Bioactive Small Molecules
A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.
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406
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406
Tocris Bioscience™ tri-GalNAc-C5-AF647
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Fluorescent ASGPR ligand. Application: flow cytometry, fluorescence microscopy
407
Tocris Bioscience™ Sorafenib
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT
| CAS | 284461-73-0 |
|---|---|
| Purity | 98% |
| Chemical Name or Material | 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C21H16ClF3N4O3 |
| Formula Weight | 464.82 |
408
| CAS | 123524-52-7 |
|---|---|
| Molecular Formula | C33H34N4O6 |
409
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Carfilzomib, Thermo Scientific™
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Carfilzomib, Thermo Scientific™
CAS: 868540-17-4 Molecular Formula: C40 H57 N5 O7 Molecular Weight (g/mol): 719.92 MDL Number: MFCD11040997 InChI Key: BLMPQMFVWMYDKT-UHFFFAOYNA-N IUPAC Name: 4-methyl-N-(1-{[4-methyl-1-(2-methyloxiran-2-yl)-1-oxopentan-2-yl]carbamoyl}-2-phenylethyl)-2-{2-[2-(morpholin-4-yl)acetamido]-4-phenylbutanamido}pentanamide SMILES: CC(C)CC(NC(=O)C(CCC1=CC=CC=C1)NC(=O)CN1CCOCC1)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)C1(C)CO1
| CAS | 868540-17-4 |
|---|---|
| Molecular Weight (g/mol) | 719.92 |
| MDL Number | MFCD11040997 |
| SMILES | CC(C)CC(NC(=O)C(CCC1=CC=CC=C1)NC(=O)CN1CCOCC1)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC(C)C)C(=O)C1(C)CO1 |
| IUPAC Name | 4-methyl-N-(1-{[4-methyl-1-(2-methyloxiran-2-yl)-1-oxopentan-2-yl]carbamoyl}-2-phenylethyl)-2-{2-[2-(morpholin-4-yl)acetamido]-4-phenylbutanamido}pentanamide |
| InChI Key | BLMPQMFVWMYDKT-UHFFFAOYNA-N |
| Molecular Formula | C40 H57 N5 O7 |
410
| CAS | 1429881-91-3 |
|---|---|
| Molecular Formula | C28H40N6O |
411
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Tocris Bioscience™ ML T7
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Tocris Bioscience™ ML T7
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Inhibitor of phosphatidylserine/CEACAM1 binding to Tim-3
| Target | CEACAM1/CD66a |
|---|---|
| CAS | 459789-75-4 |
| Purity | 0.98 |
| Chemical Name or Material | 5-(2,4-Dichlorophenyl)-3a,6a-dihydro-3-(4-methylphenyl)spiro[1H-furo[3,4-c]pyrrole-1,2'-[2H]indene]-1',3',4,6(3H,5H)-tetrone |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C27H17Cl2NO5 |
412
Tocris Bioscience™ Pomalidomide 4'-alkylC2-amine
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
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Pomalidomide-alkylC2-amine
413
Tocris Bioscience™ b-Cyclodextrin
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Cyclic complexing agent
414
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Thermo Scientific Chemicals Besifloxacin hydrochloride
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Thermo Scientific Chemicals Besifloxacin hydrochloride
CAS: 405165-61-9 Molecular Formula: C19H21ClFN3O3·HCl
| CAS | 405165-61-9 |
|---|---|
| Molecular Formula | C19H21ClFN3O3·HCl |
415
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Tocris Bioscience™ NVS-STG2
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Tocris Bioscience™ NVS-STG2
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
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STING agonist, molecular glue that causes oligomerization of STING
| Target | STING Agonists |
|---|---|
| CAS | 3030588-01-0 |
| Purity | 0.98 |
| Chemical Name or Material | 4-((4-(2-(tert-Butyl)-5,5-dimethyl-1,3-dioxan-2-yl)benzyl)amino)-3-methoxybenzoic acid |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C25H33NO5 |
416
Tocris Bioscience™ SB 431542
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SB 431542 synthesized to cGMP guidelines
| CAS | 301836-41-9 |
|---|---|
| Purity | 99% |
417
| CAS | 57710-57-3 |
|---|---|
| Synonym | Koningic Acid |
| Molecular Formula | C15H20O5 |
418
| CAS | 53902-12-8 |
|---|---|
| Color | White to Light-yellow to Green |
| Solubility | insoluble in water |
| Physical Form | Crystalline Powder |
| Health Hazard 1 | GHS07: Exclamation mark |
| Chemical Name or Material | Tranilast |
| Recommended Storage | Refrigerator +4°C |
| Merck Index | 9646 |
| Molecular Formula | C18 H17 N O5 |
| Formula Weight | 327.33 |
| Melting Point | 166.2°C to 168.2°C |
419
Tocris Bioscience™ VH 032
Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
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Greener Choice
Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”
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Small and Specialty Supplier Partner
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Inhibitor of VHL; blocks interaction of VHL and HIF-α
| Target | Von Hippel Lindau |
|---|---|
| CAS | 1448188-62-2 |
| Purity | 0.98 |
| Chemical Name or Material | (2 S,4 R)-1-(-2-Acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Recommended Storage | Store at -20°C |
| Molecular Formula | C24H32N4O4S |
