Protein Modification Reagents
Medchemexpress LLC Biotin-PEG4-hydrazide | 756525-97-0 | 99.9% | C21H39N5O7S | 100 MG
Biotin-PEG4-hydrazide is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Biotin-labeled
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Enables selective degradation of target proteins via the intracellular ubiquitin-proteasome system
Medchemexpress LLC Poly(lactic-co-glycolic acid)-block-poly(ethylene glycol)-maleimide | 95.0% | PLGA 20 kDa; PEG 5.0 kDa | 10 MG
PLGA-PEG-MAL is a thiol-reactive block copolymer comprised of poly(lactic-co-glycolic acid) and polyethylene glycol terminated with a maleimide group. The product is specified with a ~20 kDa PLGA block and a ~5.0 kDa PEG block (LA:GA 40:60) and is intended for research use in nanoparticle formulation, surface functionalization, and conjugation of thiol-containing ligands.
- Polymeric block copolymer with maleimide functional group for thiol conjugation.
- PLGA block ~20 kDa; PEG block ~5.0 kDa, LA:GA ratio 40:60.
- Suitable for nanoparticle formulation and drug delivery research.
- Soluble in DMSO for formulation and conjugation workflows.
- Reported purity approximately 95.0%.
- Supplied in small research quantities (for example, 10 mg packs).
Medchemexpress LLC 4-Arm PEG-SCM MW 10 1g
4-Arm PEG-SCM (MW 10000) is a multi-arm PEG derivative that can be used for peptide modification and drug delivery[1]
Medchemexpress LLC DMG-PEG-NHS, MW 2000 | 95.0% | 2000 | 5 MG
DMG-PEG-NHS, MW 2000 is a compound composed of Myristic acid (HY-N2041) and PEG linked by an amide bond, with NHS as an active ester group attached to the end of the PEG chain.
- Used for protein/biomolecule modification.
- Supports gene delivery.
- Applicable in biosensor applications.
eMolecules 1807518-76-8 | Fluorescein-PEG4-Acid | Broadpharm | MFCD28505585 | 654.690 | C32H34N2O11S | 0.000 | OC(=O)CCOCCOCCOCCOCCNC(=S)Nc1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc12 | 100mg | 138794151
Fluorescein-PEG4-Acid | Broadpharm | 1807518-76-8 | MFCD28505585 | 654.690 | C32H34N2O11S | 0.000 | OC(=O)CCOCCOCCOCCOCCNC(=S)Nc1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc12 | 100mg | 138794151
Medchemexpress LLC Dspe-peg-biotin | 385437-57-0 | 99.93% | 100 MG
DSPE-PEG-Biotin, MW 2000 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based PROTAC linker.
- Used in the synthesis of PROTACs.
- Can be dissolved in DMSO and H2O for in vitro experiments.
- Multiple dissolution protocols are available for in vivo experiments using various co-solvents like DMSO, PEG300, Tween-80, Saline, SBE-β-CD, and Corn Oil.
Medchemexpress LLC Bromoacetamido-PEG5-DOTA | 2353410-19-0 | 98.0% | C30H55BrN6O13 | 50 MG
Bromoacetamido-PEG5-DOTA is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. These compounds employ two distinct ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other a target protein. PROTACs leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins. This product appears as a white to off-white oil.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Appears as a white to off-white oil
- For research use only
Gene Tools LLC Endo-Porter PEG, Safe Cytosolic Delivery, Low Toxicity, 1 mL
Endo-Porter PEG is an innovative amphiphilic peptide reagent designed for safe and efficient cytosolic delivery of macromolecules into cultured cells. Its unique endocytosis-mediated mechanism ensures effective cargo escape from endosomes while minimizing toxicity. Unlike other methods, it requires no cargo pre-incubation and works optimally even in 10% serum. This simplifies protocols and offers reduced toxicity, making it a go-to choice for researchers in cellular delivery applications.
Avanti Polar Lipids DSPE-PEG(5000) Amine | 474922-26-4 | 10mg
DSPE-PEG(5000) Amine | Purity: 99% | Mol Wt: 5900.029 | 474922-26-4 | 10mg
Medchemexpress LLC Azide-PEG-amine (MW 2000) | 95.0% | 100 MG
Azide-PEG-amine (MW 2000) is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent.
- Contains an azide group.
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules.
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Medchemexpress LLC Mal-PEG2-Val-Cit-PABA-PNP | 1345681-52-8 | 96.8% | 755.73 | C34H41N7O13 | 5 MG
Mal-PEG2-Val-Cit-PABA-PNP is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). It contains a maleimide reactive group, a two-unit polyethylene glycol spacer, and a protease-sensitive Val-Cit-PABA peptide spacer that enables payload release in target cells.
- cleavable linker for ADC synthesis
- contains maleimide (Mal) reactive group
- two-unit PEG spacer (PEG2) provides solubility and flexibility
- val-cit-paba sequence is protease sensitive for intracellular release
- para-nitrophenyl (PNP) activating group for conjugation chemistry
- solid, white to off-white appearance; high purity
- available in multiple sizes and requires protection from light and storage under inert gas