Protein Modification Reagents
Cayman Chemical PEG 2000-C-DMG 1mg
A PEGylated derivative of DMG; has been used in combination with other lipids in the formation of LNPs for the delivery of siRNA; LNPs containing C-DMG-mPEG(2000) and encapsulating siRNA targeting the genes encoding PD-L1 and PD-L2 decrease PD-L1 and PD-L2 levels in monocyte-derived dendritic cells
Medchemexpress LLC DSPE-PEG-folate | 90.0% | 2000 (Average) | 5 MG
DSPE-PEG-folate (average MW 2000) is a PEGylated lipid conjugate in which a DSPE lipid is linked to polyethylene glycol terminating in folate. Supplied as a solid powder for research use, it is used to introduce folate targeting moieties onto liposomes, micelles, and nanoparticle surfaces to enable receptor-mediated delivery to folate receptor-expressing cells. Typical storage: powder at -20°C; in solvent store at -80°C for long-term stability.
- Provides folate-mediated targeting to folate receptor-expressing cells.
- Suitable for incorporation into liposomes, micelles, and nanoparticle surfaces.
- Average molecular weight approximately 2000 Da.
- Supplied as a solid powder for laboratory research use.
- Purity approximately 90.0% as provided by the manufacturer.
- Storage recommendations included for powder and in-solution conditions.
Medchemexpress LLC (S,R,S)-AHPC-PEG5-COOH | 2172820-14-1 | 99.8% | 1 ML
(S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 5-unit PEG linker used in PROTAC technology. This product is for research use only and not sold to patients.
- Incorporates an (S,R,S)-AHPC-based VHL ligand
- Features a 5-unit PEG linker
- Utilized in PROTAC technology
- Recruits VHL protein, a substrate recognition subunit of Cullin RING E3 ubiquitin ligase complexes
- Induces ubiquitination and subsequent proteasomal degradation of target proteins
Medchemexpress LLC Phenol-amido-C1-PEG3-N3 | 1096439-18-7 | 99.9% | 10 MG
Phenol-amido-C1-PEG3-N3 (PROTAC Linker 21) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group that facilitates copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules possessing Alkyne groups. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Azide group
- Facilitates copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules possessing alkyne groups
- Engages in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups
Medchemexpress LLC Cholesterol-PEG-maleimide | 95.1% | 2000 (average) | 25 MG
Cholesterol-PEG-maleimide (MW 2000) is a cholesterol-terminated polyethylene glycol derivative bearing a terminal maleimide for thiol-specific conjugation. Supplied as a solid, it is intended for incorporation into liposomes and nanoparticles to provide steric stabilization and enable covalent attachment of thiol-containing ligands for surface functionalization and targeted delivery applications.
- Provides steric stabilization to liposomes and nanoparticles.
- Maleimide group enables covalent conjugation to thiols via thioether bond.
- Average PEG molecular weight 2000; polydisperse polymeric material.
- High purity (~95.1%) suitable for formulation and conjugation studies.
- Soluble in DMSO up to 100 mg/mL; freshly opened DMSO recommended.
- Powder storage: -20°C; in solvent storage recommendations included.
Medchemexpress LLC Cyanine 5-polyethylene glycol3-TCO | 99.2% | 845.55 | C49H69ClN4O6 | 10 MG
Cy5-PEG3-TCO is a Cy5-derived fluorescent probe bearing a three-unit polyethylene glycol (PEG3) spacer and a trans-cyclooctene (TCO) functional group. It is designed for bioorthogonal labeling via inverse electron-demand Diels-Alder (iEDDA) reactions with tetrazine-functionalized partners and is supplied as a solid for laboratory use.
- Cyanine 5 fluorescent core for near-infrared imaging
- PEG3 spacer improves solubility and reduces steric hindrance
- TCO group enables rapid iEDDA click chemistry with tetrazines
- High purity (99.2%) suitable for labeling applications
- Soluble in DMSO (≈16.67 mg/mL); may require ultrasonic
- Stored sealed away from moisture and light at 4°C (solid)
Medchemexpress LLC Dbco-(PEG2-VC-PAB-MMAE)2 | 2259318-55-1 | 99.2% | 2,835.50 g/mol | C149H224N22O32 | 50 MG
DBCO-(PEG2-VC-PAB-MMAE)2 is a drug-linker conjugate for antibody-drug conjugate (ADC) research that combines a DBCO reactive group with a cleavable valine-citrulline linker, a p-aminobenzyl self-immolative spacer, and dual MMAE payloads. It is supplied as a purified powder for use in bio-conjugation via strain-promoted alkyne-azide cycloaddition (SPAAC).
- Provides a DBCO reactive group for copper-free click chemistry (SPAAC).
- Includes a PEG2 spacer for improved solubility and flexibility.
- Features a valine-citrulline cleavable linker with a p-aminobenzyl self-immolative spacer.
- Contains two MMAE payloads for potent cytotoxic delivery.
- High purity, typically 99.2%.
- Supplied as a powder suitable for ADC construction and conjugation.
Medchemexpress LLC Methyl-PEG4 N-hydroxysuccinimide ester | 622405-78-1 | MFCD11041112 | 95.0% | 333.33 | C14H23NO8 | 1G
M-PEG4-NHS ester is a methyl-terminated polyethylene glycol (PEG) linker bearing an N-hydroxysuccinimide (NHS) ester. It is intended for bioconjugation and medicinal chemistry applications, including PROTAC synthesis and amine labeling, where an amine-reactive spacer that improves solubility and enables stable amide bond formation is required.
- Provides an NHS ester for efficient coupling to primary amines.
- Methyl-terminated PEG4 spacer improves solubility and reduces steric hindrance.
- Molecular weight 333.33 and formula C14H23NO8.
- Typical purity 95.0% suitable for synthetic applications.
- Available in multiple pack sizes, including 1 g.
Medchemexpress LLC DSPE-PEG-COOH | No CAS number listed for this product (HY-W591461). | No MFCD number listed for this product (HY-W591461). | 100.0% | 2000 (average) | No chemical formula listed for this product (polymeric PEG; variable repeat unit). | 25 MG
DSPE-PEG-COOH, MW 2000 is a PEGylated phospholipid used to formulate liposomes and lipid nanoparticles. It is supplied as a white to off-white solid and features a terminal carboxylic acid that can be activated to form stable amide bonds with primary amines for surface conjugation. Typical storage is -20°C, sealed, away from moisture.
- Terminal carboxylic acid for amide bond conjugation.
- Suitable for liposome and lipid nanoparticle formulation.
- White to off-white solid for easy handling and weighing.
- Available in small research pack sizes for lab use.
- High purity suitable for research use (purity ≥99.9%).
BEZWADA BIOMEDICAL LLC PEG Diacrylate, MW 6000, 5.0 GM
Acrylate/methacrylate end functionalization enables crosslinking. Polymers used in drug delivery and various biomedical applications
![eMolecules Broadpharm / endo-BCN-PEG4-Val-Cit-PAB-MMAF / 5mg / 779524272 / BP-29649 / 98.000 / / [null] / 1560.937 / C80H125N11O20](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502473537.JPG-250.jpg)
eMolecules Broadpharm / endo-BCN-PEG4-Val-Cit-PAB-MMAF / 5mg / 779524272 / BP-29649 / 98.000 / / [null] / 1560.937 / C80H125N11O20
Broadpharm / endo-BCN-PEG4-Val-Cit-PAB-MMAF / 5mg / 779524272 / BP-29649 / 98.000 / / [null] / 1560.937 / C80H125N11O20
![Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000] (sodium salt) | 474922-20-8 | 100.0% | 2000 g/mol (average) | C134H267N2O57P | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000284570.png-250.jpg)
Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000] (sodium salt) | 474922-20-8 | 100.0% | 2000 g/mol (average) | C134H267N2O57P | 5 MG
DSPE-PEG-COOH (MW 2000) is a PEGylated phospholipid used to formulate liposomes and lipid nanoparticles for research applications. The DSPE moiety anchors in lipid bilayers while the PEG chain provides steric stabilization; the terminal carboxylic acid enables covalent conjugation to primary amines for surface functionalization.
- Used to prepare liposomes and lipid nanoparticles for drug delivery research.
- Terminal carboxylic acid enables amide bond formation with primary amines.
- PEG2000 chain improves colloidal stability and circulation time.
- White to off-white solid, suitable for storage and handling in laboratory settings.
- Available in small pack sizes suitable for research-scale experiments.
ILEX LIFE SCIENCES LLC 3-D LIFE PEG-LINK 3 X 200 UL
3-D Life PEG-Link, non-cell-degradable thiol-modified polyethylene glycol, hydrogel crosslinker component (3 x 200 ul). INTRO: 3-D Life technology, manufactured in Germany by Cellendes GmbH, is an integrated system for generation of hydrogels used in 3D cell culture. 3-D Life represents the most flexible system for biomimetic hydrogel design. DESCRIPTION: 3-D Life PEG-Link consists of polyethylene glycol carrying a thiol at each end. When combined with the 3-D Life Hydrogel polymers, thiol groups on PEG-Link form stable thioether bonds with the thiol-reactive groups on the polymers, resulting in formation of the hydrogel. PEG-Link can be used with 3-D Life functionalized polymers Mal-PVA, Mal-Dextran, SG-PVA and SG-Dextran. APPLICATION: 3-D Life PEG-Link is used together with thiol-reactive polymers of the 3-D Life system to establish 3-D cell cultures. QUANTITY: When used with polymers of the 3-D Life Hydrogel system up to 6 ml hydrogel can be generated, depending on gel stiffness.