Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ SB 202190, Hydrochloride
A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190.
MilliporeSigma™ Calbiochem™ Cytoplasmic Dynein Inhibitor, Ciliobrevin D
Ciliobrevin D is a cell-permeable, reversible, and specific blocker of AAA+ ATPase motor cytoplasmic dynein. Disrupts spindle pole focusing and kinetochore-microtubule attachment (≈10 to 40 μM).
MilliporeSigma™ Calbiochem™ Val-boroPro
An orally available amino boronic acid dipeptide with antihyperglycemic and anticancer properties
MilliporeSigma™ Calbiochem™ 5-Fluoro-2'-deoxyuridine
Experimental anticancer agent shown to have activity against a variety of malignant neoplasms, including mouse mammary tumors and colorectal carcinomas.
MilliporeSigma™ Calbiochem™ D-erythro-Sphingosine, N,N-Dimethyl-
A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC50 = 12 μM) and stimulates Src kinase activity.
MilliporeSigma™ Calbiochem™ Sodium Orthovanadate
A broad spectrum potent inhibitor of protein tyrosine phosphatases.
MilliporeSigma™ Calbiochem™ Windorphen
A cell-permeable, selective inhibitor p300 histone acetytransferase (IC50 = 4.2μM)
MilliporeSigma™ Calbiochem™ Pancuronium Dibromide
A highly potent competitive antagonist selective for nAChRs (IC50
MilliporeSigma™ Calbiochem™ Hydroxyurea
Anti-neoplastic agent that blocks DNA replication by inhibiting ribonucleotide reductase.
MilliporeSigma™ Calbiochem™ Bcl-2 Binding Peptide, Cell-Permeable, Negative Control
A cell-permeable, mutated cpm-1285 peptide analog (Leu151 replaced by Ala) that does not induce apoptosis and displays nearly 15-fold reduction in Bcl-2 binding.
MilliporeSigma™ Calbiochem™ MMP-2/MMP-9 Inhibitor IV
The MMP-2/MMP-9 Inhibitor IV, also referenced under CAS 292605-14-2, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ Granzyme B Inhibitor I
The Granzyme B Inhibitor I controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ SHIP2 Inhibitor II, CPDA
A cell-permeable aminopyridine acetamide based compound that acts as an inhibitor of SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) that can overcome insulin resistance in 3T3-L1 adipocytes.
MilliporeSigma™ Calbiochem™ Caspase Inhibitor VI
Z-VAD-FMK, CAS 161401-82-7, is an irreversible pan caspase inhibitor. Does not require pretreatment with esterase for in vitro studies.
MilliporeSigma™ Calbiochem™ Nifedipine
Relatively selective blocker of L-type Ca2+ channels.