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A cell-permeable. Reversible, selective inhibitor of the growth of malignant peripheral nerve sheath tumors (EC50 = 439 nM, 754 nM, and 1.0 μM in S462, SNF96.2, and sMPNST cells).
A cell-permeable compound that reduces glucokinase Km for glucose (EC50 = 120 nM & 350 nM, for human and rat enzyme). Enhances insulin secretion from INS-1 cells upon glucose exposure.
A cell-permeable inhibitor of SKP2-dependent p27Kip1 ubiquitination. Selectively induces the accumulation SCFSKP2 substrates in multiple myeloma RPMI 8226 cells.