Protease Inhibitors and Phosphatase Inhibitors
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MilliporeSigma™ Calbiochem™ Prostaglandin EP2 Receptor Antagonist, TG6-10-1
A cell-permeable, 3-acryl-acrylamide derivative that acts as a highly potent, selective, and competitive antagonist of prostaglandin E2 receptor (EP2, Kb =
MilliporeSigma™ Calbiochem™ (+)-Blebbistatin
The inactive enantiomer of (±)-Blebbistatin.
MilliporeSigma™ Calbiochem™ Calpastatin Peptide
A 27-amino acid, cell-permeable peptide encoded by exon 1B of human calpastatin that acts as a potent inhibitor of calpain I and calpain II (IC50 = 20 nM for purified rabbit calpain II).
MilliporeSigma™ Calbiochem™ ALLM
Cell permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM).
MilliporeSigma™ Calbiochem™ InSolution™Bestatin, Hydrochloride
A metalloprotease inhibitor. Reversibly binds to cell surfaces and competitively inhibits surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase.
MilliporeSigma™ Calbiochem™ Palmitoylethanolamide
Palmitoylethanolamide is an endogenous lipid that acts as a selective agonist for GPR55 receptors. Producing robust anti-inflammatory actions by activating PPARα (EC50 = 3 μM).
MilliporeSigma™ Calbiochem™ BAY 41-2272
A cell-permeable pyrazolopyridinylpyrimidine compound that acts as a selective and potent stimulator of soluble guanylate cyclase (effective dose ∽ 0.1nM to 100μM using recombinant soluble guanylate cyclase).
MilliporeSigma™ Calbiochem™ InSolution™ Bcl-2 Inhibitor VI, ABT-737
A 25 mM (5 mg/246 μL) solution of Bcl-2 Inhibitor VI, ABT-737 in DMSO.
MilliporeSigma™ Calbiochem™ TGF-β RI Kinase Inhibitor IV
TGF-β RI Kinase Inhibitor IV, CAS 909910-43-6, is a cell-permeable, selective inhibitor of ALK-4/5/7-mediated signaling (IC50 = 45, 12, and 7.5 nM, respectively).
MilliporeSigma™ Calbiochem™ TGF-β RI Kinase Inhibitor II
TGF-β RI Kinase Inhibitor II, CAS 446859-33-2, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of TGF-β R1 kinase (IC50 = 23 nM and 4 nM for ALK5 binding & auto-phosphorylation).
MilliporeSigma™ Calbiochem™ TNAP Inhibitor
The TNAP Inhibitor, also referenced under CAS 496014-13-2, controls the biological activity of TNAP. This small molecule/inhibitor is primarily used for Cell Structure applications.
MilliporeSigma™ Calbiochem™ AMPK Activator
The AMPK Activator, also referenced under CAS 849727-81-7, modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
MilliporeSigma™ Calbiochem™ Nα-Tosyl-Phe Chloromethyl Ketone
Irreversible inhibitor of chymotrypsin
MilliporeSigma™ Calbiochem™ U0126
U0126, CAS 109511-58-2, is a potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK.