Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ PFKFB3 Inhibitor, 3PO
PFKFB3 Inhibitor, 3PO, is a cell-permeable, selective inhibitor of PFK-2 (6-phosphofructo-2-Kinase) activity.
MilliporeSigma™ Calbiochem™ MMP-9 Inhibitor I
MMP-9 Inhibitor I, CAS 1177749-58-4, is a cell-permeable, potent, and reversible MMP-9 Inhibitor (IC50 = 5 nM). At high concentration inhibits MMP-1 (IC50 = 1.05 μM) & MMP-13 (IC50 = 113 nM).
MilliporeSigma™ Calbiochem™ Necrosis Inhibitor, IM-54
The Necrosis Inhibitor, IM-54, also referenced under CAS 861891-50-1, selectively blocks oxidative stress-induced necrotic cell death. This small molecule/inhibitor is primarily used for Cancer applications.
MilliporeSigma™ Calbiochem™ CDC25 Phosphatase Inhibitor I, BN82002
The CDC25 Phosphatase Inhibitor I, BN82002, also referenced under CAS 396073-89-5, controls the biological activity of CDC25 Phosphatase. This small molecule/inhibitor is primarily used for Phosphorylation and Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ PKG Iα Inhibitor, Cell-Permeable
The PKG Iα Inhibitor, Cell-Permeable controls the biological activity of PKG Iα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ SKP2 E3 Ligase Inhibitor I, C1
A cell-permeable rhodanine compound that upregulates cellular p21Cip1/Waf1 and p27Kip1 protein levels (10μM for 16 h in 501 Mel cultures) by preventing Skp2-Cks1-mediated substrate recruitment without affecting the F-box E3 ubiquitin ligase Skp2 interaction with Cks1 or the SCF (Skp1-cullin1-F-box) c
MilliporeSigma™ Calbiochem™ D,L-Sulforaphane
An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture.
MilliporeSigma™ Calbiochem™ 1-β-D-Arabinofuranosylcytosine
Anticancer, antiviral agent that is especially effective against leukemias.
MilliporeSigma™ Calbiochem™ Necrostatin-1
Necrostatin-1, CAS 4311-88-0, is a cell-permeable, potent, and selective blocker of necroptosis (EC50 = 494 nM in FADD-deficient Jurkat cells treated with TNF-α).
MilliporeSigma™ Calbiochem™ Formyl Peptide Receptor-Like 1 Antagonist, WRW4
The Formyl Peptide Receptor-Like 1 Antagonist, WRW4 controls the biological activity of Formyl Peptide Receptor-Like 1.
MilliporeSigma™ Calbiochem™ W-5, Hydrochloride
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 230 μM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 μM).
MilliporeSigma™ Calbiochem™ NDGA
A cell-permeable antioxidant and a selective lipoxygenase (LOX) inhibitor (IC50 = 200 nM, 30 μM, and 30 μM for 5-LOX, 12-LOX, and 15-LOX, respectively) over cyclooxygenase (IC50 = 100 μM).
MilliporeSigma™ Calbiochem™ p21-Activated Kinase Inhibitor III, IPA-3
The p21-Activated Kinase Inhibitor III, IPA-3, also referenced under CAS 42521-82-4, controls the biological activity of p21-Activated Kinase. This small molecule/inhibitor is primarily used for Phosphorylation and Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Pepstatin A, Penetratin
A Pepstatin A that is ≈75% less potent against Cathespins D/E than PepA in cell-free assays.
MilliporeSigma™ Calbiochem™ Hh/Gli Antagonist, GANT58
The Hh/Gli Antagonist, GANT58, also referenced under CAS 64048-12-0, controls the biological activity of Hh/Gli. This small molecule/inhibitor is primarily used for Cell Signaling applications.