Crosslinking Reagents
ABclonal Technology C-Reactive Protein (CRP) Rabbit pAb
This gene encodes a member of the pentraxin family, which includes proteins involved in complement activation and regulation. The protein has a calcium-dependent ligand-binding domain with a distinctive beta-jellyroll structure and exists as a circulating pentamer or tissue-associated monomer. It plays a key role in host defense by recognizing pathogens and damaged cells, promoting their clearance through interaction with immune effectors. Its plasma levels rise significantly during the acute phase response to injury, infection, or inflammation. Elevated expression is linked to SARS-CoV-2 infection.
Medchemexpress LLC Dbco-sulfo-link-biotin | 1363444-70-5 | 653.77 g·mol⁻¹ | C31H35N5O7S2 | 1 MG
DBCO-Sulfo-Link-biotin is a water-soluble, cleavable click-chemistry linker that combines a dibenzocyclooctyne (DBCO) reactive group with a biotin affinity tag. It enables copper-free strain-promoted alkyne-azide cycloaddition (SPAAC) for labeling azide-containing biomolecules and is used in biotinylation, protein labeling, and antibody-drug conjugate linker synthesis.
- Enables copper-free strain-promoted alkyne-azide cycloaddition (SPAAC).
- Provides a biotin tag for affinity capture and detection.
- Sulfo linker increases water solubility for aqueous bioconjugation.
- Suitable for biotinylation, protein labeling, and ADC linker incorporation.
Medchemexpress LLC Trans-Sulfo-SMCC | 1286837-77-1 | 90.9% | 414.39 | C16H18N2O9S | 10 MG
trans-Sulfo-SMCC is a non-cleavable, membrane-permeable antibody-drug conjugate (ADC) crosslinker commonly used as an ADC linker reagent in conjugation workflows.
- Non-cleavable, membrane-permeable crosslinker suitable for ADC applications.
- CAS number 1286837-77-1 for unambiguous identification.
- Molecular formula C16H18N2O9S and molecular weight 414.39 g/mol.
- Typical purity around 90.9% as supplied.
- Available in small-milligram quantities for research use.
Medchemexpress LLC Bis(3-sulfo-N-succinimidyl) suberate disodium salt | 127634-19-9 | MFCD00054982 | 98.0% | 572.43 | C16H18N2Na2O14S2 | 10 MG
BS3 Crosslinker disodium is a water-soluble, non-cleavable, homobifunctional amine-reactive crosslinker used to form stable amide bonds between primary amines. It is commonly used for antibody-drug conjugate synthesis, protein crosslinking, and bioconjugation workflows. CAS 127634-19-9; molecular weight 572.43; typical purity 98%.
- Water-soluble homobifunctional crosslinker for amine-to-amine coupling.
- Non-cleavable sulfo-NHS ester chemistry produces stable amide bonds.
- Membrane-impermeable, suitable for surface and extracellular protein crosslinking.
- Widely used in antibody-drug conjugate design and general bioconjugation.
- Provided as a solid powder with high stated purity for research use only.
- Available in small-scale package sizes for laboratory experiments.
Medchemexpress LLC 3,3'-dithiobispropionic acid bis-sulfosuccinimidyl ester disodium salt | 81069-02-5 | MFCD00054980 | 98.9% | 564.54 g/mol | C14H16N2O14S4 | 5 MG
DTSSP (3,3'-dithiobis(sulfosuccinimidyl propionate)) is a cleavable disulfide-containing crosslinker used in biochemical research as a reversible protein crosslinker and as a linker in antibody-drug conjugate (ADC) synthesis. It couples to primary amines via NHS-ester chemistry to form stable amide bonds and is designed to be cleaved under reducing conditions to release linked moieties.
- Cleavable disulfide-containing crosslinker enabling reversible linkage.
- Reacts with primary amines via NHS-ester chemistry to form stable amide bonds.
- Cleavable under reducing conditions for controlled release of conjugates.
- Suitable for antibody-drug conjugate linker synthesis and protein crosslinking.
- Available in small laboratory pack sizes for research use.
Medchemexpress LLC (2-Pyridyldithio)-PEG4-propargyl | 2170240-99-8 | 98.5% | C16H23NO4S2 | 50 MG
(2-Pyridyldithio)-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs connect two different ligands, one for an E3 ubiquitin ligase and the other for a target protein, to degrade target proteins using the intracellular ubiquitin-proteasome system.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Connects two ligands for targeted protein degradation
- Utilizes the intracellular ubiquitin-proteasome system
- Appears as a colorless to light yellow liquid
- Density of 1.18±0.1 g/cm3
Medchemexpress LLC BS3 crosslinker (disodium) | 127634-19-9 | not stated | 98.0% | 572.43 g/mol | C16H18N2Na2O14S2 | 50 MG
BS3 Crosslinker disodium is a water-soluble, non-cleavable homobifunctional amine crosslinker used for bioconjugation and antibody-drug conjugate synthesis. It contains sulfosuccinimidyl reactive esters that selectively react with primary amines to form stable amide bonds, enabling protein crosslinking and labeling under aqueous conditions. The reagent is supplied as a solid of high purity and requires sealed storage away from moisture and light; in solution, long-term storage at -80°C is recommended.
Medchemexpress LLC Trans-sulfo-SMCC | 1286837-77-1 | 90.9% | 414.39 g/mol | C16H18N2O9S | 50 MG
trans-Sulfo-SMCC is a non-cleavable, membrane-permeable antibody-drug conjugate (ADC) crosslinker used to form stable, non-cleavable linkages between proteins and small-molecule payloads in research and bioconjugation workflows. It contains functional groups reactive toward primary amines and sulfhydryls, enabling a range of conjugation strategies.
- Non-cleavable linker for producing stable conjugates.
- Membrane permeable to facilitate intracellular delivery of conjugated payloads.
- Reactive toward primary amines and sulfhydryls for flexible conjugation chemistry.
- Available in multiple sizes; commonly supplied as 50 MG vials.
- Purity approximately 90.9% as reported on the product page.
- Solid, white to off-white appearance; store powder at -20°C for long-term stability.
TARGETMOL CHEMICALS INC SULFO-SMCC SODIUM 200MG
Also available in 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Sulfo-SMCC sodium is a commonly used hetero-bifunctional non-cleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups respectively. purity: 99%
Medchemexpress LLC DSG-PEG (MW 2000) | 308805-39-2 | 100.0% | 2000 Da (average) | C130H258O50 (average) | 50 MG
DSG-PEG (average MW 2000 Da) is a PEGylated lipid supplied as a high-purity solid for use in liposome and lipid nanoparticle formulation. It provides a methoxy-PEG chain anchored to a distearoyl glycerol lipid to incorporate into bilayers and modify surface properties.
- Provides steric stabilization to liposomes and lipid nanoparticles.
- Incorporates into lipid bilayers via a distearoyl glycerol anchor.
- Average PEG molecular weight ~2000 Da for controlled hydration layer.
- High purity solid suitable for research-scale formulation.
- Compatible with common solvents used in lipid film hydration and nanoparticle assembly.
- Powder storage at -20°C preserves stability for long-term storage.