Protein Modification Reagents
Medchemexpress LLC Methyltetrazine-PEG5-NHS ester | 1802907-92-1 | 97.0% | C24H31N5O9 | 50 MG
Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. This product is for research use only.
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- Purity of 97.0%
Medchemexpress LLC Mal-amido-PEG12-NHS ester | 2101722-60-3 | 98.52% | C38H63N3O19 | 50 MG
Mal-amido-PEG12-NHS ester is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs. These PROTACs are composed of two distinct ligands connected by a linker, one binding to an E3 ubiquitin ligase and the other to a target protein. This mechanism exploits the intracellular ubiquitin-proteasome system to achieve selective degradation of specific target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Achieves selective degradation of target proteins
Medchemexpress LLC Bcn-PEG3-biotin | 1263166-92-2 | 95.0% | 594.76 | C29H46N4O7S | 25 MG
BCN-PEG3-Biotin is a biotinylated, non-cleavable PEG3 antibody-drug conjugate linker containing a BCN strained alkyne for strain-promoted alkyne-azide cycloaddition (SPAAC) click chemistry. It is supplied as an off-white to light yellow solid for research use in bioconjugation, ADC synthesis, and affinity-based labeling.
- Non-cleavable PEG3 linker with BCN for copper-free click chemistry.
- Biotin tag enables streptavidin-based capture and detection.
- Off-white to light yellow solid, soluble in DMSO at 100 mg/mL.
- Purity 95.0% as specified by the manufacturer.
- Store powder at -20°C; prepared solutions stable at -80°C (6 months) or -20°C (1 month).
- Available in milligram quantities including 25 MG.
Medchemexpress LLC Endo-BCN-PEG4-acid | 1881221-47-1 | 99.3% | 441.52 g/mol | C22H35NO8 | 5 MG
endo-BCN-PEG4-acid is a BCN-containing PEG4 linker used for bioconjugation and ADC synthesis. It enables strain-promoted alkyne-azide cycloaddition (SPAAC) click chemistry and provides a terminal carboxylic acid for covalent coupling. Supplied as a high-purity liquid for research applications.
- Cleavable PEG4 linker for bioconjugation.
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC).
- Terminal carboxylic acid for amide coupling.
- High reported purity (99.3%).
- Liquid, colorless to light yellow; store frozen for long-term stability.
- For research use only; not for human therapeutic use.
Medchemexpress LLC Biotin-PEG4-PFP ester | 1334172-58-5 | 96.2% | 657.65 g/mol | C27H36F5N3O8S | 5 MG
Biotin-PEG4-PFP ester is a biotinylated, cleavable PEG-based linker containing a pentafluorophenyl activated ester for efficient coupling to primary amines. It is used in antibody-drug conjugate (ADC) synthesis, PROTAC linker construction, and the biotinylation of proteins or small molecules. The reagent is supplied as a powder and requires low-temperature storage to maintain stability.
- Biotinylated PEG4 spacer with pentafluorophenyl activated ester.
- Suitable for coupling to primary amines in proteins and small molecules.
- Used as an ADC and PROTAC linker or biotinylation reagent.
- High purity and defined storage conditions for stability.
- Available in small milligram quantities for research use.
Medchemexpress LLC Bromoacetamido-PEG4-NHS ester | 1260139-70-5 | 98.69% | C17H27BrN2O9 | 250 MG
Bromoacetamido-PEG4-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands joined by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest. PROTACs function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PROTAC linker
- Suitable for the synthesis of PROTACs
- Intended for research use only
Medchemexpress LLC DBCO-PEG4-DBCO | 2182601-68-7 | 97.4% | 810.93 | C48H50N4O8 | 10 MG
DBCO-PEG4-DBCO is a PEG-based bifunctional linker bearing two dibenzocyclooctyne (DBCO) groups. It is used as a click chemistry reagent for strain-promoted alkyne-azide cycloaddition (SPAAC) and as a PEG linker in PROTAC and antibody-drug conjugate (ADC) synthesis.
- Click chemistry reagent enabling SPAAC with azide-functionalized partners.
- Provides a PEG4 spacer to improve solubility and linker flexibility.
- High solubility in DMSO; manufacturer provides in vitro and in vivo formulation protocols.
- Typical purity around 97.4% and appears as a white to yellow solid.
- Suitable for use in PROTAC and ADC synthesis workflows.
Medchemexpress LLC DNP-PEG4-NHS ester | 858126-78-0 | 96.81% | C21H28N4O12 | 100 MG
DNP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
- Stable for 3 years in pure form at -20°C
- Stable for 6 months in solvent at -80°C
- Stable for 1 month in solvent at -20°C
Medchemexpress LLC Methyltetrazine-PEG4-acid | 1802907-91-0 | 99.8% | C20H28N4O7 | 25 MG
Methyltetrazine-PEG4-acid is a solid laboratory chemical primarily used for the manufacture of substances. It has a molecular weight of 436.46 and typically appears as a purple to purplish-red solid.
- Purity: 99.8% (HPLC)
- Molecular formula: C20H28N4O7
- Stable under recommended storage conditions
- Boiling point/range: 647.6±65.0 °C at 760 mmHg
- Relative density: 1.236 g/cm³
- Recommended storage:
- Powder: -20°C for 3 years; 4°C for 2 years
- In solvent: -80°C for 6 months; -20°C for 1 month
Sigma Aldrich Fine Chemicals Biosciences Collagenase from Clostridium Histolyticum | 9001-12-1 | MFCD00130830 | 5g
Collagenase from Clostridium Histolyticum | 9001-12-1 | MFCD00130830 | 5g
Medchemexpress LLC Bromo-PEG2-C2-azide | 530151-56-5 | MFCD25424115 | 98.7% | 238.08 g·mol⁻1 | C6H12BrN3O2 | 100 MG
Bromo-PEG2-C2-azide is a PEG-based bromo azide linker used as a non-cleavable linker in antibody-drug conjugate (ADC) synthesis and as a PROTAC linker. It contains an azide functional group for click chemistry and a bromoalkyl handle for further functionalization. Molecular formula C6H12BrN3O2; molecular weight 238.08 g·mol⁻1; purity ≥98.7%.
- Contains an azide group for copper-catalyzed and strain-promoted click reactions.
- Provides a bromoalkyl handle for alkylation or substitution reactions.
- Suitable as a non-cleavable linker for ADC synthesis and as a PROTAC linker.
- High purity for reliable synthetic performance.
- Available in small lab quantities for research use.
Medchemexpress LLC Dbco-(PEG2-VC-PAB-MMAE)2 | 2259318-55-1 | 99.2% | 2835.50 g/mol | C149H224N22O32 | 100 MG
DBCO-(PEG2-VC-PAB-MMAE)2 is a drug-linker conjugate and click-chemistry reagent used for preparing antibody-drug conjugates and other azide-based bioconjugates. It combines a DBCO clickable handle, a PEG2 spacer, a Val-Cit protease-cleavable dipeptide, a PAB self-immolative spacer, and an MMAE cytotoxic payload.
- Provides strain-promoted alkyne-azide cycloaddition (SPAAC) reactivity for conjugation to azide-tagged molecules.
- Val-Cit linker enables protease-mediated intracellular release of the MMAE payload.
- Supplied with analytical documentation, including HNMR, RP-HPLC, MS, COA, and SDS.
- Available in multiple pack sizes, including a 100 mg quantity for preparative use.
Medchemexpress LLC Fmoc-NH-(PEG)6-CH2CH2COOH | 882847-34-9 | 99.3% | 575.65 | C30H41NO10 | 500 MG
Fmoc-NH-(PEG)6-CH2CH2COOH is an Fmoc-protected PEG6 propionic acid linker used as a cleavable linker in the synthesis of antibody-drug conjugates (ADCs). It is characterized by high purity, defined molecular properties, and recommended cold storage for stability.
- Cleavable linker for antibody-drug conjugation.
- Fmoc-protected amine functionality for stepwise synthesis.
- PEG6 spacer provides hydrophilicity and flexibility.
- High purity: 99.3%.
- Molecular weight 575.65; formula C30H41NO10.
- Available in multiple sizes: 100 mg, 500 mg, 1 g, 5 g, 10 g.
- Appearance: colorless to light yellow liquid; density 1.202 ± 0.06 g/cm3.
- Storage: -20°C (3 years) or 4°C (2 years) in pure form; in solution -80°C (6 months) or -20°C (1 month).