General Cell Based Assays
Cayman Chemical BIlIrubIn ConjugatesodIM10mg
A stable, water-soluble ditaurate derivative of bilirubin meant to mimic endogenous bilirubin glucuronide derivatives; exhibits anti-oxidant and antimutagenic effects
Eurofins Discoverx PathHunter Mouse MC4R β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Mouse MC4R β-Arrestin Stable Cell Pool Assay (CHO-K1) contains a stable engineered cell pool used to measure mMC4R (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell pool vials, all required culture reagents for maintaining the cells in continuous culture, and detection reagents for running the assay.
Eurofins Discoverx PathHunter Flash Detection Kit, 125 (10 plates), 1,000/4,000 dp (96-well/384-well). (93-0247)
The PathHunter Flash Detection Kit is a detection kit intended for use with PathHunter cell lines or with custom cell lines made using ProLabel/PK expression vectors. This kit will provide a brighter signal with shorter kinetics than the PathHunter Detection Kit, at the cost of a shorter half life. It can be substituted in and used with any cell line that specifies use of the PathHunter Detection kit. This kit contains lysis buffer and EFC substrate to allow for detection of EFC levels in the assayed cells. This kit contains all components required to assay 10 plates (96/384-well). For detailed product information, User manual and COA, visit www.discoverx.com/products/reagents/detection-kit-93-0247.
Cayman Chemical EstradIol 17 DGlucuronIde 50mg
An estrogen metabolite that acts as a substrate of MRP2 (Km = 75 µM), and through MRP2-mediated transport, functions as a cholestatic agent, decreasing bile flow
Eurofins Discoverx PathHunter Darbepoetin Alfa Bioassay Kit, 10pl. (93-0965Y3-00020)
The PathHunter Darbepoetin Alfa Bioassay kit provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay assesses erythropoetin or darbepoetin alfa-induced dimerization of EPOR receptors. This product uses EFC technology. The cell line included overexpresses EPOR target protein fused to PK alongside EPOR target protein fused to EA. Upon ligand-induced dimerization of EPOR, detectable EFC signal is produced. Bioassay kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, control agonist, detection reagent, and assay plates. For detailed product information, User manual and COA, visit www.discoverx.com/bioassay.
Meso Scale Discovery U-PLEX Human MCP-3 Assay, Single-Analyte, 96-well plate, LLOD 0.79 pg/mL, Dynamic Range 0.79 - 5000 pg/mL, Uses human serum, plasma, cell culture supernatant
The U-PLEX Human MCP-3 Assay from MESO SCALE DISCOVERY offers a robust solution for the quantitative measurement of human Monocyte Chemoattractant Protein 3 (MCP-3/CCL7). This assay is designed for research applications in immunology and inflammation, providing sensitive detection across a wide dynamic range of human biological samples.
- High quality and ease of use with validated components
- Enables precise quantification of human MCP-3, crucial for inflammatory response
- Validated for diverse human sample types, including serum, plasma, and cell culture supernatant
- Features a low limit of detection at 0.79 pg/mL
- Wide dynamic range of 0.79 - 5,000 pg/mL for various concentrations
- Single-analyte format optimized for dedicated MCP-3 measurement
Eurofins Discoverx PathHunter eXpress GPR45 CHO-K1 β-Arrestin Orphan GPCR Assay, 10-Plate Kit. (93-0374E2ACP1L)
The PathHunter GPR45 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of GPR45 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR45 and EA-tagged β-Arrestin-2. Activation of GPR45 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. This is an orphan receptor without a known ligand. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Abcam Adipogenesis Detection Assay Kit (Colorimetric/Fluorometric)
Adipogenesis Detection Assay Kit (Colorimetric/Fluorometric)
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical LIpoxygenase InhIbItr Screen
Cayman’s Lipoxygenase Inhibitor Screening Assay Kit detects and measures the hydroperoxides produced in the lipoxygenation reaction using a purified LO. The detection reaction is equally sensitive to hydroperoxides at various positions within the fatty acid, and will work with fatty acids of any carbon length. It is thus a general detection method for LO, and can be used to screen libraries of compounds for those which inhibit LO enzymes.Provided in this kit is arachidonate 15-LO purified from soybean, which can be used to screen test compounds. Alternatively, if other purified LOs (provided by the user) are to be used for screening, the included enzyme can be used as a control. Both arachidonic and linoleic acids are included as substrates. The preferred substrate for screening will depend on the LO being tested. It is recommended to use the fatty acid substrate best suited for the LO being tested.
ABclonal Technology HRH3 Rabbit pAb
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system.