Protein Modification Reagents
Medchemexpress LLC Dspe-peg-biotin, MW 2000 | 385437-57-0 | 99.9% | 25 MG
DSPE-PEG-Biotin, MW 2000 is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein. They exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based linker
- Facilitates PROTAC synthesis
- Targets proteins for degradation
- Utilizes the ubiquitin-proteasome system
eMolecules 2055041-41-1 | HN-(PEG4-CH2CH2COOtBu)2 | Acrotein ChemBio Inc. | MFCD29912666 | 625.797 | C30H59NO12 | 97.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCNCCOCCOCCOCCOCCC(=O)OC(C)(C)C | 0.5g | 518518368
HN-(PEG4-CH2CH2COOtBu)2 | Acrotein ChemBio Inc. | 2055041-41-1 | MFCD29912666 | 625.797 | C30H59NO12 | 97.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCNCCOCCOCCOCCOCCC(=O)OC(C)(C)C | 0.5g | 518518368
Ambeed 1 9HFluoren9yl 3oxo2 7 10 13 1
1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azanonadecan-19-oic acid, 557756-85-1, 98%
Medchemexpress LLC Biotin-PEG4-PFP ester | 1334172-58-5 | MFCD13184979 | 96.2% | 657.65 | C27H36F5N3O8S | 50 MG
Biotin-PEG4-PFP ester is an activated biotin linker containing a four-unit polyethylene glycol (PEG4) spacer and a pentafluorophenyl (PFP) ester leaving group. It is designed for efficient amine coupling and biotin tagging in bioconjugation workflows such as ADC and PROTAC synthesis.
- Cleavable PEG4 spacer provides flexibility and solubility
- PFP activated ester enables rapid coupling to primary amines
- Biotin tag allows affinity capture and detection
- Suitable for antibody-drug conjugate and probe labeling workflows
- Stable as a powder at -20°C for extended storage
eMolecules 868594-52-9 | Fmoc-nh-peg8-ch2cooh | Combi-Blocks | MFCD27635163 | 649.734 | C33H47NO12 | 95.000 | OC(=O)COCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 5g | 457919886
Fmoc-nh-peg8-ch2cooh | Combi-Blocks | 868594-52-9 | MFCD27635163 | 649.734 | C33H47NO12 | 95.000 | OC(=O)COCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 5g | 457919886
Medchemexpress LLC Dbco-peg4-mmaf | 2360411-65-8 | 99.8% | 1266.56 g·mol⁻¹ | C69H99N7O15 | 5 MG
DBCO-PEG4-MMAF is a drug-linker conjugate used in antibody-drug conjugate research. It contains a dibenzocyclooctyne (DBCO) reactive group connected via a four-unit polyethylene glycol (PEG4) linker to the tubulin inhibitor MMAF, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) for bioconjugation.
- Contains DBCO reactive group for SPAAC click chemistry.
- PEG4 spacer provides flexibility and improved solubility.
- Includes MMAF payload, a potent tubulin polymerization inhibitor.
- High purity and provided as a solid, white to off-white powder.
- Available in small research pack sizes suitable for conjugation workflows.
Medchemexpress LLC N-succinimidyl 4,7,10,13-tetraoxatetradecanoate | 622405-78-1 | MFCD11041112 | 95.0% | 333.33 g/mol | C14H23NO8 | 5G
m-PEG4-NHS ester is a monomethyl-capped polyethylene glycol (PEG4) reagent terminating in an N-hydroxysuccinimide (NHS) ester. It is used as an amine-reactive PEGylation linker and as a spacer in PROTAC and bioconjugation chemistry, enabling attachment of a PEG4 spacer to primary amines on small molecules, peptides, or proteins. CAS 622405-78-1; molecular weight 333.33 g/mol.
Apexbio Technology LLC Cy5.5 alkyne (non-sulfonated) 5mg
Cy5 5 alkyne non-sulfonated is a near-infrared fluorescent cyanine derivative equipped with an alkyne functional group for click chemistry applications Through copper-catalyzed azide-alkyne cycloaddition (CuAAC) it forms covalent conjugates with azide-containing biomolecules metabolites or small-molecule ligands Cy5 5 alkyne non-sulfonated is primarily soluble in organic solvents aqueous solutions containing organic co-solvent such as DMSO may be used during conjugation Based on these chemical properties Cy5 5 alkyne non-sulfonated holds research potential in labeling nucleic acids peptides proteins lipids and other biomolecules for biomedical imaging tissue distribution evaluation and related pharmaceutical research applications
Medchemexpress LLC 2-amino-n-(14-azido-2,5-dioxo-9,12-dioxa-3,6-diazatetradecyl)acetamide | 2222277-20-3 | 95.0% | 345.35 g/mol | C12H23N7O5 | 1 ML
Gly-Gly-Gly-PEG2-azide is an azide-functionalized peptide-PEG linker supplied as a ready-to-use solution (10 mM in DMSO, 1 mL) or as a solid. It is intended for use in antibody-drug conjugate synthesis, bioconjugation, and related chemical biology applications.
- Azide-functionalized peptide-PEG2 linker for bioconjugation.
- Available as 10 mM solution in DMSO (1 mL) or solid forms.
- Used for antibody-drug conjugate synthesis and related chemistry.
- Characterized by CAS 2222277-20-3 and molecular weight 345.35 g/mol.
Medchemexpress LLC DiSulfo-Cy5 alkyne | 1617497-19-4 | C35H40N3NaO7S2 | 1 MG
DiSulfo-Cy5 alkyne is a fluorescent dye that can be used as a click chemistry reagent.
- Fluorescent dye
- Click chemistry reagent
Medchemexpress LLC Bis-propargyl-PEG8 5mg | 1092554-87-4 | 5 MG
Bis-propargyl-PEG8 is a PEG-based bifunctional linker with two terminal propargyl (alkyne) groups used as a click-chemistry reagent for bioconjugation and PROTAC synthesis.
- Contains two terminal propargyl (alkyne) groups for CuAAC reactions.
- Suitable for copper-catalyzed azide-alkyne cycloaddition (click chemistry).
- PEG8 spacer provides hydrophilicity and flexible linkage.
- Molecular formula C22H38O9 and molecular weight 446.53 g·mol⁻¹.
- Available in small research quantities such as 5 MG.
![eMolecules 1603854-42-7 | Biotin-PEG4-Amide | Broadpharm490.620 | C21H38N4O7S | 95.000 | NC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 50mg | 573896512](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502459584.PNG-250.jpg)
eMolecules 1603854-42-7 | Biotin-PEG4-Amide | Broadpharm490.620 | C21H38N4O7S | 95.000 | NC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 50mg | 573896512
Biotin-PEG4-Amide | Broadpharm | 1603854-42-7490.620 | C21H38N4O7S | 95.000 | NC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 50mg | 573896512
Medchemexpress LLC Propargyl-PEG4-CH2COOH | 1429934-37-1 | >97.0% | 290.31 | 25 MG
Propargyl-PEG4-CH2COOH is a PEG-based PROTAC linker used in the synthesis of PROTACs. It acts as a click chemistry reagent, featuring an Alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Azide-containing molecules. PROTACs, composed of two ligands linked together, target an E3 ubiquitin ligase and a specific protein, thereby utilizing the intracellular ubiquitin-proteasome system for selective protein degradation.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent
- Features Alkyne group for CuAAc
- Enables selective protein degradation via ubiquitin-proteasome system
Medchemexpress LLC Dde Biotin-PEG4-DBCO | 1807512-43-1 | 96.2% | C47H61N5O9S | 25 MG
Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker used in the synthesis of PROTACs. This click chemistry reagent contains a DBCO group that undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC)
- Reacts with azide-containing molecules