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Reagents containing reactive end groups that respond to the presence of specific functional groups by forming bonds between polymer chains. Ideal for various applications including conjugation reactions, biomolecule labeling, and molecular purification.
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A metabolite of lithocholic acid; water soluble and the primary form of lithocholic acid in the bile duct; forms a complex with calcium in vitro; biliary secretion increased in a rat model of streptozotocin-induced diabetes
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A thyroid hormone derivative; inhibits copper-induced lipid peroxidation of LDL isolated from human plasma at 1 µM; increases urinary and fecal excretion of sterols and prevents high-fat diet-induced increases in liver lipid and cholesterol levels, in rats at 5 mg/100 g diet
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Amine-reactive PES is a novel amino-reactive electron mediator. The mediator is able to be linked to enzymes such as glucose dehydrogenase by a covalent bond, and is expected to be applied to next generation biosensors. By modification of enzyme with Amine-reactive PES, the mediator which binds to the enzyme surface is able to transfer the electrons from reduced co-factor to the electrode. This sensing system can be useful for reducing mediator leakage from the electrode and replacement of expensive metal complex compounds. Dojindo has various reagents for biosensor research. (https://www.dojindo.com/surface-chemistry/)
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MF: C4 H4 N O6 S . Na, MW: 217.13, Alternative Names: Sulfo NHS; Hydroxy-2,5-dioxopyrrolidine-3-sulfonicacid; S-NHS. N-hydroxysulfosuccinimide (Sulfo-NHS) is used in conjunction with EDC-HCl (EDAC-HCl) to convert carboxyl groups to Sulfo-NHS esters which react with primary amines.
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Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is a linker-payload conjugate and active metabolite used in antibody-drug conjugate (ADC) research. It inhibits tubulin polymerization and is used for linker development, payload characterization, and in vitro pharmacology studies.
High purity (>99.6%) suitable for analytical work.
Molecular weight 1103.71 g·mol⁻¹.
Chemical formula C53H75ClN6O15S.
Inhibits tubulin polymerization for mechanism studies.
Intended for ADC linker-payload and metabolite research.
Provided as a solid convenient for storage and handling.
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An antioxidant derived from rosemary and common sage that inhibits lipid peroxidation and scavenges peroxyl radicals; cytotoxic towards various human cancer cell lines, reducing cell viability to 13-30% at 6.25 UG/ml
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A long-chain ω-3 PUFA; comprises approximately 40% of total brain PUFAs and is abundant in grey matter and retinal membranes; typically represents 0.52-7.5% of human total plasma fatty acids; has roles in several physiological and pathological processes
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An amino bisphosphonate that inhibits FPP synthase (IC50 = 388.2 nM in a cell-free assay); reduces the number of RAW 264.7 cells expressing TRAP in an in vitro model of osteoclastogenesis induced by co-culture with CRL-12257 osteoblasts from 0.001-100 µM; inhibits FGF2-induced proliferation and tube formation in HUVECs at 30 µM; reduces the loss of trabeculae and increases bone density in the tibial metaphysis of growing rats at 0.1 mg/kg per day s.c.
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