Protein Modification Reagents
Medchemexpress LLC Aminooxy-PEG1-azide | 2100306-70-3 | MFCD30723212 | 98.0% | 146.15 g/mol | C4H10N4O2 | 5 MG
Aminooxy-PEG1-azide is a short bifunctional polyethylene glycol (PEG) linker bearing an aminooxy group and an azide group. It is designed for chemical biology and bioconjugation applications where orthogonal conjugation is required, enabling oxime ligation at one terminus and click chemistry at the other. Intended for research use only.
- Enables oxime ligation with aldehydes and ketones.
- Participates in copper-catalyzed and strain-promoted azide-alkyne cycloadditions.
- Provides a short PEG spacer to improve aqueous solubility and reduce steric hindrance.
- Suitable for linker construction in proteolysis targeting chimeric molecule (PROTAC) and bioconjugation workflows.
- Reported purity approximately 98%, compatible with research applications.
Medchemexpress LLC DOTA-PEG5-amine | 98.0% | 666.76 | 50 MG
DOTA-PEG5-amine is a PEG-based PROTAC linker designed for the synthesis of PROTACs. These molecules feature two ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other a target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade specific target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- For research use only
Cayman Chemical AzIdo-dPEG7-amIn 10mg
A heterobifunctional PEGylated linker; contains a reactive NH2 end group, as well as an azide functional group for use in click chemistry reactions; has been used as a linker in the synthesis of bivalent mTOR inhibitors
eMolecules 35164-96-6 | Tos-PEG21-Tos | Broadpharm | MFCD30458052 | 1207.440 | C54H94O25S2 | 95.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOS(=O)(=O)c1ccc(C)cc1 | 1g | 311074443
Tos-PEG21-Tos | Broadpharm | 35164-96-6 | MFCD30458052 | 1207.440 | C54H94O25S2 | 95.000 | Cc1ccc(cc1)S(=O)(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOS(=O)(=O)c1ccc(C)cc1 | 1g | 311074443
eMolecules 16-(Amine-PEG4-ethylcarbamoyl)pentadecanoic-t-butyl ester | Broadpharm |560.817 | C30H60N2O7 | 95.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCCCC(=O)NCCOCCOCCOCCOCCN | 100mg | 795361477
16-(Amine-PEG4-ethylcarbamoyl)pentadecanoic-t-butyl ester | Broadpharm |560.817 | C30H60N2O7 | 95.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCCCC(=O)NCCOCCOCCOCCOCCN | 100mg | 795361477
eMolecules 2055042-60-7 | N-(Boc-PEG3)-N-bis(PEG2-alcohol) | Broadpharm | MFCD30182039 | 556.694 | C25H52N2O11 | 97.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCN(CCOCCOCCO)CCOCCOCCO | 500mg | 309208953
N-(Boc-PEG3)-N-bis(PEG2-alcohol) | Broadpharm | 2055042-60-7 | MFCD30182039 | 556.694 | C25H52N2O11 | 97.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCN(CCOCCOCCO)CCOCCOCCO | 500mg | 309208953
Medchemexpress LLC PEG5-(CH2CO2H)2 | 77855-75-5 | MFCD29079379 | 99.3% | 310.30 | C12H22O9 | 1G
HOOCCH2O-PEG4-CH2COOH is a symmetric PEG-based dicarboxylic acid linker used as a flexible, hydrophilic spacer for the construction of bifunctional degraders and other conjugates. It provides two carboxylic acid termini for standard coupling chemistries, and its PEG4 backbone imparts solubility and conformational flexibility suited for PROTAC and homo-PROTAC synthesis.
- Symmetric PEG4 dicarboxylic acid linker.
- Provides carboxylic acid termini for straightforward coupling reactions.
- PEG backbone increases solubility and flexibility.
- Designed for use in PROTAC and homo-PROTAC synthesis.
- High purity suitable for research applications.
- Typically supplied in small pack sizes for lab-scale synthesis.
eMolecules 1286281-32-0 | Amino-PEG6-t-butyl ester | Broadpharm | MFCD13184944 | 409.520 | C19H39NO8 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCN | 1g | 112541647
Amino-PEG6-t-butyl ester | Broadpharm | 1286281-32-0 | MFCD13184944 | 409.520 | C19H39NO8 | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCN | 1g | 112541647
eMolecules 1186025-29-5 | Hydroxy-PEG24-t-butyl ester | Broadpharm | MFCD13185018 | 1203.458 | C55H110O27 | 95.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO | 1g | 298819405
Hydroxy-PEG24-t-butyl ester | Broadpharm | 1186025-29-5 | MFCD13185018 | 1203.458 | C55H110O27 | 95.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO | 1g | 298819405
Medchemexpress LLC Mal-PEG8-Val-Cit-PAB-MMAF | 100.0% | 1640.95 | C81H129N11O24 | 5 MG
Mal-PEG8-Val-Cit-PAB-MMAF is a drug-linker conjugate used in antibody-drug conjugate (ADC) research. It couples the tubulin inhibitor MMAF to a cleavable Val-Cit-PAB peptide linker via an 8-unit PEG spacer and a maleimide reactive group, enabling site-selective conjugation and protease-triggered payload release.
- Cleavable Val-Cit-PAB peptide linker enables protease-triggered payload release.
- Maleimide reactive group for cysteine-directed conjugation.
- PEG8 spacer improves solubility and reduces steric hindrance.
- High purity suitable for research applications.
- Molecular weight 1640.95, molecular formula C81H129N11O24.
- Available in small-mass packs suitable for ADC synthesis and development.
Medchemexpress LLC Me-tet-peg4-cooh | 2141976-30-7 | 98.7% | 477.51 g·mol⁻¹ | C22H31N5O7 | 10 MG
Me-Tet-PEG4-COOH is an ADC linker containing four polyethylene glycol (PEG) units and a tetrazine group that enables inverse electron demand Diels-Alder (iEDDA) bioorthogonal conjugation with TCO-containing partners. Intended for research use in bioconjugation and ADC development.
- Purity: 98.68%
- Molecular weight: 477.51 g·mol⁻¹
- Chemical formula: C22H31N5O7
- Cas number: 2141976-30-7
- Appearance: pale purple to purple solid
- Solubility: DMSO 125 mg/mL (requires ultrasonic; use newly opened DMSO)
- Storage: powder -20°C up to 3 years; in solvent -80°C for 6 months, -20°C for 1 month
- Product type: ADC linker
Medchemexpress LLC Boc-N-Amido-PEG4-propargyl | 1219810-90-8 | 99.7% | C16H29NO6 | 100 MG
Boc-N-Amido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs themselves contain two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase, and the other for the target protein, enabling PROTACs to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
