Protein Modification Reagents
Medchemexpress LLC 3,4-dibromo-mal-peg2-amine TFA | 2296708-07-9 | MFCD31814444 | 98.0% | 500.06 g·mol⁻1 | C12H15Br2F3N2O6 | 5 MG
3,4-Dibromo-Mal-PEG2-amine TFA is a PEG-based PROTAC linker supplied as the trifluoroacetic acid salt. It contains a dibromomaleimide reactive handle and a PEG2 spacer terminating in a primary amine, and is intended for use in assembling bifunctional molecules and conjugation chemistry.
- PEG-based linker with a short PEG2 spacer.
- Dibromomaleimide group for selective thiol conjugation.
- Primary amine terminus supplied as TFA salt for improved stability.
- High purity (≈98%) and supplied as a solid.
- Suitable for PROTAC synthesis and bifunctional small-molecule assembly.
- Available in small pack sizes for research-scale use.
Medchemexpress LLC Biotin-PEG4-amide-Alkyne | 1006592-45-5 | 95.0% | C24H40N4O7S | 25 MG
Biotin-PEG4-amide-Alkyne is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups. PROTACs leverage the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Click chemistry reagent
- Contains an alkyne group for CuAAc reactions
- Degrades target proteins via the ubiquitin-proteasome system
Medchemexpress LLC Azido-PEG4-Amido-Tris | 1398044-55-7 | 96.4% | C15H30N4O8 | 50 MG
Azido-PEG4-Amido-Tris is a PEG-based PROTAC linker used in the synthesis of PROTACs. This compound functions as a click chemistry reagent, featuring an azide group. It can engage in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing alkyne groups, and can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent with an azide group
- Capable of copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Cayman Chemical Boc-NH-PEG3-OH 500mg
A PEGylated building block; has been used as a spacer in biotinylated heterobifunctional cross-linker agents; has been used as a spacer in near infrared imaging probes for CYP1B1, which is expressed in a variety of tumors; has also been used in the synthesis of graftable peptidomimetics that bind to human αVβ3 integrin and inhibit adhesion of human osteoprogenitor cells to vitronectin
Medchemexpress LLC Ethanol, 2-[2-[2-[2-[(2,4-dinitrophenyl)amino]ethoxy]ethoxy]ethoxy]- | 1807520-99-5 | 97.9% | C14H21N3O8 | 250 MG
DNP-PEG4-alcohol is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are compounds that contain two different ligands connected by a linker; one targets an E3 ubiquitin ligase and the other targets a protein of interest. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker.
- Used in the synthesis of PROTACs.
- Facilitates selective degradation of target proteins.
![eMolecules 20-(Azide-PEG3-ethylcarbamoyl)nonadecanoic-t-butyl ester | Broadpharm |598.870 | C32H62N4O6 | 98.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCCCCCCCC(=O)NCCOCCOCCOCCN=[N+]=[N-] | 100mg | 784455359](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502473285.JPG-250.jpg)
eMolecules 20-(Azide-PEG3-ethylcarbamoyl)nonadecanoic-t-butyl ester | Broadpharm |598.870 | C32H62N4O6 | 98.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCCCCCCCC(=O)NCCOCCOCCOCCN=[N+]=[N-] | 100mg | 784455359
20-(Azide-PEG3-ethylcarbamoyl)nonadecanoic-t-butyl ester | Broadpharm |598.870 | C32H62N4O6 | 98.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCCCCCCCC(=O)NCCOCCOCCOCCN=[N+]=[N-] | 100mg | 784455359
![eMolecules 2141976-33-0 | endo-BCN-Peg3-maleimide | Combi-Blocks, Inc.519.595 | C26H37N3O8 | 95.000 | O=C(CCN1C(=O)C=CC1=O)NCCOCCOCCOCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 100mg | 569346425](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC2318776.JPG-250.jpg)
eMolecules 2141976-33-0 | endo-BCN-Peg3-maleimide | Combi-Blocks, Inc.519.595 | C26H37N3O8 | 95.000 | O=C(CCN1C(=O)C=CC1=O)NCCOCCOCCOCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 100mg | 569346425
endo-BCN-Peg3-maleimide | Combi-Blocks, Inc. | 2141976-33-0519.595 | C26H37N3O8 | 95.000 | O=C(CCN1C(=O)C=CC1=O)NCCOCCOCCOCCNC(=O)OC[C@@H]1[C@@H]2CCC#CCC[C@H]12 | 100mg | 569346425
Cayman Chemical Boc-NH-PEG3-CH2CoH 25mg
A building block; has been used as a linker in the synthesis of PROTACs targeting MEK; has been used as a spacer in the synthesis of radiolabeled probes for dual labeling of tumor integrin αVβ3 and GRPR in tumor tissue in vivo
eMolecules 1352827-47-4 | Fmoc-PEG3-NHS ester | Broadpharm | MFCD28142471 | 540.569 | C28H32N2O9 | 0.000 | O=C(CCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12)ON1C(=O)CCC1=O | 1g | 263744723
Fmoc-PEG3-NHS ester | Broadpharm | 1352827-47-4 | MFCD28142471 | 540.569 | C28H32N2O9 | 0.000 | O=C(CCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12)ON1C(=O)CCC1=O | 1g | 263744723
Medchemexpress LLC Mal-PEG2-Val-Cit-PABA | 1662687-83-3 | 98.9% | 590.63 | C27H38N6O9 | 5 MG
Mal-PEG2-Val-Cit-PABA is a cleavable antibody-drug conjugate (ADC) linker designed for synthesis of ADCs. It features a maleimide reactive handle, a PEG2 spacer for improved hydrophilicity, and a Val-Cit-PABA cleavage motif that enables protease-mediated release of payloads in target cells.
- Cleavable Val-Cit-PABA motif for protease-triggered payload release.
- Maleimide functional group for thiol-selective conjugation to antibodies.
- PEG2 spacer increases hydrophilicity and may reduce aggregation.
- High chemical purity suitable for research and ADC synthesis.
- Stable when stored as powder at -20°C; follow recommended solvent storage conditions.
Medchemexpress LLC BCN-endo-PEG2-maleimide | 2675364-08-4 | 98.1% | 475.53 | C24H33N3O7 | 25 MG
A bifunctional linker reagent containing an endo-bicyclononyne reactive group and a maleimide separated by a PEG2 spacer, designed for strain-promoted azide-alkyne cycloaddition and thiol conjugation in bioconjugation and drug-delivery workflows.
- Contains endo-bicyclononyne and maleimide reactive groups.
- Peg2 spacer provides flexibility and solubility.
- Enables catalyst-free strain-promoted azide-alkyne cycloaddition (SPAAC) with azides.
- Compatible with maleimide-mediated thiol conjugation.
- High purity and defined molecular weight for reproducible conjugation.
Medchemexpress LLC Amino-PEG6-amido-bis-PEG5-N3 | 1147.31 g/mol | C48H94N10O21 | 100 MG
Amino-PEG6-amido-bis-PEG5-N3 is a cleavable PEG-based linker designed for bioconjugation and click chemistry applications. It contains an azide functional group and an amino terminus, providing an azide handle suitable for copper-catalyzed azide-alkyne cycloaddition and formation of antibody-drug conjugates or other bioconjugates.
- Cleavable 11-unit PEG linker for ADC and bioconjugate synthesis.
- Azide functional group compatible with CuAAC (click chemistry).
- Molecular weight 1,147.31 g/mol; formula C48H94N10O21.
- Appearance oil; colorless to light yellow.
- Solubility in DMSO ≥ 100 mg/mL.
- Storage sealed, away from moisture and light; recommended -20°C (in solvent: -80°C, 6 months; -20°C, 1 month).
- Available in multiple pack sizes including 100 mg.
Med Vet International Oxy Hose Assembly Female Ohio & Male Ohio, J0538E, Each
Female Ohio x Male Ohio
eMolecules 17598-96-8 | PEG-14 | Broadpharm | MFCD20926392 | 590.704 | C26H54O14 | 96.000 | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO | 250mg | 138794155
PEG-14 | Broadpharm | 17598-96-8 | MFCD20926392 | 590.704 | C26H54O14 | 96.000 | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO | 250mg | 138794155
Medchemexpress LLC Endo-BCN-PEG4-acid | 1881221-47-1 | 99.3% | 441.52 g/mol | C22H35NO8 | 100 MG
endo-BCN-PEG4-acid is a BCN-containing PEG4 linker used for click chemistry and bioconjugation, typically employed in the synthesis of antibody-drug conjugates (ADCs) via strain-promoted alkyne-azide cycloaddition (SPAAC).
- Cleavable four-unit PEG linker suitable for ADC and PROTAC synthesis.
- Contains a strained BCN moiety for efficient SPAAC with azide-containing partners.
- High purity for conjugation applications.
- Liquid form, colorless to light yellow, with recommended low-temperature storage.
- Available as a 100 MG pack for laboratory use.