Protein Purification
MilliporeSigma™ Calbiochem™ SNX-482
A peptidyl toxin from venom of African tarantula, Hysterocrates gigas that acts as a high affinity, reversible blocker of Cav2.3 (α1E, R-type) channels (IC50 = 15-30 nM).
MilliporeSigma™ Calbiochem™ Sertraline Hydrochloride
A very potent uptake inhibitor highly selective for serotonin (Ki
MilliporeSigma™ Calbiochem™ CFTR Activator, Cact-A1
A cell-permeable, non-toxic aminopyrazolocarbonitrile compound that acts as a potent, selective, reversible and cAMP-independent activator of CFTR-dependent Cl- channel in airway epithelial cells (EC50
MilliporeSigma™ Calbiochem™ Midkine Inhibitor, iMDK
A cell-permeable imidazothiazolyl-chromenone compound that reduces cellular midkine/MDK protein level in H441 lung adenocarcinoma cells in a dose-dependent manner (by >90% in 48 h at 25nM) via a yet unidentified mechanism
MilliporeSigma™ Calbiochem™ NMD Inhibitor
A cell-permeable inhibitor of nonsense-mediated mRNA decay (NMD) that enhances the stability of premature termination codon mutated p53 mRNA in N417 and HDQP-1 cells.
MilliporeSigma™ Calbiochem™ TLR1/TLR2 Antagonist, CU-CPT22
A cell-permeable benzotropolone compound that competes against Pam3 CSK4
MilliporeSigma™ Calbiochem™ Luciferase Inhibitor I
The Luciferase Inhibitor I, also referenced under CAS 352341-26-5, controls the biological activity of Luciferase.
MilliporeSigma™ Calbiochem™ PPARβ/δ Antagonist, GSK3787
The PPARβ/δAntagonist II, PT-S58, also referenced under CAS 188591-46-0, controls the biological activity of PPARβ/δ. This small molecule/inhibitor is primarily used for Biochemicals applications.
MilliporeSigma™ Calbiochem™ TCPOBOP
The most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents.
MilliporeSigma™ Calbiochem™ Thapsigargin
Thapsigargin, CAS 67526-95-8, is a cell-permeable, tumor-promoting sesquiterpene lactone that releases calcium by non-competitvley inhibiting endoplasmic reticular Ca2+-ATPase (IC50 = 4-13 nM).
MilliporeSigma™ Calbiochem™ Castanospermine, Castanospermum australe
Plant alkaloid inhibitor of several β-glucosidases and α-glucosidases, including those involved in N-linked processing of glycoproteins.
MilliporeSigma™ Calbiochem™ Piperlongumine
A cell-permeable, orally bioavailable natural product isolated from the plant species, Piper longum L, which selectively induces cell death in cancer cells that express both wild-type and mutant p53.
MilliporeSigma™ Calbiochem™ QX-314
A quaternary lidocaine derivative, permanently charged, and lipophobic.
MilliporeSigma™ Calbiochem™ MEK1/2 Inhibitor III
The MEK1/2 Inhibitor III, also referenced under CAS 391210-10-9, controls the biological activity of MEK1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ MRP1 Inhibitor II, Reversan
The MRP1 Inhibitor II, Reversan controls the biological activity of MRP1. This small molecule/inhibitor is primarily used for Cell Structure applications.