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Nucleotides are composed of a nitrogenous base covalently bound to a 5-carbon sugar molecule and one or more phosphate functional groups. They are the molecules that make up the structural units of DNA and RNA.
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The Ribonucleotide Solution Set (NTP Set) consists of four separate solutions of ATP, GTP, CTP and UTP, pH 7.5 as sodium salts. The NTPs are also available as a Ribonucleotide Solution Mix .
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Kras is a member of the RAS protein family, which are a class of small GTPases involved in cell signaling. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. The protein also contains mutation of interested G12A loaded with GDP. Ready for use in the GDP/GTP exchange assay or as a negative control for Kras-RAF interaction.
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Kras is a member of the RAS protein family, which are a class of small GTPases involved in cell signaling. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. The protein also contains mutation of interested Q61K loaded with GDP. Ready for use in the GDP/GTP exchange assay or as a negative control for Kras-RAF interaction.
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Kras is a member of the RAS protein family, which are a class of small GTPases involved in cell signaling. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. The protein also contains mutation of interested Q61R loaded with GDP. Ready for use in the GDP/GTP exchange assay or as a negative control for Kras-RAF interaction.
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An adenosine analog; inhibits epinephrine-induced contraction of isolated guinea pig ileum and thoracic aorta at 10 μM; decreases arterial blood pressure and renal blood flow and increases peripheral resistance in anesthetized dogs at 1 mg/kg; inhibits tumor growth in the C3H/ST and C3HB/ST mouse models of spontaneous mammary adenocarcinomas; the most prevelant mRNA modification in eukaryotes and has roles in cell viability and development
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UTP also known as Uridine-5 -triphosphate is applicable to various molecular biology-related applications such as in vitro transcription RNA amplification and siRNA synthesis UTP can also participate in galactose metabolism where the activated form UDP-galactose is converted into UDP-glucose subsequently entering the glycogen synthesis pathway This product is a colorless and transparent aqueous solution prepared from UTP trisodium salt with purity more than 99% (HPLC) concentration 100 mM and is free from DNase and RNase contamination
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Guanosine triphosphate-13C10 (GTP-13C10) dilithium is a 13C-labeled version of Guanosine triphosphate (HY-113225), which is a native nucleotide. Derivatives of GTP may act as specific inhibitors against COVID-19.
Can be used as a tracer.
Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Stable heavy isotopes have been incorporated into drug molecules for quantitation during drug development.
Deuteration can affect the pharmacokinetic and metabolic profiles of drugs.
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GDP-D-mannose disodium is a compound containing GDP-α-D-mannose and GDP-β-D-mannose. GDP-α-D-mannose acts as a donor substrate for mannosyltransferases and is a precursor of GDP-β-L-fucose. It exhibits competitive inhibition with GTP (Ki 14.7 μM) and uncompetitive inhibition with mannose-1-P (Ki 115 μM). This product is intended for research use only.
Donor substrate for mannosyltransferases
Precursor of GDP-β-L-fucose
Competitive inhibition with GTP (Ki 14.7 μM)
Uncompetitive inhibition with mannose-1-P (Ki 115 μM)
White to off-white solid appearance
Molecular weight of 649.30
Molecular formula C16H23N5Na2O16P2
Purity of 99.68%
Storage at -20°C, sealed and away from moisture
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