Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Autophagy Inhibitor IV, Cpd18
A cell-permeable 3-methyladenine (3-MA) derivative that acts as an autophagy inhibitor via the inhibition of class III PI3K, and without touching class I PI3K
MilliporeSigma™ Calbiochem™ (-)-Blebbistatin
The active enantiomer of (±)-Blebbistatin that accounts for the inhibitory activity towards ATPase and myosin II-dependent cellular processes.
MilliporeSigma™ Calbiochem™ Calmodulin Kinase IINtide
A potent and specific inhibitor of CaMK II (IC50 = 50 nM for both the total and Ca2+-independent CaMK II activity).
MilliporeSigma™ Calbiochem™ Cytoplasmic Dynein Inhibitor, Ciliobrevin D
Ciliobrevin D is a cell-permeable, reversible, and specific blocker of AAA+ ATPase motor cytoplasmic dynein. Disrupts spindle pole focusing and kinetochore-microtubule attachment (≈10 to 40 μM).
MilliporeSigma™ Calbiochem™ Windorphen
A cell-permeable, selective inhibitor p300 histone acetytransferase (IC50 = 4.2μM)
MilliporeSigma™ Calbiochem™ InSolution™ AMPK Inhibitor, Compound C·2HCl
The InSolution™ AMPK Inhibitor, Compound C·2HCl, also referenced under CAS 866405-64-3, controls the biological activity of AMPK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ 2,3-Butanedione 2-Monoxime
An inhibitor of skeletal and cardiac muscle contraction.
MilliporeSigma™ Calbiochem™ Leukadherin-1
A furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B.
MilliporeSigma™ Calbiochem™ Glutaminase Inhibitor, Compound 968
Glutaminase Inhibitor, Compd 968, is a cell-permeable, reversible inhibitor of mitochondrial glutaminase. Represses growth & invasive activity in glutaminase upregulated fibroblasts and tumor cells.
MilliporeSigma™ Calbiochem™ CMP-Sialic Acid, Disodium Salt InSolution™
A 25 mM (10 mg/608 μL) sterile-filtered solution of CMP-Sialic Acid, Disodium Salt in H2O.
MilliporeSigma™ Calbiochem™ InSolution™ Roscovitine
A potent and selective inhibitor of cyclin-dependent kinases (Cdks)
MilliporeSigma™ Calbiochem™ InSolution™ Phorbol-12-myristate-13-acetate
Most commonly-used phorbol ester
MilliporeSigma™ Calbiochem™ Sphingosine Kinase 1 Inhibitor, SKI-178
A cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (Ki
MilliporeSigma™ Calbiochem™ VEGF Inhibitor, V1
The VEGF Inhibitor, V1 controls the biological activity of VEGF. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Rottlerin
Rottlerin, CAS 82-08-6, is a cell-permeable, reversible inhibitor of protein kinase C with greater selectivity for PKCδ(IC50= 3-6μM) and PKCθ. Has about 10-fold lower potency against other isozymes.