Protein Purification
MilliporeSigma™ Calbiochem™ InSolution™ Y-27632
Y-27632A, CAS 146986-50-7, is a cell-permeable, reversible, inhibitor of Rho kinases (Ki = 140 nM for p160ROCK). Enhances survival & cloning efficiency of ESC without affecting their pluripotency.
MilliporeSigma™ Calbiochem™ TOPK/PBK Inhibitor, HI-TOPK-032
A cell-permeable, selective, ATP competitive, reversible inhibitor of T-LAK-cell-originated protein kinase (IC50 = 2 μM).
MilliporeSigma™ Calbiochem™ InSolution™ ATM Kinase Inhibitor
The InSolution™ ATM Kinase Inhibitor controls the biological activity of ATM Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ InSolution™ Cyclopamine, V. californicum
The InSolution™ Cyclopamine, V. californicum controls the biological activity of Sonic Hedgehog signaling pathway. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ PD 150606
A cell-permeable, non-competitive, selective non-peptide calpain inhibitor [Ki = 210 nM for calpain-1 and 370 nM for calpain-2.
MilliporeSigma™ Calbiochem™ Adenosine 3',5'-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt
A potent, cell-permeable, and reversible metabolically-stable cAMP antagonist that inhibits cAMP-dependent protein kinase and shows preference for PKA type I.
MilliporeSigma™ Calbiochem™ Emodin
A cell-permeable, reversible, substrate competitive and potent p56lck tyrosine kinase inhibitor (IC50 = 18.5 μM).
MilliporeSigma™ Calbiochem™ IGF-1R Inhibitor, PPP
The IGF-1R Inhibitor, PPP, also referenced under CAS 477-47-4, controls the biological activity of IGF-1R. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ InSolution™ Q-VD-OPh, Non-O-methylated
InSolution™ Q-VD-OPh, Non-O-methylated, is a cell-permeable, irreversible, broad-spectrum inhibitor of caspases (IC50 = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively).
MilliporeSigma™ Calbiochem™ PKR/PERK Activator, DHBDC
A cell permeable dual activator of protein kinase R (PKR) and protein kinase R like kinase (PERK). Induces the phosphorylation of IκBα and thereby activates NF-κB pathway.
MilliporeSigma™ Calbiochem™ RAD51-Stimulatory Compound-1, RS-1
A cell-permeable sulfonamido-benzamide-based allosteric regulator that stimulates DNA binding and recombinase activities of hRAD51 by locking hRAD51 in an active conformation without affecting its active site ATP hydrolysis.
MilliporeSigma™ Calbiochem™ CXCR4 Antagonist I, AMD3100
The CXCR4 Antagonist I, AMD3100, also referenced under CAS 155148-31-5, controls the biological activity of CXCR4. This small molecule/inhibitor is primarily used for Cell Signaling applications.
MilliporeSigma™ Calbiochem™ α-Synuclein Blocker, ELN484228
A cell-permeable compound that reversibly binds to pocket I of the monomeric α-synuclein (α-syn) and reverses α-syn-induced impairment of phagocytosis in H4 neuroglioma cells.
MilliporeSigma™ Calbiochem™ eEF2K Inhibitor, A-484954
The eEF2K Inhibitor, A-484954, also referenced under CAS 142557-61-7, controls the biological activity of eEF2K Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5
The p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 controls the biological activity of p75NTR. This small molecule/inhibitor is primarily used for Neuroscience applications.