Protein Modification Reagents
Medchemexpress LLC DSPE-Thiol | 144735-82-0 | MFCD29079392 | 90.0% | 836.19 g·mol⁻¹ | C44H86NO9PS | 5 MG
A thiol-capped distearoyl phosphatidylethanolamine (DSPE) phospholipid for thiol-based conjugation and lipid surface modification. The terminal thiol selectively reacts with maleimide and other thiol-reactive groups, enabling preparation of phospholipid dimers, surface functionalization of liposomes or lipid nanoparticles, and formation of stable thiol-linked conjugates. Supplied as a solid with reported solubility information for DMF and typical purity at 90.0%.
- Thiol-functionalized head group for selective thiol-maleimide conjugation.
- Suitable for liposome surface modification and nanoparticle functionalization.
- Enables preparation of phospholipid dimers and thiol-linked conjugates.
- Soluble in DMF with sonication and gentle heating to aid dissolution.
- Typical purity 90.0% and molecular weight 836.19 g·mol⁻¹.
eMolecules 297162-47-1 | Hydroxy-PEG6-CH2CO2tBu | Broadpharm | MFCD27977498 | 396.477 | C18H36O9 | 98.000 | CC(C)(C)OC(=O)COCCOCCOCCOCCOCCOCCO | 1g | 247403099
Hydroxy-PEG6-CH2CO2tBu | Broadpharm | 297162-47-1 | MFCD27977498 | 396.477 | C18H36O9 | 98.000 | CC(C)(C)OC(=O)COCCOCCOCCOCCOCCOCCO | 1g | 247403099
Chemscene ChemScene | m-PEG24-NHS ester | 250MG | CS-0114287 | 0.98 | 2395839-96-8| MFCD11041155 | 1214.39
ChemScene | m-PEG24-NHS ester | 250MG | CS-0114287 | 0.98 | 2395839-96-8| MFCD11041155 | 1214.39
Medchemexpress LLC m-PEG5-succinimidyl carbonate | 1058691-00-1 | 98.0% | 393.39 g/mol | C16H27NO10 | 25 MG
m-PEG5-succinimidyl carbonate is a monomethoxy polyethylene glycol (PEG) linker with five ethylene glycol units terminated as a succinimidyl carbonate active ester. It is supplied as a reactive linker for conjugation to primary amines in bioconjugation workflows.
- Non-cleavable 5-unit PEG spacer for conjugation.
- Activated succinimidyl carbonate for efficient amine coupling.
- Suitable for ADC and PROTAC synthesis applications.
- Appearance: colorless to light yellow liquid; supplied in small mg quantities for research use.
Medchemexpress LLC Biotin-PEG1-NH2 | 811442-85-0 | 97.0% | 330.45 | C14H26N4O3S | 25 MG
Biotin-PEG1-NH2 is a cleavable, biotinylated one-unit polyethylene glycol (PEG1) linker with a terminal amine used for antibody-drug conjugate (ADC) synthesis and general bioconjugation research. It supplies a short hydrophilic spacer bearing a biotin affinity tag for capture or detection and a primary amine for coupling to payloads.
- Cleavable 1-unit PEG linker.
- Terminal primary amine for conjugation.
- Biotin tag for affinity capture and detection.
- Molecular weight 330.45 g·mol⁻¹.
- Purity 97.0%.
- Supplied as a white to off-white solid.
- Available in 25 MG and larger package sizes.
- Store at 4°C and protect from light; in solvent, -80°C for up to 6 months, -20°C for up to 1 month.
eMolecules Mal-amido-PEG12-TFP ester | 1431295-77-0 | 250MG | Purity: 98%
Broadpharm | Mal-amido-PEG12-TFP ester | 250MG | 1431295-77-0 | MFCD27978401 | MW:82.39
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Medchemexpress LLC Azide-PEG4-VC-PAB-doxorubicin | 99.6% | 1222.25 g/mol | C57H75N9O21 | 5 MG
Azide-PEG4-VC-PAB-doxorubicin is a drug-linker conjugate that links the cytotoxic agent doxorubicin to an azide-PEG4-VC-PAB cleavable linker, intended for use in antibody-drug conjugate (ADC) construction and click-chemistry conjugation (CuAAC and SPAAC).
- Contains an azide functional group for click conjugation.
- Compatible with copper-catalyzed azide-alkyne cycloaddition and strain-promoted alkyne-azide cycloaddition reactions.
- Features a cleavable valine-citrulline-p-aminobenzyl (VC-PAB) linker for intracellular release.
- Supplied as an orange to red solid for convenient handling and storage.
- Purity 99.6% and molecular weight 1222.25 g/mol.
- Available in small-mass pack sizes suitable for research-scale ADC synthesis.
Medchemexpress LLC Tco-peg4-vc-pab-mmae | 2758671-45-1 | 99.3% | 1522.91 | C78H127N11O19 | 1 MG
TCO-PEG4-VC-PAB-MMAE is a drug-linker conjugate used in antibody-drug conjugate (ADC) research and click-chemistry applications; it couples a trans-cyclooctene (TCO) reactive handle to a PEG4-spaced valine-citrulline-para-aminobenzyl (Val-Cit-PAB) cleavable linker and the cytotoxic payload MMAE.
- High purity (99.3%).
- Molecular weight 1522.91 g/mol.
- Chemical formula C78H127N11O19.
- CAS number 2758671-45-1.
- Suitable for iEDDA click chemistry with tetrazine reagents.
- Intended for ADC synthesis and conjugation research.
- Store at -20°C and protect from light; in solvent store at -80°C up to 6 months or -20°C up to 1 month.
- Available in small research pack sizes (e.g., 1 MG).
eMolecules Benzyl-PEG4-CH2CO2tBu | 1443467-88-6 | MFCD28122956 | 1g
Broadpharm | Benzyl-PEG4-CH2CO2tBu | 1g | 254745474 | BP-22262 | 97.000 | 1443467-88-6 | MFCD28122956 | 354.443 | C19H30O6
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eMolecules S-acetyl-PEG3-alcohol | 153870-20-3 | MFCD22574787 | 1g
Broadpharm | S-acetyl-PEG3-alcohol | 1g | 137364442 | BP-20945 | 98.000 | 153870-20-3 | MFCD22574787 | 208.270 | C8H16O4S
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![eMolecules Bromoacetamido-PEG4-azide | Broadpharm |383.243 | C12H23BrN4O5 | 98.000 | BrCC(=O)NCCOCCOCCOCCOCCN=[N+]=[N-] | 100mg | 713699743](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502510912.JPG-250.jpg)
eMolecules Bromoacetamido-PEG4-azide | Broadpharm |383.243 | C12H23BrN4O5 | 98.000 | BrCC(=O)NCCOCCOCCOCCOCCN=[N+]=[N-] | 100mg | 713699743
Bromoacetamido-PEG4-azide | Broadpharm |383.243 | C12H23BrN4O5 | 98.000 | BrCC(=O)NCCOCCOCCOCCOCCN=[N+]=[N-] | 100mg | 713699743
Medchemexpress LLC Biotin-PEG4-hydrazide | 756525-97-0 | 99.9% | C21H39N5O7S | 100 MG
Biotin-PEG4-hydrazide is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Biotin-labeled
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Enables selective degradation of target proteins via the intracellular ubiquitin-proteasome system
Medchemexpress LLC 4-Arm PEG-SCM MW 10 1g
4-Arm PEG-SCM (MW 10000) is a multi-arm PEG derivative that can be used for peptide modification and drug delivery[1]
AURORA BIOLABS LLC TR-FRET Cereblon-4C Binding Assay Kit,384 rxn
E3 ubiquitin ligases are enzymes that catalyze the final step of the ubiquitination process and play essential roles in targeted protein degradation. Cereblon (CRBN) is the substrate-recognition component of the CRBN/DDB1/CUL4A/RBX1 E3 ubiquitin ligase complex and is widely used in PROTAC (Proteolysis-Targeting Chimera) drug discovery for targeted protein degradation applications. The TR-FRET Cereblon-4C Binding Assay Kit is designed to quantitatively measure the binding interaction between CRBN and its ligands. The assay includes Tag1-CRBN-4C complex, terbium-labeled anti-Tag1 antibody, and fluorescently labeled thalidomide ligand. Binding of CRBN to thalidomide generates a fluorescence resonance energy transfer (FRET) signal detected by measuring fluorescence emission at 665 nm and 620 nm. Compounds that compete with thalidomide for CRBN binding reduce the HTRF signal, enabling evaluation of CRBN-targeting molecules for drug discovery and PROTAC research applications.