Drug Discovery Research Screening Libraries
AdipoGen Irisin recEcoliuntagged
Protein. Irisin human, aa 32-143 / mouse, aa 29-140 is untagged. Irisin has 100% identity between mouse, rat, monkey and human. Source E. coli. Endotoxin content <0.1EU/µg purified protein LAL test Lonza. Lyophilized. Contains PBS. Purity >95% SDS-PAGE. Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin. Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.
AdipoGen Isthmin-1 human rec
Recombinant Protein. Human isthmin-1 aa 30-464 is fused at the C-terminus to a His-tag. .Source HEK 293 cells. Endotoxin content <0.01EU/µg purified protein LAL test.. Lyophilized. Contains PBS. Purity >95% SDS-PAGE. Isthmin-1 ISM1 was first identified as a gene expressed in the Xenopus midbrain hind brain organizer called isthmus, with a proposed role during early brain development. Isthmin-1 encodes a predicted ~50-kDa protein containing a signal peptide, a thrombospondin domain and an adhesion-associated domain. Isthmin-1 is important for embryonic and postnatal development. Growing evidence has shown that aberrant expression of Isthmin-1 can also affect the biological behavior of cancer. The Ism1 gene is conserved in mice and humans. A recent study showed that Ism1 is an adipokine that induces glucose uptake in human and mouse adipocytes.
AdipoGen NMNAT1 hHishighly active
Protein. Human full-length NMNAT1 aa 1-279 is fused at the N-terminus to a His-tag. Source E. coli. Endotoxin content N/A. Liquid. In 50mM sodium phosphate, pH8.0, containing 300mM sodium chloride, 2mM DTT and 10% glycerol. Purity >95% SDS-PAGE. Nuclear NMNAT isoform. Catalyzes the formation of NAD from nicotinamide mononucleotide NMN and ATP. It can also use the deamidated form of nicotinic acid mononucleotide NAMN as substrate with the same efficiency. Interacts with PARP-1/ARTD1. Protects against axonal degeneration following mechanical or toxic insults. Widely expressed.
AdipoGen Nigericin sodium salt
Chemical. CAS 28643-80-3. Formula C40H67NaO11. MW 746.94. Nigericin is an antibiotic, used as a high affinity ionophore for monovalent cations such as H, K, Na, Pb2. It shows antibacterial Gram-positive, antifungal, antitumor and antiviral activity and disrupts membrane potential of mitochondria. It sprimary use is as a NLRP3 activator in inflammasome research.
AdipoGen R-3-Hydroxymyristic acid
Chemical. CAS 28715-21-1. Formula C14H28O3. MW 244.4. Synthetic. Hydroxy fatty acid used to study its role in biological processes such as oxidative stress, inflammation and insulin resistance. Used in endotoxin and lipid A research, since it is one of two major components of bacterial Lipid A. Shows antifungal activity. Compound could be used as analytical reference in assaying food samples.
AdipoGen C6-L-HSL
Chemical. CAS 147852-83-3. Formula C10H17NO3. MW 199.3. Synthetic. N-Hexanoyl-L-homoserine lactone is a small diffusible signaling molecule involved in quorum sensing, controlling gene expression and affecting cellular metabolism. The diverse applications of this molecule include regulation of virulence in general and in cystic fibrosis, infection prevention, slime and biofilm reduction in commercial agriculture and aquaculture industries, food spoilage prevention and septicemia in fish.
AdipoGen C7-L-HSL
Chemical. CAS 177158-20-2. Formula C11H19NO3. MW 213.3. Synthetic. N-Heptanoyl-L-homoserine lactone C7-HSL is a small diffusible signaling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism. The diverse applications of this molecule include regulation of virulence, infection prevention and septicemia in fish.
Selleck Chemical LLC Express-Pick Library 30uL/well
A unique collection of 3010 chemical compounds featured different core structures and structural diversities respectively for high throughput screening (HTS) and high content screening (HCS). *For Research & Development use only. Product is not intended for drug, household, or human consumption.
AdipoGen Resveratrol
Chemical. CAS 501-36-0. Formula C14H12O3. MW 228.2. Isolated from Polygonum cuspidatum. Potent phenolic antioxidant found in grapes and red wine. Eicosanoid synthesis and platelet aggregation inhibitor. Estrogen receptor agonist. Chemopreventive. Specific inhibitor of cyclooxygenase-1 COX-1. Anti-inflammatory. Ribonucleotide reductase and DNA synthesis. Arrests cell cycle at S/G2 phase. Anticancer and antiproliferative compound. Apoptosis inducer. Protein kinase D inhibitor. Does not inhibit PKC. Autophagy inducer. Potent SIRT1 sirtuin 1 activator. Neuroprotective. Adipogenesis inhibitor. PGC-1alpha activator. Sonic hedgehog Shh signaling pathway modulator. Gli1 mRNA expression inhibitor. Downregulates Gli transcriptional activity. Cardioprotective. Anti-diabetic. Senescence modulator. Extends lifespan. Inhibitor of NLRP3 inflammasome activation.
AdipoGen MOTS-c K14Q Mutant human
Chemical. Formula C100H148N28O23S2 . C2HF3O2. MW 2174.6 . 114.0. Synthetic. The mitochondria-derived peptide MDP MOTS-c promotes biosynthesis of the endogenous AMP analog AICAR and consequently AMP-activated protein kinase AMPK. It induces cellular and systemic glucose uptake and improves insulin sensitivity and has been shown to prevent diet-induced obesity DIO in mice. This K14Q mutant of MOTS-c has been shown to be associated with exceptional longevity and may be interesting for aging research.
AdipoGen C75
Chemical. CAS 191282-48-1. Formula C14H22O4. MW 254.3. . Stable synthetic cerulenin derivative. Competitive irreversible fatty acid synthase FASN inhibitor that acts on KR, ACP and TE domains. Used to study fatty acid synthesis in metabolic disorders and cancer. Useful agent for immunometabolism research. Anorexigenic agent, activating CPT1 to accelerate fatty acid beta-oxidation. Shown to inhibit food intake through AMPK-related pathways. Cytotoxic to many cancer cell lines. Antitumor agent shown to suppress DNA replication and induce apoptosis.
AdipoGen Neuromedin U-25 human
Chemical. CAS 312306-89-1. Formula C141H203N41O38 . C2HF3O2. MW 3080.4 . 114.0. Synthetic. Active human form of NMU. Binds to two high affinity G-protein coupled receptors, NMUR1 and NMUR2, with NMUR1 predominantly expressed in the peripheral tissues and NMUR2 mainly expressed in the CNS. The activation of NMURs leads to intracellular signal transduction via calcium mobilization, phosphoinositide or PI signaling and the inhibition of cAMP production and therefore has diverse functions including contraction of smooth muscle, vasoconstriction, nociception, appetite and bone remodeling. Implicated in a number of physiological processes including the regulation of feeding, energy homeostasis and glycemic control and therefore used to target obesity and diabetes. Activator of innate lymphoid cells 2 ILC2 during inflammation, as shown in studies in mice.
AdipoGen S-Benzoylthiamine O-PO4
Chemical. CAS 22457-89-2. Formula C19H23N4O6PS. MW 466.45. S-Benzoylthiamine O-monophosphate is a lipid-soluble form of vitamin B1 thiamine. S-Benzoylthiamine O-monophosphate facilitates the action of thiamine diphosphate, a cofactor for the enzyme transketolase. The activation of transketolase enzyme accelerates the precursors of advanced glycation end products AGEs towards the pentose phosphate pathway thereby reducing the production of AGEs. The reduction in AGEs subsequently decreases metabolic stress which benefits vascular complications seen in diabetes. The anti-AGE property of S-Benzoylthiamine O-monophosphate certainly makes it effective for the treatment of diabetic neuropathy, nephropathy and retinopathy. S-Benzoylthiamine O-monophosphate appears to have a also cardioprotective role in potentiating angiogenesis and inhibiting apoptosis in diabetic complications.