Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ InSolution™ Sirtinol
A cell-permeable 2-hydroxy-1-napthaldehyde derivative that acts as a specific and a direct inhibitor of sirtuin class of histone deacetylase (HDAC) activity
MilliporeSigma™ Calbiochem™ Caspase-1 Substrate VI, Fluorogenic
Fluorogenic caspase-1 substrate.
MilliporeSigma™ Calbiochem™ Formyl Peptide Receptor-Like 1 Antagonist, WRW4
The Formyl Peptide Receptor-Like 1 Antagonist, WRW4 controls the biological activity of Formyl Peptide Receptor-Like 1.
MilliporeSigma™ Calbiochem™ Guanosine 3',5'-cyclic Monophosphorothioate, 8-(4-Chlorophenylthio)-, Rp-Isomer, Triethylammonium Salt
A potent, cell-permeable, and metabolically-stable inhibitor of protein kinase G Iα, Iβ, and type II.
MilliporeSigma™ Calbiochem™ PAR-2 Agonist I
The PAR-2 Agonist I controls the biological activity of PAR-2. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
MilliporeSigma™ Calbiochem™ Casein Kinase II Inhibitor VIII
The Casein Kinase II Inhibitor VIII controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ InSolution™ Necrostatin-1
A cell-permeable, potent, and selective blocker of necroptosis (EC50 = 494nM in FADD-deficient Jurkat cells treated with TNF-α), a nonapoptotic necrotic cell death pathway mediated by death-domain receptors (DRs) that offers neuroprotection in a murine model of ischemic brain inj
MilliporeSigma™ Calbiochem™ IP6K Inhibitor
The IP6K Inhibitor, also referenced under CAS 519178-28-0, controls the biological activity of IP6K.
MilliporeSigma™ Calbiochem™ AG 1024
A cell-permeable, reversible, substrate competitive, and specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity.
MilliporeSigma™ Calbiochem™ Histone Lysine Demethylase Inhibitor VIII, GSK-J4
Histone Lysine Demethylase Inhibitor VIII, GSK-J4, CAS 1373423-53-0, is converted to GSK-J1 intracellularly for effective JMJD3 and UTX inhibition (∽ 25 to 50μM in HeLa cultures).
MilliporeSigma™ Calbiochem™ AG 538
A potent, cell-premeable, reversible, and competitive inhibitor of IGF-1 receptor kinase (IC50 = 400 nM).
MilliporeSigma™ Calbiochem™ Pin1 Inhibitor, DTM
A cell permeable competitive inhibitor of Pin1 (EC50 = 4.1 μM, Ki = 50 nM).
MilliporeSigma™ Calbiochem™ InSolution™ H-89, Dihydrochloride
InSolution™ H-89, Dihydrochloride, CAS 127243-85-0, is a 10mm solution of H-89, 2HCl in DMSO. A cell-permeable, potent, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 48nM).
MilliporeSigma™ Calbiochem™ PKCε Peptide Substrate
Pseudosubstrate region of the ε-isotype of protein kinase C (PKCε
MilliporeSigma™ Calbiochem™ ApoE4 Modulator, PH002
A phthalazinone derived compound that directly binds to the 22-kDa amino-terminal region of apolipoprotein E4 (ApoE4) and blocks its intramolecular domain interactions in neuronal cells thereby reversing the detrimental effects of ApoE4.