Crosslinking Reagents
Cayman Chemical PRfluorohexnsulfonIc AcId 50mg
A natural non-caloric sweetener and an active metabolite of rebaudioside A inhibits the proliferation of MDA-MB-231 cells at 250 Ug/ml active against M. tuberculosis (MIC 3.75 Ug/ml)
Cayman Chemical 1 3-DIcaffeoylquInIc AcId 50mg
A flavanonol with diverse biological activities scavenges DPPH radicals (IC50 0.235 g/ml) and decreases AAPH-induced ROS generation in human erythrocytes (6 g/ml) dose-dependently decreases proliferation and increases apoptosis in human liver carcinoma HepG2 cells decreases tumor volume by 43.5 in a mouse xenograft model of HepG2 cells (500 mg/kg per day) binds to GABAA receptors in rat cortical membrane reparations (IC50 4.36 M) dose-dependently reduces LORR in ethanol-intoxicated rats improves cognitive deficits in a mouse model of Alzheimers disease (2 mg/kg for three months)
Cayman Chemical CryptochlorogenIc AcId 50mg
A Bcl-6 inhibitor (Ki 147 UM) selective for Bcl-6 over Kaiso HIC1 and PLZF at 50 UM cytotoxic against SU-DLH-6 SU-DLH-4 Farage OCI-LY7 OCI-LY1 and OCI-LY10 DLBCL cells (GI50s 0.024-0.936 mM) increases expression of ATR TP53 CD69 p21 and CD44 in SU-DLH-6 and SU-DHL-4 cells at 50 UM reduces tumor growth in OCI-LY7 and SU-DHL-6 mouse xenograft models at 50 mg/kg
Cayman Chemical CorosolIc AcId 50mg
A TASK-1 potassium channel blocker (IC50 16 nM) selective for TASK-1 over TASK-3 channels in a QPatch assay (IC50 990 nM) acts as an antagonist of mGluR5 (IC50 1 35 M)
Cayman Chemical ChIcorIc AcId 50mg
A glycine-conjugated form of ursodeoxycholic acid has antioxidant effects in vitro in Barretts esophagus cells and primary cultured rat neurons reduces the levels of inflammatory cytokines and prevents cell death induced by unconjugated bilirubin in an astroglial cell model of neonatal hyperbilirubinemia decreases the severity of symptoms and increases the amount of A. muciniphila in a mouse model of colitis at 500 mg/kg per day
Cayman Chemical TIaprofenIc AcId 50mg
A coumarin with anticancer activity decreases proliferation and cell invasion induced by FBS in H1299 NSCLCs at 10 UM decreases VEGF secretion in A549 and H1299 cells and inhibits capillary-like structure formation by HUVECs decreases proliferation of U937 human leukemia cells (IC50 40 UM) reduces tumor growth in a U937 mouse xenograft model at 30 mg/kg
Cayman Chemical FlutIcason PropIonate 10mg
A substrate of IMPDH a NAD -dependent enzyme that generates xanthosine monophosphate in a rate-limiting step in DNA RNA and glycoprotein synthesis also involved in potentiating the umami taste sensation
Cayman Chemical HomogentIsIc AcId 50mg
A potent synthetic agonist of GPR55 (EC50 0 26 UM) does not act at the related kynurenic acid receptor GPR35 and is a weak antagonist of CB1 and CB2 (IC50s 21 8 and 15 1 UM respectively)
Cayman Chemical DIsuccInImIdyl Glutarate 50mg
A dual inhibitor of EGFR and HER2 (IC50s 92 and 59 nM respectively) selective for EGFR and HER2 over a panel of 12 kinases (IC50s 5000 nM) but does inhibit VEGFR2 and Src (IC50s 800 and 1400 nM respectively) inhibits the proliferation of NCI H508 colorectal cancer cells expressing wild-type or mutant forms of HER2 (IC50s 0 2-3 nM) reduces tumor growth in BT474 breast and SKOV3 ovarian cancer mouse xenograft models at 40 mg/kg
Cayman Chemical Halobetasol PropIonate 25mg
A minor metabolite of fenbendazole formed by oxidation of oxfendazole a product of fenbendazole oxidation
Cayman Chemical GlycohyodeoxycholIc AcId 50mg
A fat-soluble dietary nutrient that is essential for the synthesis of proteins important for blood-clotting bone metabolism and cell growth
Cayman Chemical 2propyl4PentenoIc AcId 50mg
An activator of RAD51 (Kd 48-107 for human RAD51) a potent enhancer of CRISPR-mediated genome editing
Cayman Chemical trns-PetroselInIc AcId 50mg
A thiol-reactive fluorescent probe fluorescence intensity increases when bound to cysteine residues ex/em 387/468 respectively
Cayman Chemical RIcInlaIdIc AcId 50mg
A potent selective inhibitor of Y-secretase (IC50 4 nM) that blocks both AB40 and Notch processing (IC50s 14 and 5 nM respectively) orally active against cancer xenograft models altering gene expression related to angiogenesis and cell differentiation
Cayman Chemical DIsuccInImIdyl Glutarate 5mg
A selective ligand for the lipid-binding protein NUCB1 blocking binding of the probe arachidonoyl ethanolamide-diazirine with an IC50 value of 3 3 UM