Protein Modification Reagents
Epigentek Inc DTT Solution (1 ml, 500 mM)
DTT, also known as Cleland's Reagent, is a particularly strong reducing agent, owing to its high conformational proprensity to form a six member ring with an internal disulfide bond. It has a redox potential of -0.33 V @ pH 7. It is used for many protein research applications, including reducing polyacrylamide electrophoresis (SDS-PAGE). The 500 mM stock solution can be directly used to achieve the amount of reducing agent required for your specific application.
Medchemexpress LLC PROTAC EGFR degrader 4 | 2882845-50-1 | 99.7% | 995.29 | 1 MG
PROTAC EGFR degrader 4 is a potent PROTAC targeting mutant EGFR. It induces degradation of EGFRdel19 and EGFRL858R/T790M with DC50s of 0.51 and 126 nM, respectively. The compound significantly inhibits the growth of HCC827 and H1975 cell lines with IC50s of 0.83 and 203.1 nM, respectively. The induced EGFR degradation is associated with autophagy.
- Displays excellent activity of inducing EGFRdel19 degradation with a DC50 value of 0.51 nM.
- Dramatically reduces the phosphorylation of EGFR and its downstream effector Akt in HCC827 and H1975 cell lines.
- Induces HCC827 cell line to undergo apoptosis at concentrations of 10 and 100 nM.
- Arrests both HCC827 and H1975 cell lines at G1 phase.
Cayman Chemical VH 032 LInker 2 10mg
A VHL Ligand 1 derivative; comprises the VHL ligand domain and PEG linker of the BET inhibitor-containing PROTACs MZ2 and MZP-55
Broadpharm Amino-PEG7-alcohol | 1425973-14-3 | MFCD28385479 | 5g
Amino-PEG7-alcohol | Putity: 98% | MW: 325.4 | 1425973-14-3 | MFCD28385479 | 5g
Cayman Chemical ANTIBODY DBCO-amIn 50mg
A copper-free click chemistry reagent; has been used in the synthesis of clickable fluorescent probes
Medchemexpress LLC PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 40:60) | 95.0% | 20kDA to 5.0kDA | 50 MG
PLGA-PEG-MAL (20kDA-5.0kDA, LA:GA ratio 40:60) is a type of poly(lactide-co-glycolide)-block-poly(ethylene glycol) (PLGA-PEG-Mal) nanoparticles. It has a molecular weight range of 20kDA to 5.0kDA and contains a 40:60 ratio of lactic acid (LA) to glycolic acid (GA) molecules.
- It is a nanoparticle.
- For research use only.
- Appearance: solid
- Color: white to off-white
Cayman Chemical ABBV-CLS-484hydrochlorIde 1mg
An inhibitor of PTP1N and PTP2N (IC50s = 2.5 and 1.8 nM, respectively); selective for PTP1N and PTP2N over PTP6N and PTP11N (IC50s = >10 µM for both) but does inhibit PTP9N (IC50 = 15 nM); potentiates IFN-γ-induced decreases in the proliferation of B16-F1 cancer cells at 1 µM; reduces tumor volume in combination with an anti-PD-L1 antibody in a B16-F1 melanoma murine model at 20 mg/kg per day; increases the number of CD8+ effector T cells, NK T cells, neutrophils, and monocytes expressing high levels of IFN-γ-induced genes, as well as increases M1 and decreases M2 macrophages, in the same mouse model a 20 mg/kg per day
ILEX LIFE SCIENCES LLC Cellendes ToLuminate PEG Photogel Photocrosslinkable 1/EA
ToLuminate PEG Photogel Kit photo-crosslinkable hydrogel DESCRIPTION The ToLuminate PEG Photogel Kit manufactured by Cellendes GmbH provides reagents for setting up cell-compatible hydrogels formed by illumination with blue light (365-405 nm) on the basis of the thiol-ene chemistry Its major components are norbornene-modified dextran (N-Dextran) and the thiol-modified cross-linker PEG-Link When the two reagents are combined and illuminated in the presence of LAP (Lithium phenyl-2 4 6-trimethyl benzoyl phosphinate) thiol groups on PEG-Link are activated and form stable thioether bonds with norbornene groups on N-Dextran The components are mixed at physiological pH (pH 7 2) for optimal cell compatibility There is ample time to place the pre-gel solution in any culture dish or container since gelation starts only after illumination Cell adhesion peptides can be covalently attached to N-Dextran to provide a cell-adhesive matrix QUANTITY Up to 4 ml hydrogel
Worthington Biochemical Corporation WORTHINGTON BIOCHEMICAL CORPORATION
NC3988820 TRYPSIN MODIFIED 4X100UG