabolism research. Anticancer, antiobesity and antidiabetes agent. Increases food intake and reduces hepatic ATP/ADP ratio.
AdipoGen 7DW8-5
Chemical. CAS 1056025-00-3. Formula C41H72FNO9. MW 742. . Glycolipid derivative of alpha-GalCer. Potent stimulator of invariant natural killer T iNKT cells 140-fold lower EC50 compared to alpha-GalCer. Specific ligand strongest binding affinity of the lipid-binding MHC class I-like protein CD1d in human and mouse NKT cells with. Show to induce secretion of key cytokines such as IFN-gamma and IL-12, and activate autologous dendritic cells, as well as binding to CD1d and the invariant T cell receptor invTCR. Potent vaccine adjuvant ~100 times stronger than alpha-GalCer that can harness and amplify the immunotherapeutic potential of NKT cells to treat certain microbial infections such as malaria and HIV. Potential immunotherapeutic to treat cancer, infectious diseases and autoimmune diseases.
Enzo Life Sciences SCREEN-WELL Ion Channel ligand library (1 Library)
The SCREEN-WELL Ion Channel Ligand Library contains 70 ion channel blockers and openers for use in characterizing and identifying ion channels in individual cells or tissue. Application: HTS. Use/Stability: Stable for at least one year from the date of receipt when stored at -80°C. Long Term Storage: -80°C
American Research Products Inc AMERICAN RESEARCH PRODUCTS INC
5000604254 ATG5/AUTOPHAGY PROTEIN 5 ELISA
![OBORO LABS INC CAS# 1007375-02-1. 5 g. OCOH3 Pincer Ligand, 99%. IUPAC Name: 2,2',2''-(1,1-Dimethylethylidene)tris[1,1'-biphenyl]-4,4'-diol](https://assets.fishersci.com/TFS-Assets/CCG/product-images/Oboro2.jpg-250.jpg)
OBORO LABS INC CAS# 1007375-02-1. 5 g. OCOH3 Pincer Ligand, 99%. IUPAC Name: 2,2',2''-(1,1-Dimethylethylidene)tris[1,1'-biphenyl]-4,4'-diol
CAS# 1007375-02-1. 5 g. OCOH3 Pincer Ligand, 99%. IUPAC Name: 2,2',2''-(1,1-Dimethylethylidene)tris[1,1'-biphenyl]-4,4'-diol
Enzo Life Sciences SCREEN-WELL Histaminergic ligand library (100µl/well)
The Histaminergic and Melatonin Ligands Plate contains 41 ligands including endogenous neurotransmitters, agonists, antagonists, and marketed drugs. The library is ideal for screening or identifying recombinant orphan G protein coupled receptors, target validation, secondary screening, assay development, and other pharmacological applications. The Histaminergic and Melatonin Ligands plate is 1 plate of the larger Neurotransmitter Library (BML-2810) which contains over 680 ligands. Long Term Storage: -80°C. Applications: HTS .
Enzo Life Sciences SCREEN-WELL Serotonergic ligand library (100µl/well)
The Serotonergic Ligands Plate contains 79 ligands including endogenous neurotransmitters, agonists, antagonists, and marketed drugs. The library is ideal for screening or identifying recombinant orphan G protein coupled receptors, target validation, secondary screening, assay development, and other pharmacological applications. The Serotonergic Ligands plate is 1 plate of the larger Neurotransmitter Library (BML-2810) which contains over 680 ligands. Long Term Storage: -80°C. Applications: HTS .
TA Instruments Wiley NIST Mass Spectrometer Library, Identification of Unknown Samples, Comparison to Known Material Ionization Cracking Patterns
Waters TA Instruments Wiley/NIST Mass Spectrometer Library is used for identification of unknown samples. The software compares the mass spectrometry ionization cracking pattern of unknown samples with those of known individual materials.