Protein Modification Reagents
Chemscene ChemScene | Azido-PEG5-amine | 1G | CS-0114401 | 0.97 | 516493-93-9| MFCD16619318 | 306.36
ChemScene | Azido-PEG5-amine | 1G | CS-0114401 | 0.97 | 516493-93-9| MFCD16619318 | 306.36
Medchemexpress LLC Bis-Mal-Lysine-PEG4-TFP ester | 1426164-53-5 | 98.0% | C37H45F4N5O13 | 100 MG
Bis-Mal-Lysine-PEG4-TFP ester is a PEG-based PROTAC linker utilized in PROTAC synthesis. PROTACs feature two distinct ligands joined by a linker: one targeting an E3 ubiquitin ligase, the other the protein of interest. This mechanism enables PROTACs to leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Enables selective degradation of target proteins
Medchemexpress LLC DSPE-PEG-azide | 90.6% | 2000 Da (average) | 25 MG
DSPE-PEG-Azide (MW 2000) is an azide-functionalized PEG-lipid supplied as a white to off-white solid for research use. It provides an azide handle for click-chemistry conjugation and is used to PEGylate lipid surfaces to modify nanoparticle and liposome properties.
- Provides azide functional group for copper-catalyzed azide-alkyne cycloaddition.
- Enables surface PEGylation of liposomes and nanoparticles to improve colloidal stability and circulation.
- Average molecular weight about 2000 Da, giving defined PEG chain length.
- Soluble in DMSO (100 mg/mL) and formulatable for in vivo dosing at ≥2.5 mg/mL with common vehicles.
- Supplied as a white to off-white solid; store powder at -20 °C.
- Reported purity approximately 90.6%.
![eMolecules 2183440-72-2 | N-(Azido-PEG3)-NH-PEG3-acid HCl salt | Broadpharm422.479 | C17H34N4O8 | 95.000 | OC(=O)CCOCCOCCOCCNCCOCCOCCOCCN=[N+]=[N-] | 250mg | 550804447](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502203497.JPG-250.jpg)
eMolecules 2183440-72-2 | N-(Azido-PEG3)-NH-PEG3-acid HCl salt | Broadpharm422.479 | C17H34N4O8 | 95.000 | OC(=O)CCOCCOCCOCCNCCOCCOCCOCCN=[N+]=[N-] | 250mg | 550804447
N-(Azido-PEG3)-NH-PEG3-acid HCl salt | Broadpharm | 2183440-72-2422.479 | C17H34N4O8 | 95.000 | OC(=O)CCOCCOCCOCCNCCOCCOCCOCCN=[N+]=[N-] | 250mg | 550804447
Medchemexpress LLC Azido-PEG20-alcohol | 1637297-21-2 | >98% | C40H81N3O20 | 100 MG
Azido-PEG20-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent containing an Azide group, enabling copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
=O)[N+]([O-])=O | 1g | 112541440](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502202926.JPG-250.jpg)
eMolecules 858126-76-8 | DNP-PEG4-acid | Broadpharm | MFCD13184986 | 431.398 | C17H25N3O10 | 0.000 | OC(=O)CCOCCOCCOCCOCCNc1ccc(cc1[N+]([O-])=O)[N+]([O-])=O | 1g | 112541440
DNP-PEG4-acid | Broadpharm | 858126-76-8 | MFCD13184986 | 431.398 | C17H25N3O10 | 0.000 | OC(=O)CCOCCOCCOCCOCCNc1ccc(cc1[N+]([O-])=O)[N+]([O-])=O | 1g | 112541440
eMolecules DBCO-PEG8-Maleimide | Broadpharm |850.963 | C44H58N4O13 | 0.000 | O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O)NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 25mg | 686678581
DBCO-PEG8-Maleimide | Broadpharm |850.963 | C44H58N4O13 | 0.000 | O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O)NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 25mg | 686678581
Medchemexpress LLC Mc-PEG4-Val-Ala-PAB-Exatecan | 99.7% | 1153.21 | C58H69FN8O16 | 5 MG
Mc-PEG4-Val-Ala-PAB-Exatecan is an ADC drug-linker conjugate composed of a cleavable Val-Ala-PAB linker and the DNA topoisomerase I inhibitor Exatecan; supplied for research use in milligram quantities for ADC development and linker-payload studies.
- Purity: 99.7%
- Molecular weight: 1153.21
- Chemical formula: C58H69FN8O16
- Physical state: Solid
- Available in 1 MG, 5 MG, 10 MG, 25 MG, 50 MG, 100 MG
- Storage: -20°C sealed; in solvent -80°C (6 months), -20°C (1 month)
- Solubility in DMSO: ≥ 100 mg/mL
Medchemexpress LLC DBCO-PEG4-Biotin | 1255942-07-4 | 99.5% | 25 MG
DBCO-PEG4-Biotin is an azadibenzocyclooctyne-biotin derivative containing a biotin group and 4 PEGs. It is a versatile biotinylation reagent used for introducing a biotin moiety to azide-labeled biomolecules via copper-free strain-promoted alkyne-azide click chemistry (SPAAC) reaction. This reagent contains a DBCO group that can undergo SPAAC with molecules containing azide groups.
- Azadibenzocyclooctyne-biotin derivative
- Contains a biotin group and 4 PEGs
- Versatile biotinylation reagent
- Introduces a biotin moiety to azide-labeled biomolecules
- Uses copper-free strain-promoted alkyne-azide click chemistry (SPAAC) reaction
- DBCO group can undergo SPAAC with molecules containing azide groups
Medchemexpress LLC Propargyl-PEG4-Tos | 875770-32-4 | 99.3% | 5 G
Propargyl-PEG4-Tos is a PEG-based PROTAC linker used in the synthesis of PROTACs and as a cleavable ADC linker in the synthesis of antibody-drug conjugates (ADCs). It also functions as a click chemistry reagent featuring an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Cleavable ADC linker
- Utilized in the synthesis of antibody-drug conjugates (ADCs)
- Click chemistry reagent
- Features an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules
Medchemexpress LLC DNP-PEG4-acid | 858126-76-8 | 100 MG
DNP-PEG4-acid is a PEG-based PROTAC linker designed for the synthesis of PROTACs. PROTACs are compounds that exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins, consisting of two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
- Relevant for cancer and cancer targeted therapy research